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MMP Substrate

" in MedChemExpress (MCE) Product Catalog:

58

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7

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23

Biochemical Assay Reagents

29

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N1420
    Rhamnose
    1 Publications Verification

    L-Rhamnose

    Environmental Pollutants Endogenous Metabolite PKA MMP Interleukin Related Infection Metabolic Disease Cancer
    Rhamnose (L-Rhamnose ) is an orally active deoxysugar. Rhamnose can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas .
    Rhamnose
  • HY-P4931
    Mca-KPLGL-Dap(Dnp)-AR-NH2
    1 Publications Verification

    MMP Cancer
    Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1 . (Ex/Em=325 nm/400 nm)
    Mca-KPLGL-Dap(Dnp)-AR-NH2
  • HY-131498

    Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2

    Fluorescent Dye MMP Cancer
    MOCAc-PLGL (Dpa) AR (Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) is a synthetic fluorescent substrate mainly used for in vitro enzymatic activity assays of MMP-7 (detection at 393 nm after excitation at 328 nm). MOCAc-PLGL (Dpa) AR is specifically cleaved and hydrolyzed by MMP-7 at the Gly-Leu peptide bond, allowing enzymatic activity to be monitored via fluorometry or HPLC (DMSO is usually added to ensure sufficient dissolution when determining kinetic parameters). MOCAc-PLGL (Dpa) AR is used to accurately evaluate the catalytic activity and pH dependence of recombinant mature human MMP-7 in vitro. MOCAc-PLGL (Dpa) AR is suitable for research on the mechanisms of tumor metastasis and invasion, particularly in fields such as prostate cancer, colon cancer, lung cancer and breast cancer .\n
    MOCAc-PLGL(Dpa)AR
  • HY-N1420A
    Rhamnose monohydrate
    1 Publications Verification

    L-Rhamnose monohydrate

    Endogenous Metabolite MMP Interleukin Related PKA Infection Metabolic Disease Cancer
    Rhamnose monohydrate (L-Rhamnose monohydrate) is an orally active deoxysugar. Rhamnose monohydrate can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose monohydrate can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose monohydrate shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas .
    Rhamnose monohydrate
  • HY-P2179

    Fluorescent Dye MMP Others
    MMP-1/MMP-9 Substrate, Fluorogenic is a fluorogenic substrate for MMP-1 and MMP-9 .Ex/Em = 340/440 nm
    MMP-1/MMP-9 Substrate, Fluorogenic
  • HY-N0419
    Quercimeritrin
    2 Publications Verification

    Quercetin-7-O-β-D-glucopyranoside

    Glycosidase c-Kit MMP VEGFR Aurora Kinase Metabolic Disease Cancer
    Quercimeritrin (Quercetin-7-O-β-D-glucopyranoside) is an orally active α-glucosidase inhibitor (with an IC50 of 79.88 μM against the Saccharomyces cerevisiae enzyme) and a P-gp substrate, with anti-angiogenic and antioxidant activities. Quercimeritrin does not cross the blood-brain barrier and does not inhibit cytochrome P450 enzymes. Quercimeritrin precisely binds to and inhibits the active sites of c-Kit, MMP-2, Aurora-A kinases and α-glucosidase, thereby disrupting target functions. Quercimeritrin effectively regulates postprandial blood glucose and also exhibits significant anti-angiogenic activity, which inhibits endothelial cell proliferation and microvascular growth. Quercimeritrin can be used in the research of diabetes and breast cancer .
    Quercimeritrin
  • HY-P2185A

    MMP Others
    NFF-3 TFA, the peptide, is a selective MMP substrate. NFF-3 TFA selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 TFA is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 TFA with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .
    NFF-3 TFA
  • HY-P10143

    Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt

    MMP Others
    MMP-2/MMP-9 Substrate (Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt) is a synthetic chromogenic polypeptide substrate whose core structure mimics the cleavage sites of MMP-2 and MMP-9 (gelatinase A and B) in collagen. After being hydrolyzed by collagenase, MMP-2/MMP-9 Substrate reacts with 4,4'-dithiodipyridine or Ellman's Reagent via its thiol fragment to produce a product with ultraviolet absorption properties .
    MMP-2/MMP-9 Substrate
  • HY-P10043

    MMP Others
    MMP-1 Substrate is a matrix metalloproteinase-1 (MMP-1) selective substrate that can be used for the fluorometric determination of MMP-1 enzymatic activity .
    MMP-1 Substrate
  • HY-P3484

    MMP Cancer
    Dnp-PLGLWA-DArg-NH2 TFA is a fluorogenic substrate for MMP-1 and MMP-9. Dnp-PLGLWA-DArg-NH2 TFA can be used to quantify the activity of MMPs (Ex=280 nm, Em=360 nm) .
    Dnp-PLGLWA-DArg-NH2 TFA
  • HY-NP109

    Mouse Type I collagen, immunization grade

    MMP Inflammation/Immunology
    Highly purified type I collagen, from mouse skin (Mouse Type I collagen, immunization grade) is an immune grade collagen derived from mouse skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified type I collagen, from mouse skin
  • HY-NP113

    Chick Type II collagen, immunization grade

    MMP Inflammation/Immunology
    Highly purified Type II collagen, from chick sternal cartilage (Chick Type II collagen, immunization grade) is an immune grade collagen derived from chick sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified Type II collagen, from chick sternal cartilage
  • HY-N1420AR

    L-Rhamnose monohydrate (Standard)

    Reference Standards Endogenous Metabolite MMP Interleukin Related PKA Infection Metabolic Disease Cancer
    Rhamnose monohydrate (Standard) is the analytical standard of Rhamnose monohydrate (HY-N1420A). Rhamnose monohydrate (L-Rhamnose monohydrate) is an orally active deoxysugar. Rhamnose monohydrate can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose monohydrate can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose monohydrate shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas .
    Rhamnose monohydrate (Standard)
  • HY-P5380

    Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2

    MMP Fluorescent Dye Others
    TNO211 (Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2) is a fluorogenic substrate, containing the MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencer combination. TNO211 can specifically detect MMP activity (Ex/Em = 340/485 nm) .
    TNO211
  • HY-P2414

    MMP Inflammation/Immunology
    MMP-13 Substrate is a substrate of MMP-13. MMP-13 Substrate can be used for the research of osteoarthritis (OA) .
    MMP-13 Substrate
  • HY-P3120

    MMP Fluorescent Dye Others
    Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2, upon cleavage by MMP-14, releases 7-methoxycoumarin-4-acetyl (Mca) (Ex/Em = 328/420 nm).
    Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2
  • HY-NP126

    Porcine Type XI collagen, immunization grade

    MMP Inflammation/Immunology
    Highly purified Type XI collagen, from porcine articular cartilage (Porcine Type XI collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified Type XI collagen, from porcine articular cartilage
  • HY-P3699

    MMP Fluorescent Dye Others
    TNO003 is a selective fluorogenic substrate for stromelysin-1 (MMP-3). TNO003 has higher selectivity for MMP-3 than MMP-1, MMP-2, MMP-7, MMP-8, MMP-9 and MMP-13. TNO003 can be used for the determination of stromelysin activity (Ex/Em = 360/490 nm) .
    TNO003
  • HY-P3477

    Fluorescent Dye Others
    Mca-PLA-Nva-Dap(Dnp)-AR-NH2 is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) .
    Mca-PLA-Nva-Dap(Dnp)-AR-NH2
  • HY-P2185

    MMP Others
    NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .
    NFF-3
  • HY-P3123A

    Fluorescent Dye Others
    Dnp-RPLALWRS TFA is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS TFA at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS TFA provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .
    Dnp-RPLALWRS TFA
  • HY-P4931A

    Fluorescent Dye Others
    Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA is a fluorogenic substrate for matrix metalloproteinases (MMPs). 7-methoxycoumarin-4 acetyl (Mac) is released and its fluorescence can be used to quantify MMP activity. Mac displays Ex/Em of 328/420 nm .
    Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA
  • HY-NP103

    Bovine Type III collagen, immunization grade

    MMP Inflammation/Immunology
    Highly purified Type III collagen, from bovine skin (Bovine Type III collagen, immunization grade) is an immune grade collagen derived from bovine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified Type III collagen, from bovine skin
  • HY-P5380A

    Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2 TFA

    MMP Fluorescent Dye Cancer
    TNO211 (Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2) TFA is a fluorogenic substrate, containing the MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencer combination. TNO211 TFA can specifically detect MMP activity (Ex/Em = 340/485 nm) .
    TNO211 TFA
  • HY-P2682

    MMP Metabolic Disease
    MMP-8/MMP-26 Fluorogenic substrate (DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg) is a matrix metalloproteinase-8 (MMP-8) fluorogenic substrate. MMP-8/MMP-26 Fluorogenic substrate can be used for the research of atherosclerosis, pulmonary fibrosis, and sepsis .
    MMP-8/MMP-26 Fluorogenic substrate
  • HY-P2414A

    MMP Inflammation/Immunology
    MMP-13 Substrate TFA is a substrate of MMP-13. MMP-13 Substrate TFA can be used for the research of osteoarthritis (OA) .
    MMP-13 Substrate TFA
  • HY-P3098

    MMP Others
    Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .
    Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2
  • HY-NP124

    Porcine Type III collagen, immunization grade

    MMP Inflammation/Immunology
    Highly purified Type III collagen, from porcine skin (Porcine Type III collagen, immunization grade) is an immune grade collagen derived from porcine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified Type III collagen, from porcine skin
  • HY-NP107

    Rat Type I collagen, immunization grade

    MMP Inflammation/Immunology
    Highly purified Type I collagen, from rat skin (Rat Type I collagen, immunization grade) is an immune grade collagen derived from rat skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified Type I collagen, from rat skin
  • HY-NP111

    Mouse Type V collagen, immunization grade

    MMP Inflammation/Immunology
    Highly purified Type V collagen, from mouse intestine (Mouse Type II collagen, immunization grade) is an immune grade collagen derived from mouse intestine, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified Type V collagen, from mouse intestine
  • HY-NP106

    Bovine Type XI collagen, immunization grade

    MMP Inflammation/Immunology
    Highly purified Type XI collagen, from bovine articular cartilage (Bovine Type XI collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified Type XI collagen, from bovine articular cartilage
  • HY-P4905

    MMP Cancer
    Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is highly selective substrate for matrix metalloproteases 12 (MMP12) substrate with a kcat/Km value of 1.85*10 5 M -1s -1, and poor substrate of other MMPs with the exception of MMP13 (kcat/Km = 0.53*10 5 M -1s -1) and MMP9 (0.33*10 5 M -1s -1) .
    Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2
  • HY-P4574

    MMP Others
    VPLSLYSG is an octapeptide that can be degraded by matrix metalloproteinase-9 (MMP-9), MMP-1 and MMP-2. VPLSLYSG has potential applications in MMP substrates .
    VPLSLYSG
  • HY-P3699A

    MMP Fluorescent Dye Others
    TNO003 TFA is a selective fluorogenic substrate for stromelysin-1 (MMP-3). TNO003 TFA has higher selectivity for MMP-3 than MMP-1, MMP-2, MMP-7, MMP-8, MMP-9 and MMP-13. TNO003 TFA can be used for the determination of stromelysin activity (Ex/Em = 360/490 nm) .
    TNO003 TFA
  • HY-W277900

    MMP Inflammation/Immunology Cancer
    2-Methoxy-2,4-diphenylfuran-3-one is a fluorescent compound which can be used to label gelatin as a substrate for detection of the gelatin degrading MMP-2 and MMP-9 by zymography .
    2-Methoxy-2,4-diphenylfuran-3-one
  • HY-P2089

    MMP Others
    Dnp-PYAYWMR is a peptide substrate that selectively targets MMP3. Dnp-PYAYWMR is cleaved by MMP3 to produce Dnp-PYA (nonfluorescent) and YWMR (fluorophore detectable at 360 nm). After incubation of MMP3 with Dnp-PYAYWMR for 2 h, MMP3 fluorescence intensity was measured. Ex/Em=328/350 nm .
    Dnp-PYAYWMR
  • HY-P3123

    Fluorescent Dye Others
    Dnp-RPLALWRS is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .
    Dnp-RPLALWRS
  • HY-P4937

    MMP Cancer
    NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys-(DMC)-NH2 is an substrate for hydrolysis of the matrix metalloproteinase stromelysin (MMP-3) and can be easily detected at Abs/Em=350/465 nm .
    NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys-(DMC)-NH2
  • HY-P2608

    Fluorescent Dye Others
    DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH is the substrate for matrix metalloproteinase MMP-1, with a Km of 26.61 μM. DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH is utilized as fluorescence probe for detecting protein activity .
    DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH
  • HY-P2716

    MMP Others
    Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 is a biological active peptide. (MMP substrate)
    Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2
  • HY-P10139

    MMP Others
    Dnp-PLGLWAr-NH2 is a synthetic collagenase/gelatinase substrate. Dnp-PLGLWAR-NH2 can be used to quantify total MMP activity in APMA-activated conditioned medium samples .
    Dnp-PLGLWAr-NH2
  • HY-NP127

    Canine Type I collagen, immunization grade

    MMP Inflammation/Immunology
    Highly purified Type I collagen, from canine skin (Canine Type I collagen, immunization grade) is an immune grade collagen derived from canine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified Type I collagen, from canine skin
  • HY-NP122

    Porcine Type I collagen, immunization grade

    MMP Inflammation/Immunology
    Highly purified Type I collagen, from porcine skin (Porcine Type I collagen, immunization grade) is an immune grade collagen derived from porcine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified Type I collagen, from porcine skin
  • HY-NP128

    Rabbit Type I collagen, immunization grade

    MMP Inflammation/Immunology
    Highly purified Type I collagen, from rabbit skin (Canine Type I collagen, immunization grade) is an immune grade collagen derived from rabbit skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified Type I collagen, from rabbit skin
  • HY-NP108

    Rat Type II collagen, immunization grade

    MMP Inflammation/Immunology
    Highly purified type II collagen, from rat sternal cartilage (Rat Type II collagen, immunization grade) is an immune grade collagen derived from rat sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified type II collagen, from rat sternal cartilage
  • HY-NP105

    Bovine Type IX collagen, immunization grade

    MMP Inflammation/Immunology
    Highly purified Type IX collagen, from bovine articular cartilage (Bovine Type IX collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified Type IX collagen, from bovine articular cartilage
  • HY-NP130

    Goat Type II collagen, immunization grade

    MMP Inflammation/Immunology
    Highly purified Type II collagen, from goat articular cartilage (Goat Type II collagen, immunization grade) is an immune grade collagen derived from goat articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified Type II collagen, from goat articular cartilage
  • HY-NP123

    Porcine Type II collagen, immunization grade

    MMP Inflammation/Immunology
    Highly purified Type II collagen, from porcine articular cartilage (Porcine Type II collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified Type II collagen, from porcine articular cartilage
  • HY-NP125

    Porcine Type IX collagen, immunization grade

    MMP Inflammation/Immunology
    Highly purified Type IX collagen, from porcine articular cartilage (Porcine Type IX collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .
    Highly purified Type IX collagen, from porcine articular cartilage
  • HY-P11641

    MMP Inflammation/Immunology
    GCRRGPLGLSLGKRRCG is an MMP13-specific substrate peptide cleaved by MMP13. GCRRGPLGLSLGKRRCG contributes to an MMP13-responsive hydrogel microsphere system that achieves intelligent and controllable drug release in osteoarthritis (OA), decelerates disease progression, and promotes articular cartilage repair. GCRRGPLGLSLGKRRCG can be used for the research of osteoarthritis .
    GCRRGPLGLSLGKRRCG

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