PGC

By Targets:	PGC-1α (9) Adrenergic Receptor (1) Apoptosis (1) Autophagy (3) Endogenous Metabolite (1) Epigenetic Reader Domain (2) Estrogen Receptor/ERR (1) Guanylate Cyclase (1) PKA (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Metabolic Disease (6) Neurological Disease (2)

Targets Recommended: PGC-1α

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3455

Ac-SVVVRT-NH2	PGC-1α	Metabolic Disease Cancer
Ac-SVVVRT-NH2 is a *PGC-1α* modulator that modulates the activity of the human PGC-1α promoter (114%). Ac-SVVVRT-NH2 increases PGC-1α mRNA (125%) and accumulation of intracellular lipids (128%) in subcutaneous human adipocytes. Ac-SVVVRT-NH2 can be used in the research of diseases which is modulated by PGC-1α .

HY-113960

ERRα antagonist-1	Estrogen Receptor/ERR	Cancer
ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC₅₀ values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1 .

HY-101491

SR-18292 Maximum Cited Publications 42 Publications Verification	PGC-1α Autophagy	Metabolic Disease
SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.

HY-17538

ZLN005

25+ Cited Publications

PGC-1α Autophagy Metabolic Disease

ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) .

ZLN005 25+ Cited Publications	PGC-1α Autophagy	Metabolic Disease
ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) .

HY-RS10380

PGC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PGC Human Pre-designed siRNA Set A contains three designed siRNAs for PGC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PGC Human Pre-designed siRNA Set A PGC Human Pre-designed siRNA Set A

HY-N7439

Mogroside VI B	PGC-1α	Metabolic Disease
Mogroside VI B, a cucurbitane glucoside, separated from the crude extract of Siraitia grosvenorii. Mogroside VI B shows effect on activating *PGC-1α* transcription .

HY-P3624

Cenderitide	Guanylate Cyclase	Cardiovascular Disease
Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide activates both *pGC-A* and *pGC-B, activates the second messenger cGMP, suppresses aldosterone*, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research .

HY-17538S

ZLN005-d4	PGC-1α Autophagy	Metabolic Disease
ZLN005-d₄ is deuterium labeled ZLN005. ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α)[1].

HY-N12011

11-Oxoisomogroside V	PGC-1α	Others
11-Oxoisomogroside V (compound 3) is a cucurbitacin isolated from the crude extract of Luo Han Guo. 11-Oxoisomogroside V activates the transcriptional activity of PGC-1α. In the luciferase experiment, the results showed that 10 μM and 20 μM 11-Oxoisomogroside V could increase the luciferase activity to 133.79% and 143.81% .

HY-P5763

Phoenixin-20 PNX-20	Epigenetic Reader Domain PGC-1α	Neurological Disease
Phoenixin-20 (PNX-20) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 promotes neuronal mitochondrial biogenesis via *CREB-PGC-1α* pathway. Phoenixin-20 has anxiolytic effect .

HY-P5763A

Phoenixin-20 TFA PNX-20 TFA	Epigenetic Reader Domain PGC-1α	Neurological Disease
Phoenixin-20 (TFA) (PNX-20 (TFA)) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 (TFA) promotes neuronal mitochondrial biogenesis via *CREB-PGC-1α* pathway. Phoenixin-20 (TFA) has anxiolytic effect .

HY-N0378

D-Mannitol 4 Publications Verification Mannitol; Mannite	Endogenous Metabolite Apoptosis Adrenergic Receptor PGC-1α PKA	Metabolic Disease Cancer
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), *PGC1α* and PKA induced by means of white fat cells into brown fat cells .

Cat. No.	Product Name	Target	Research Area

HY-P3455

Ac-SVVVRT-NH2	PGC-1α	Metabolic Disease Cancer
Ac-SVVVRT-NH2 is a *PGC-1α* modulator that modulates the activity of the human PGC-1α promoter (114%). Ac-SVVVRT-NH2 increases PGC-1α mRNA (125%) and accumulation of intracellular lipids (128%) in subcutaneous human adipocytes. Ac-SVVVRT-NH2 can be used in the research of diseases which is modulated by PGC-1α .

HY-P5763

Phoenixin-20 PNX-20	Epigenetic Reader Domain PGC-1α	Neurological Disease
Phoenixin-20 (PNX-20) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 promotes neuronal mitochondrial biogenesis via *CREB-PGC-1α* pathway. Phoenixin-20 has anxiolytic effect .

HY-P3624

Cenderitide	Guanylate Cyclase	Cardiovascular Disease
Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide activates both *pGC-A* and *pGC-B, activates the second messenger cGMP, suppresses aldosterone*, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research .

HY-P5763A

Phoenixin-20 TFA PNX-20 TFA	Epigenetic Reader Domain PGC-1α	Neurological Disease
Phoenixin-20 (TFA) (PNX-20 (TFA)) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 (TFA) promotes neuronal mitochondrial biogenesis via *CREB-PGC-1α* pathway. Phoenixin-20 (TFA) has anxiolytic effect .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7439

Mogroside VI B	Triterpenes Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields	PGC-1α
Mogroside VI B, a cucurbitane glucoside, separated from the crude extract of Siraitia grosvenorii. Mogroside VI B shows effect on activating *PGC-1α* transcription .

HY-N0378

D-Mannitol 4 Publications Verification Mannitol; Mannite	Structural Classification Natural Products Microorganisms other families Classification of Application Fields Source classification Metabolic Disease Plants Endogenous metabolite Disease Research Fields Sweeteners Food Research	Endogenous Metabolite Apoptosis Adrenergic Receptor PGC-1α PKA
D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), *PGC1α* and PKA induced by means of white fat cells into brown fat cells .

HY-N12011

11-Oxoisomogroside V	Structural Classification Polysaccharides Source classification Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Saccharides	PGC-1α
11-Oxoisomogroside V (compound 3) is a cucurbitacin isolated from the crude extract of Luo Han Guo. 11-Oxoisomogroside V activates the transcriptional activity of PGC-1α. In the luciferase experiment, the results showed that 10 μM and 20 μM 11-Oxoisomogroside V could increase the luciferase activity to 133.79% and 143.81% .

Species:	Human (2) Rat (1)
Tag:	His (3)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P77132

	*Pepsinogen C/PGC* Protein, Human (HEK293, His)** Gastricsin; Pepsinogen C; PGC; PEPC	Human	HEK293
	Pepsinogen C/PGC protein hydrolyzes various proteins, playing a crucial role in digestion by breaking them down into smaller peptides. Its proficiency in protein hydrolysis contributes to the initial stages of digestion, making it vital in the overall digestive cascade. Pepsinogen C/PGC Protein, Human (HEK293, His) is the recombinant human-derived Pepsinogen C/PGC protein, expressed by HEK293 , with C-His labeled tag. The total length of Pepsinogen C/PGC Protein, Human (HEK293, His) is 372 a.a., with molecular weight of ~41 kDa.

HY-P76538

	*Pepsinogen C/PGC* Protein, Rat (HEK293, His)** Gastricsin; Pepsinogen C; PGC; PEPC	Rat	HEK293
	Pepsinogen C (PGC) functions as an enzyme with the ability to hydrolyze a diverse range of proteins. Pepsinogen C/PGC Protein, Rat (HEK293, His) is the recombinant rat-derived Pepsinogen C/PGC protein, expressed by HEK293 , with C-His labeled tag. The total length of Pepsinogen C/PGC Protein, Rat (HEK293, His) is 376 a.a., with molecular weight of ~43 kDa.

HY-P77131

	*Pepsinogen C/PGC* Protein, Human (His)** Gastricsin; Pepsinogen C; PGC; PEPC	Human	E. coli
	Pepsinogen C/PGC protein hydrolyzes various proteins, playing a crucial role in digestion by breaking them down into smaller peptides. Its proficiency in protein hydrolysis contributes to the initial stages of digestion, making it vital in the overall digestive cascade. Pepsinogen C/PGC Protein, Human (His) is the recombinant human-derived Pepsinogen C/PGC protein, expressed by E. coli , with N-His labeled tag. The total length of Pepsinogen C/PGC Protein, Human (His) is 87 a.a., with molecular weight of ~10 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-17538S

ZLN005-d4

ZLN005-d₄ is deuterium labeled ZLN005. ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α)[1].

ZLN005-d4
ZLN005-d₄ is deuterium labeled ZLN005. ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α)[1].

Cat. No.	Product Name	Application	Reactivity

HY-P80783

PGC1 alpha Antibody PPARGC1A; LEM6; PGC1; PGC1A; PPARGC1; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ligand effect modulator 6	WB	Human, Mouse, Rat
PGC1 alpha Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 91 kDa, targeting to PGC1 alpha. It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P81666

PGC1 beta Antibody (YA1411)

PERC; PGC1; PPARGC1; Ppargc1b
WB, IP Human, Mouse, Rat

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PGC

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