Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA, upon cleavage by MMP-14, releases 7-methoxycoumarin-4-acetyl (Mca) (Ex/Em = 328/420 nm).
For research use only. We do not sell to patients.
- CAS No.: 2237216-67-8
- Formula: C68H83F3N16O19S
- Molecular Weight:1517.54
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Biological Activity
Description
IC50 & Target
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MMP-14 |
Chemical Information
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CAS No. 2237216-67-8
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Appearance Solid
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Molecular Weight 1517.54
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Formula C68H83F3N16O19S
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Color White to off-white
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SMILES
COC1=CC=C2C(OC(C=C2CC(N3[C@@H](CCC3)C(N[C@H](C(N[C@@H](C)C(N[C@@H](CSCC4=CC=C(C=C4)OC)C(N[C@@H](CC5=CNC6=C5C=CC=C6)C(N[C@@H](C)C(N[C@H](C(N[C@@H](CNC7=C(C=C(C=C7)[N+]([O-])=O)[N+]([O-])=O)C(N)=O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=C1.OC(C(F)(F)F)=O
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Sequence
{Mca}-Pro-Leu-Ala-{Cys(Mob)}-Trp-Ala-Arg-{Dap(Dnp)}-NH2
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Sequence Shortening
{Mca}-PLA-{Cys(Mob)}-WAR-{Dap(Dnp)}-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (259 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)