2. Metabolic Enzyme/Protease Others
  3. MMP Fluorescent Dye
  4. TNO211

TNO211  (Synonyms: Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2)

Cat. No.: HY-P5380 Purity: 99.41%
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TNO211 (Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2) is a fluorogenic substrate, containing the MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencer combination. TNO211 can specifically detect MMP activity (Ex/Em = 340/485 nm).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

TNO211

TNO211 Chemical Structure

CAS No. : 193475-71-7

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TNO211 Related Antibodies

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Description

TNO211 (Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2) is a fluorogenic substrate, containing the MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencer combination. TNO211 can specifically detect MMP activity (Ex/Em = 340/485 nm)[1].

Molecular Weight

1325.54

Formula

C63H88N16O14S
CAS No.
Appearance

Solid

Color

Yellow to orange

Sequence

{DABCYL-GABA}-Pro-Gln-Gly-Leu-Glu-{EDANS}-Ala-Lys-NH2
Sequence Shortening

{DABCYL-GABA}-PQGL-{Glu(EDANS)}-AK-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (75.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7544 mL 3.7720 mL 7.5441 mL
5 mM 0.1509 mL 0.7544 mL 1.5088 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7544 mL 3.7720 mL 7.5441 mL 18.8602 mL
5 mM 0.1509 mL 0.7544 mL 1.5088 mL 3.7720 mL
10 mM 0.0754 mL 0.3772 mL 0.7544 mL 1.8860 mL
15 mM 0.0503 mL 0.2515 mL 0.5029 mL 1.2573 mL
20 mM 0.0377 mL 0.1886 mL 0.3772 mL 0.9430 mL
25 mM 0.0302 mL 0.1509 mL 0.3018 mL 0.7544 mL
30 mM 0.0251 mL 0.1257 mL 0.2515 mL 0.6287 mL
40 mM 0.0189 mL 0.0943 mL 0.1886 mL 0.4715 mL
50 mM 0.0151 mL 0.0754 mL 0.1509 mL 0.3772 mL
60 mM 0.0126 mL 0.0629 mL 0.1257 mL 0.3143 mL
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TNO211 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNO211193475-71-7Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2TNO 211TNO-211MMPFluorescent DyeMatrix metalloproteinasesfluorogenic substrate MMPGly-LeuInhibitorinhibitorinhibit

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