35 Results for "

O-GlcNAc

" in MedChemExpress (MCE) Product Catalog:
Products (35)

35 Results for "O-GlcNAc" in MCE Product Catalog:

  • Targets Recommended:
56
56 Publications Verification
Cat. No.: HY-12588
CAS No.: 1009816-48-1
Purity:  99.99%
Target:  

OGA Autophagy

Research Areas:  

Cancer

Thiamet G is a potent and selective inhibitor of O-GlcNAcase (OGA), which acts to remove O-GlcNAc from modified proteins, with Ki of 20 nM for human OGA.
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51
51 Cited Publications
Cat. No.: HY-119738
CAS No.: 1681056-61-0
Purity:  99.90%
Target:  

OGT Acyltransferase

Research Areas:  

Metabolic Disease

OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .
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32
32 Cited Publications
Cat. No.: HY-114361
CAS No.: 2260791-14-6
Purity:  99.69%
Target:  

OGT Acyltransferase

Research Areas:  

Metabolic Disease

OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells.
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8
8 Cited Publications
Cat. No.: HY-112174
CAS No.: 91183-98-1
Purity:  99.92%
Synonyms: UDP-α-D-N-Acetylglucosamine disodium
Target:  

OGT

Research Areas:  

Metabolic Disease

UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (OGT).
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Cat. No.: HY-N3677
CAS No.: 14351-29-2
Dammarenediol II is a ginsenoside precursor . Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy .
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Cat. No.: HY-148113
CAS No.: 1681056-62-1
Purity:  ≥98.0%
Target:  

OGT

Research Areas:  

Others

PG 34 is a weak O-GlcNAc transferase (OGT) inhibitor (IC50=68 μM), and a close structural analog of OSMI-1 (HY-119738) .
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Cat. No.: HY-W423080
CAS No.: 945928-17-6
Research Areas:  

Others

TAMRA alkyne, 5-isomer (Compound 3) is an alkyne derivative of TAMRA and can be used for the enrichment, in-gel fluorescence detection, and identification of O-GlcNAc-modified proteins. TAMRA alkyne, 5-isomer contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Azide groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .
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Cat. No.: HY-139793
CAS No.: 1355005-51-4
Purity:  99.43%
UDP-glucosamine (UDP-GlcNAc) disodium is a substrate for O-GlcNAc transferase, which catalyzes the attachment of O-GlcNAc to proteins. O-GlcNAcase catalyzes the removal of O-GlcNAc from proteins. UDP-glucosamine (UDP-GlcNAc) disodium is the end product of the hexosamine biosynthesis pathway, which is regulated primarily by glucose-6-phosphate-Glutamine:fructose-6-phosphate amidotransferase (GFAT) .
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Cat. No.: HY-W039921
CAS No.: 869186-83-4
Synonyms: N-Azidoacetylgalactosamine; GalNAz
2-[(Azidoacety)amino]-2-deoxy-D-galactose targets O-GlcNAc-modified proteins. By detecting and targeting O-GlcNAc-modified proteins, 2-[(Azidoacety)amino]-2-deoxy-D-galactose can serve as a chemical tag for intracellular sugar chain metabolism .
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Cat. No.: HY-148596
CAS No.: 528-04-1
Synonyms: UDP-N-Acetyl-D-glucosamine; Uridine diphospho-N-acetylglucosamine; UDP-N-acetylglucosamine
UDP-GlcNAc (UDP-N-Acetyl-D-glucosamine) is an important component and precursor of bacterial peptidoglycan. UDP-GlcNAc is a nucleotide sugar used by Glycosyltransferases to synthesize glycoproteins, glycosaminoglycans, glycolipids, and glycoRNA. UDP-GlcNAc also serves as the donor substrate for forming O-GlcNAc, a dynamic intracellular protein modification involved in diverse signaling and disease processes. UDP-GlcNAc is the sugar nucleotide donor for the synthesis of O-GlcNAc modified proteins. UDP-GlcNAc also acts as a full agonist of the P2Y14 receptor and inhibits the formation of cAMP. UDP-GlcNAc can be used in studies related to bacterial infections .
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Cat. No.: HY-W039939
CAS No.: 56883-39-7
Synonyms: 2-ADG, 98%
2-Azido-2-deoxy-D-glucose, 98% (2-ADG, 98%) is a substrate of O-GlcNAc transferase (OGT). 2-Azido-2-deoxy-D-glucose, 98% can be transferred from UDP-GlcAz to proteins in vitro via OGT mediation. When delivered as AcGlcAz, 2-Azido-2-deoxy-D-glucose, 98% enables the labeling and investigation of O-GlcNAc-modified nuclear and cytoplasmic proteins in cells. 2-Azido-2-deoxy-D-glucose, 98% undergoes strain-promoted [3+2] azide-alkyne cycloaddition (SPAAC) with technetium- 99m-labeled dibenzocyclooctyne derivatives in vivo. 2-Azido-2-deoxy-D-glucose, 98% can be used in sarcoma-related research .
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Cat. No.: HY-149552
CAS No.: 67561-97-1
Target:  

OGT

Research Areas:  

Cancer

Ac4-5SGlcNAc is an O-GlcNAc transferase (OGT) inhibitor. Ac4-5SGlcNAc converts intracellularly to UDP-5SGlcNAc, which competes with native UDP-GlcNAc (HY-148596) to block OGT catalytic activity, reduces cellular UDP-GlcNAc pools, and limits global protein O-GlcNAcylation. Ac4-5SGlcNAc reduces OGA levels via feedback, alters lectin signal intensities and glycan-related band masses. Ac4-5SGlcNAc can be used for the research of breast cancer .
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Cat. No.: HY-125278
CAS No.: 2411972-44-4
Target:  

OGT

Research Areas:  

Others

OGT-IN-4 (compound 4a) is an O-GlcNAc transferase (OGT) inhibitor with a Kd of 8 nM. OGT-IN-4 can be utilized in OGT related research .
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Cat. No.: HY-101548
CAS No.: 371215-02-0
Purity:  98.14%
Target:  

OGT

Research Areas:  

Metabolic Disease

OGT-IN-1 (Compound 5) is a potent OGT inhibitor. OGT-IN-1 inhibits sOGT and ncOGT with IC50s of 27 and 10 μM, respectively .
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Cat. No.: HY-P4752
CAS No.: 2022974-40-7
Target:  

Inhibitory Antibodies

Research Areas:  

Others

KWKHGAEIVYKSPVV-{S(GlcNAc-β-D)}-GDTSPRHLSNVK-{K(biotinyl)}-NH2 is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
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Cat. No.: HY-P3795
CAS No.: 361443-81-4
Target:  

HSV

Research Areas:  

Infection Neurological Disease

G2-Peptide is a 3-O-sulfated heparan sulfate (3-OS HS) binder and antiviral agent. G2-Peptide blocks herpesvirus attachment, entry, cell-to-cell spread and syncytium formation, and reduces viral protein translocation. G2-Peptide exhibits antiviral activity against both HSV-1 and HSV-2. G2-Peptide inhibits neural activity and impairs synapse assembly. G2-Peptide can be used in the research of genital herpes, ocular herpes infection and keratitis .
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Cat. No.: HY-112174S
Purity:  96.99%
Synonyms: UDP-α-D-N-Acetylglucosamine-13C disodium
UDP-GlcNAc- 13C (disodium) is the 13C labeled UDP-GlcNAc Disodium Salt. UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (O .
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Cat. No.: HY-119738A
CAS No.: 2748153-92-4
Purity:  96.51%
Target:  

OGT Acyltransferase

Research Areas:  

Metabolic Disease

(Rac)-OSMI-1 is the racemate of OSMI-1. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .
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Cat. No.: HY-RS09765
Research Areas:  

Others

OGT Human Pre-designed siRNA Set A contains three designed siRNAs for OGT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-E70880
Synonyms: EndoCC N180H
Target:  

Glycosidase

Research Areas:  

Others

Endoglycosidase CC (N180H mutant) (EndoCC N180H) is a mutant endoglycosidase, which efficiently and specifically recognizes core fucose and O-GlcNAc .
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