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O-GlcNAc

" in MedChemExpress (MCE) Product Catalog:

By Targets:	OGA (4) OGT (13) Acyltransferase (4) Akt (1) Apoptosis (1) Autophagy (1) Biochemical Assay Reagents (3) Drug Intermediate (1) Endogenous Metabolite (2) Fluorescent Dye (1) Glycosidase (2) Glycosyltransferase (1) GSK-3 (1) Isotope-Labeled Compounds (1) MDM-2/p53 (1) mTOR (1) P2Y Receptor (1) PARP (1) Potassium Channel (1) Reactive Oxygen Species (ROS) (1) Ser/Thr Protease (1) Small Interfering RNA (siRNA) (1) Tau Protein (1)
By Research Areas:	Cancer (4) Endocrinology (1) Infection (1) Inflammation/Immunology (2) Metabolic Disease (8) Neurological Disease (3)
Click Chemistry:	Azide (1) Alkynes (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: OGA OGT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119738

OSMI-1 40+ Cited Publications	OGT Acyltransferase	Metabolic Disease
OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC₅₀ value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .

HY-12588

Thiamet G Maximum Cited Publications 48 Publications Verification	OGA Autophagy	Cancer
Thiamet G is a potent and selective inhibitor of O-GlcNAcase (OGA), which acts to remove O-GlcNAc from modified proteins, with K_i of 20 nM for human OGA.

HY-114361

OSMI-4 25+ Cited Publications	OGT Acyltransferase	Metabolic Disease
OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC₅₀ of 3 μM in cells.

HY-112174

*UDP-GlcNAc* disodium** 5+ Cited Publications UDP-α-D-N-Acetylglucosamine disodium	OGT	Metabolic Disease
UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (OGT).

HY-N3677

Dammarenediol II	OGT Akt mTOR GSK-3 Reactive Oxygen Species (ROS) Apoptosis PARP MDM-2/p53	Inflammation/Immunology Cancer
Dammarenediol II is a ginsenoside precursor . Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy .

HY-148113

PG 34	OGT	Others
PG 34 is a weak O-GlcNAc transferase (OGT) inhibitor (IC₅₀=68 μM), and a close structural analog of OSMI-1 (HY-119738) .

HY-W423080

TAMRA alkyne,5-isomer	Biochemical Assay Reagents Fluorescent Dye	Others
TAMRA alkyne, 5-isomer (Compound 3) is an alkyne derivative of TAMRA and can be used for the enrichment, in-gel fluorescence detection, and identification of O-GlcNAc-modified proteins. TAMRA alkyne, 5-isomer contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Azide groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-139793

UDP-glucosamine disodium	OGT Endogenous Metabolite	Metabolic Disease
UDP-glucosamine (UDP-GlcNAc) disodium is a substrate for O-GlcNAc transferase, which catalyzes the attachment of O-GlcNAc to proteins. O-GlcNAcase catalyzes the removal of O-GlcNAc from proteins. UDP-glucosamine (UDP-GlcNAc) disodium is the end product of the hexosamine biosynthesis pathway, which is regulated primarily by glucose-6-phosphate-Glutamine:fructose-6-phosphate amidotransferase (GFAT) .

HY-W039921

2-[(Azidoacety)amino]-2-deoxy-D-galactose N-Azidoacetylgalactosamine; GalNAz	Biochemical Assay Reagents	Others
2-[(Azidoacety)amino]-2-deoxy-D-galactose targets O-GlcNAc-modified proteins. By detecting and targeting O-GlcNAc-modified proteins, 2-[(Azidoacety)amino]-2-deoxy-D-galactose can serve as a chemical tag for intracellular sugar chain metabolism .

HY-148596

UDP-GlcNAc UDP-N-Acetyl-D-glucosamine; Uridine diphospho-N-acetylglucosamine; UDP-N-acetylglucosamine	Endogenous Metabolite P2Y Receptor Drug Intermediate Glycosyltransferase	Infection
UDP-GlcNAc (UDP-N-Acetyl-D-glucosamine) is an important component and precursor of bacterial peptidoglycan. UDP-GlcNAc is a nucleotide sugar used by Glycosyltransferases to synthesize glycoproteins, glycosaminoglycans, glycolipids, and glycoRNA. UDP-GlcNAc also serves as the donor substrate for forming O-GlcNAc, a dynamic intracellular protein modification involved in diverse signaling and disease processes. UDP-GlcNAc is the sugar nucleotide donor for the synthesis of O-GlcNAc modified proteins. UDP-GlcNAc also acts as a full agonist of the P2Y₁₄ receptor and inhibits the formation of cAMP. UDP-GlcNAc can be used in studies related to bacterial infections .

HY-W039939

2-Azido-2-deoxy-D-glucose, 98% 2-ADG, 98%	Biochemical Assay Reagents OGT	Cancer
2-Azido-2-deoxy-D-glucose, 98% (2-ADG, 98%) is a substrate of O-GlcNAc transferase (OGT). 2-Azido-2-deoxy-D-glucose, 98% can be transferred from UDP-GlcAz to proteins in vitro via OGT mediation. When delivered as AcGlcAz, 2-Azido-2-deoxy-D-glucose, 98% enables the labeling and investigation of O-GlcNAc-modified nuclear and cytoplasmic proteins in cells. 2-Azido-2-deoxy-D-glucose, 98% undergoes strain-promoted [3+2] azide-alkyne cycloaddition (SPAAC) with technetium- ^99m-labeled dibenzocyclooctyne derivatives in vivo. 2-Azido-2-deoxy-D-glucose, 98% can be used in sarcoma-related research .

HY-149552

Ac4-5SGlcNAc	OGT	Cancer
Ac4-5SGlcNAc is an O-GlcNAc transferase (OGT) inhibitor. Ac4-5SGlcNAc converts intracellularly to UDP-5SGlcNAc, which competes with native UDP-GlcNAc (HY-148596) to block OGT catalytic activity, reduces cellular UDP-GlcNAc pools, and limits global protein O-GlcNAcylation. Ac4-5SGlcNAc reduces OGA levels via feedback, alters lectin signal intensities and glycan-related band masses. Ac4-5SGlcNAc can be used for the research of breast cancer .

HY-125278

OGT-IN-4	OGT	Others
OGT-IN-4 (compound 4a) is an O-GlcNAc transferase (OGT) inhibitor with a K_d of 8 nM. OGT-IN-4 can be utilized in OGT related research .

HY-101548

OGT-IN-1	OGT	Metabolic Disease
OGT-IN-1 (Compound 5) is a potent OGT inhibitor. OGT-IN-1 inhibits sOGT and ncOGT with IC₅₀s of 27 and 10 μM, respectively .

HY-112174S

*UDP-GlcNAc-13C disodium* UDP-α-D-N-Acetylglucosamine-13C disodium	Isotope-Labeled Compounds	Metabolic Disease
UDP-GlcNAc- ¹³C (disodium) is the ¹³C labeled UDP-GlcNAc Disodium Salt. UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (O .

HY-119738A

(Rac)-OSMI-1	OGT Acyltransferase	Metabolic Disease
(Rac)-OSMI-1 is the racemate of OSMI-1. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC₅₀ value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .

HY-RS09765

OGT Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
OGT Human Pre-designed siRNA Set A contains three designed siRNAs for OGT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

OGT Human Pre-designed siRNA Set A OGT Human Pre-designed siRNA Set A

HY-E70880

Endoglycosidase CC (N180H mutant) EndoCC N180H	Glycosidase	Others
Endoglycosidase CC (N180H mutant) (EndoCC N180H) is a mutant endoglycosidase, which efficiently and specifically recognizes core fucose and O-GlcNAc .

HY-E70881

Endoglycosidase F3 (D165A mutant) EndoF3 D165A	Glycosidase	Others
Endoglycosidase F3 (D165A mutant) (EndoF3 D165A) is a mutant endoglycosidase, which efficiently and specifically recognizes core fucose and O-GlcNAc .

HY-135785

OSMI-3	OGT Acyltransferase	Metabolic Disease
OSMI-3 (Compound 2b) is a potent, long-lasting, and cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-3 increases detained intron splicing in cells .

HY-148240

JNJ-65355394	OGA	Neurological Disease
JNJ-65355394 (Compound 28), a chemical probe, is an O-GlcNAc hydrolase (OGA) inhibitor .

HY-W477597

BZX2	OGT	Others
BZX2 is an irreversible covalent inhibitor of O-GlcNAc transferase (OGT) with an IC₅₀ of <10 µM. BZX2 is cell-permeable but exhibits multiple off-target effects .

HY-P10572

HG1 Toxin	Ser/Thr Protease Potassium Channel	Inflammation/Immunology Endocrinology
HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, which has the activity of inhibiting potassium channel Kv1.3. HG1 Toxin also has the activity of inhibiting trypsin (K_i=107 nM) and can be used in the study of autoimmune diseases .

HY-185146

O-GlcNAcase-IN-5	OGA Tau Protein	Neurological Disease
O-GlcNAcase-IN-5 (Compound 1) is a selective O-GlcNAcase inhibitor. O-GlcNAcase-IN-5 can prevent the enzyme from removing the O-GlcNAc modification on tau protein, thus avoiding excessive phosphorylation of tau protein. O-GlcNAcase-IN-5 can be used for the research of Alzheimer's disease .

HY-183557

O-GlcNAcase-IN-6	OGA	Neurological Disease
O-GlcNAcase-IN-6 is an orally active, blood-brain barrier-permeable O-GlcNAcase (OGA) inhibitor with an IC₅₀ of 5.4 nM. O-GlcNAcase-IN-6 inhibits OGA activity, thereby increasing the level of O-GlcNAc glycosylation in brain tissues. O-GlcNAcase-IN-6 can be used for the research of Alzheimer's disease .

Cat. No.	Product Name	Type

HY-W039921

2-[(Azidoacety)amino]-2-deoxy-D-galactose N-Azidoacetylgalactosamine; GalNAz	Biochemical Assay Reagents
2-[(Azidoacety)amino]-2-deoxy-D-galactose targets O-GlcNAc-modified proteins. By detecting and targeting O-GlcNAc-modified proteins, 2-[(Azidoacety)amino]-2-deoxy-D-galactose can serve as a chemical tag for intracellular sugar chain metabolism .

HY-W039939

2-Azido-2-deoxy-D-glucose, 98% 2-ADG, 98%	Biochemical Assay Reagents
2-Azido-2-deoxy-D-glucose, 98% (2-ADG, 98%) is a substrate of O-GlcNAc transferase (OGT). 2-Azido-2-deoxy-D-glucose, 98% can be transferred from UDP-GlcAz to proteins in vitro via OGT mediation. When delivered as AcGlcAz, 2-Azido-2-deoxy-D-glucose, 98% enables the labeling and investigation of O-GlcNAc-modified nuclear and cytoplasmic proteins in cells. 2-Azido-2-deoxy-D-glucose, 98% undergoes strain-promoted [3+2] azide-alkyne cycloaddition (SPAAC) with technetium- ^99m-labeled dibenzocyclooctyne derivatives in vivo. 2-Azido-2-deoxy-D-glucose, 98% can be used in sarcoma-related research .

2-Azido-2-deoxy-D-glucose, 98%

2-ADG, 98%

Biochemical Assay Reagents

2-Azido-2-deoxy-D-glucose, 98% (2-ADG, 98%) is a substrate of O-GlcNAc transferase (OGT). 2-Azido-2-deoxy-D-glucose, 98% can be transferred from UDP-GlcAz to proteins in vitro via OGT mediation. When delivered as AcGlcAz, 2-Azido-2-deoxy-D-glucose, 98% enables the labeling and investigation of O-GlcNAc-modified nuclear and cytoplasmic proteins in cells. 2-Azido-2-deoxy-D-glucose, 98% undergoes strain-promoted [3+2] azide-alkyne cycloaddition (SPAAC) with technetium- ^99m-labeled dibenzocyclooctyne derivatives in vivo. 2-Azido-2-deoxy-D-glucose, 98% can be used in sarcoma-related research .

Cat. No.	Product Name	Target	Research Area

HY-P4752

*KWKHGAEIVYKSPVV-{S(GlcNAc-β-D)}-GDTSPRHLSNVK-{K(biotinyl)}-NH2*	Peptides	Others
KWKHGAEIVYKSPVV-{S(GlcNAc-β-D)}-GDTSPRHLSNVK-{K(biotinyl)}-NH2 is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P5747

Glycocin F	Peptides	Others
Glycocin F is a antimicrobial peptide with activity against L. plantarum .

HY-P10572

HG1 Toxin	Ser/Thr Protease Potassium Channel	Inflammation/Immunology Endocrinology
HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, which has the activity of inhibiting potassium channel Kv1.3. HG1 Toxin also has the activity of inhibiting trypsin (K_i=107 nM) and can be used in the study of autoimmune diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3677

Dammarenediol II	Triterpenes Structural Classification other families Boswellia freerana Terpenoids Plants Source Classification	OGT Akt mTOR GSK-3 Reactive Oxygen Species (ROS) Apoptosis PARP MDM-2/p53
Dammarenediol II is a ginsenoside precursor . Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy .

HY-139793

UDP-glucosamine disodium	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	OGT Endogenous Metabolite
UDP-glucosamine (UDP-GlcNAc) disodium is a substrate for O-GlcNAc transferase, which catalyzes the attachment of O-GlcNAc to proteins. O-GlcNAcase catalyzes the removal of O-GlcNAc from proteins. UDP-glucosamine (UDP-GlcNAc) disodium is the end product of the hexosamine biosynthesis pathway, which is regulated primarily by glucose-6-phosphate-Glutamine:fructose-6-phosphate amidotransferase (GFAT) .

HY-148596

UDP-GlcNAc UDP-N-Acetyl-D-glucosamine; Uridine diphospho-N-acetylglucosamine; UDP-N-acetylglucosamine	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite P2Y Receptor Drug Intermediate Glycosyltransferase
UDP-GlcNAc (UDP-N-Acetyl-D-glucosamine) is an important component and precursor of bacterial peptidoglycan. UDP-GlcNAc is a nucleotide sugar used by Glycosyltransferases to synthesize glycoproteins, glycosaminoglycans, glycolipids, and glycoRNA. UDP-GlcNAc also serves as the donor substrate for forming O-GlcNAc, a dynamic intracellular protein modification involved in diverse signaling and disease processes. UDP-GlcNAc is the sugar nucleotide donor for the synthesis of O-GlcNAc modified proteins. UDP-GlcNAc also acts as a full agonist of the P2Y₁₄ receptor and inhibits the formation of cAMP. UDP-GlcNAc can be used in studies related to bacterial infections .

Species:	Human (2)
Tag:	SUMO (1) His (2) Myc (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705511

	OGT Protein, Human (His, Myc) O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine transferase 110 kDa subunit	Human	E. coli

HY-P703650

	OGT Protein, Human (His) 1 Publications Verification UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine transferase 110 kDa subunit (OGT); OGT	Human	E. coli
	OGT Protein, Human (His) is the recombinant human-derived OGT protein, expressed by E. coli, with N-6*His & N-SUMO tag.

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Cat. No.	Product Name	Chemical Structure

HY-112174S

*UDP-GlcNAc-13C disodium*
UDP-GlcNAc- ¹³C (disodium) is the ¹³C labeled UDP-GlcNAc Disodium Salt. UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (O .

Cat. No.	Product Name		Classification

HY-W423080

TAMRA alkyne,5-isomer		Alkynes
TAMRA alkyne, 5-isomer (Compound 3) is an alkyne derivative of TAMRA and can be used for the enrichment, in-gel fluorescence detection, and identification of O-GlcNAc-modified proteins. TAMRA alkyne, 5-isomer contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Azide groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-W039921

2-[(Azidoacety)amino]-2-deoxy-D-galactose N-Azidoacetylgalactosamine; GalNAz		Azide
2-[(Azidoacety)amino]-2-deoxy-D-galactose targets O-GlcNAc-modified proteins. By detecting and targeting O-GlcNAc-modified proteins, 2-[(Azidoacety)amino]-2-deoxy-D-galactose can serve as a chemical tag for intracellular sugar chain metabolism .

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O-GlcNAc

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Natural
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