CK1d Protein, Human (His)
The CK1d protein is an important serine/threonine protein kinase that complexly controls cellular processes such as Wnt signaling, DNA repair, and circadian rhythms. Its versatility is evident in phosphorylating a variety of proteins, including connexin-43/GJA1, MAP1A, p53/TP53, and YAP1. CK1d, Human (His) is the recombinant human-derived CK1d protein, expressed by E. coli, with labeled tag.
- Species: Human
- Source: E. coli
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
The CK1d protein is an important serine/threonine protein kinase that complexly controls cellular processes such as Wnt signaling, DNA repair, and circadian rhythms. Its versatility is evident in phosphorylating a variety of proteins, including connexin-43/GJA1, MAP1A, p53/TP53, and YAP1. CK1d, Human (His) is the recombinant human-derived CK1d protein, expressed by E. coli, with labeled tag.
CK1d Protein, an essential serine/threonine-protein kinase, intricately regulates cellular growth and survival processes encompassing Wnt signaling, DNA repair, and circadian rhythms. Demonstrating versatility, CK1d phosphorylates a diverse array of proteins, including connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1, and PER2. It plays a central role in the circadian clock, determining the period length through the regulation of PER1 and PER2 phosphorylation. Additionally, CK1d influences the WNT3A signaling pathway, neuronal outgrowth, ubiquitination of YAP1, DNA-binding activity of DNMT1, and numerous other cellular processes. This multifaceted kinase emerges as a key player in coordinating diverse cellular functions and signaling pathways.
Technical Parameters
-
Species Human
-
Source E. coli
-
Tag N-10*His
-
Accession
P48730 (M1-R415)
-
Gene ID1453
-
Molecular Construction
-
N-term
-
10*His
-
CK1d (M1-R415)
Accession # P48730 -
C-term
-
-
Protein Length
Full Length
-
Synonyms
CSNK1D; CKI-Delta; Casein Kinase 1 Delta; Non-Specific Serine/Threonine Protein Kinase; HCKID; Casein Kinase 1, Delta; CKIdelta; Casein Kinase I; CKID; FASPS2; Casein Kinase I Isoform Delta; ASPS; Tau-Protein Kinase CSNK1D; CKId
-
AA Sequence
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
-
Predicted Molecular Mass
53.4 kDa
-
Molecular Weight
Approximately 54 kDa, based on SDS-PAGE under reducing conditions.
-
Structure/Form
Monomer
-
Purity
≥ 90%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
