Cat. No.: HY-N1420

Rhamnose

(Synonyms: L-Rhamnose)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Rhamnose (L-Rhamnose ) is an orally active deoxysugar. Rhamnose can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 3615-41-6
Formula: C₆H₁₂O₅
Molecular Weight:164.16

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Rhamnose Chemical Structure

CAS No.: 3615-41-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Microbial Metabolite

All MMP Isoforms :

All PKA Isoforms :

All Endogenous Metabolite Isoforms :

All Interleukin Related Isoforms :

In Vitro

Rhamnose (50 mM, 30 h) can regulate the expression of P_rha target genes in Listeria monocytogenes^[1].
Rhamnose (1 mM) can reduce the levels of pro-inflammatory interleukins and matrix metalloproteinases (MMPs) in a human dermal fibroblast (NHDF) skin aging model stimulated by advanced glycation end products (AGEs), thus possessing anti-aging potential^[2].
Rhamnose (0-300 μM, 1 h) promotes phosphorylation of PKA substrate and HSL in SVF-derived adipocytes, stimulates PKA signaling and induces thermogenesis^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1].

Cell Line:

L. monocytogenes 10403S
Concentration:

50 mM
Incubation Time:

30 h
Result:

Promoted the growth of L. monocytogenes.

In Vivo

Rhamnose (0.25-1 mg/mL (dissolve in water; 9 weeks; p.o.) or 300 mg/kg (7 days; i.p.)) has anti-obesity effects in obese mice through stimulation of adipose dopamine receptors and thermogenesis^[3].
Rhamnose (5-15 mg/kg; i.p.) competitively inhibits the toxic effects of BEC on murine sarcoma 180 (S180) and reduces survival in sarcoma-bearing mice^[4].
Rhamnose (1-5 g/kg; once daily; 14 days; i.p.) has antitumor activity in mice with Ehrlich’s solid tumor^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Diet induced obese mice obtained by administering high-fat diet (HFD) to 6-week-old male C57BL/6J mice for a total of 9-10 weeks^[3].
Dosage:

0.25, 0.5, 1 mg/mL (dissolve in water) or 300 mg/kg
Administration:

Oral gavage (p.o.), 9 weeks; Intraperitoneal injection (i.p.), 7 days
Result:

Reduced the total fat content of mice, improved glucose sensitivity, and promoted the expression of thermogenic genes.

Animal Model:

Herston White mice injected intraperitoneally with S180 tumor cells, 30 g, aged 8-10 weeks^[4].
Dosage:

5, 10, 15 mg/kg
Administration:

Intraperitoneal injection (i.p.); the first dose was given 0.5 h after administration of the S180 tumour cells and the remaining three doses were given at daily intervals
Result:

Reduced the survival rate of mice in a dose-dependent manner in the presence of BEC.

Animal Model:

NMRI female mouse model of subcutaneous inoculation of Ehrlich's solid tumor (SET)^[5].
Dosage:

1, 3, 5 g/kg
Administration:

Intraperitoneal injection (i.p.); once daily; 14 days
Result:

Inhibited tumor growth and prolonged the survival time of mice.

Chemical Information

CAS No. 3615-41-6
Appearance Solid
Molecular Weight 164.16
Formula C₆H₁₂O₅
Color White to off-white
SMILES

O=C[C@@H]([C@@H]([C@H]([C@H](C)O)O)O)O
Synonyms

L-Rhamnose
Structure Classification
- Saccharides
- Monosaccharides
Initial Source
- Plants
- other families
- Microorganisms
- Endogenous metabolite
Widespread
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Ultrason Sonochem

Ultrasonic complexation with Lycium barbarum polysaccharide significantly enhances the aqueous solubility and bioavailability of curcumin. [Abstract]

2025 Dec:123:107673. PMID: 41223460

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (609.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (609.16 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.0916 mL

30.4581 mL

60.9162 mL

5 mM

1.2183 mL

6.0916 mL

12.1832 mL

10 mM

0.6092 mL

3.0458 mL

6.0916 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(start) Volume _(start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (15.23 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (15.23 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (15.23 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 50 mg/mL (304.58 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fieseler L, et al. Rhamnose-inducible gene expression in Listeria monocytogenes. PLoS One. 2012;7(8):e43444. [Content Brief]

[2]. Novotná R, et al. Hesperidin, Hesperetin, Rutinose, and Rhamnose Act as Skin Anti-Aging Agents. Molecules. 2023 Feb 11;28(4):1728. [Content Brief]

[3]. Lv S, et al. Rhamnose Displays an Anti-Obesity Effect Through Stimulation of Adipose Dopamine Receptors and Thermogenesis. Diabetes. 2023 Mar 1;72(3):326-335. [Content Brief]

[4]. Cham BE, et al. Selective cytotoxicity for cancer cells and inhibition of cytotoxicity by rhamnose in mice with sarcoma 180. Cancer Lett. 1990 Dec 17;55(3):221-5. [Content Brief]

[5]. Tomsik P, et al. L-rhamnose and L-fucose suppress cancer growth in mice[J]. Central European Journal of Biology, 2011, 6: 1-9.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	6.0916 mL	30.4581 mL	60.9162 mL	152.2904 mL
	5 mM	1.2183 mL	6.0916 mL	12.1832 mL	30.4581 mL
	10 mM	0.6092 mL	3.0458 mL	6.0916 mL	15.2290 mL
	15 mM	0.4061 mL	2.0305 mL	4.0611 mL	10.1527 mL
	20 mM	0.3046 mL	1.5229 mL	3.0458 mL	7.6145 mL
	25 mM	0.2437 mL	1.2183 mL	2.4366 mL	6.0916 mL
	30 mM	0.2031 mL	1.0153 mL	2.0305 mL	5.0763 mL
	40 mM	0.1523 mL	0.7615 mL	1.5229 mL	3.8073 mL
	50 mM	0.1218 mL	0.6092 mL	1.2183 mL	3.0458 mL
	60 mM	0.1015 mL	0.5076 mL	1.0153 mL	2.5382 mL
	80 mM	0.0761 mL	0.3807 mL	0.7615 mL	1.9036 mL
	100 mM	0.0609 mL	0.3046 mL	0.6092 mL	1.5229 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Rhamnose

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Publications Citing Use of MedChemExpress (MCE) Rhamnose

All MMP Isoforms

All PKA Isoforms

All Endogenous Metabolite Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Rhamnose Related Classifications

HY-N1420 Related Classifications