Pepsinogen C/PGC Protein, Rat (HEK293, His)

Pepsinogen C (PGC) functions as an enzyme with the ability to hydrolyze a diverse range of proteins. Pepsinogen C/PGC Protein, Rat (HEK293, His) is the recombinant rat-derived Pepsinogen C/PGC protein, expressed by HEK293 , with C-His labeled tag. The total length of Pepsinogen C/PGC Protein, Rat (HEK293, His) is 376 a.a., with molecular weight of ~43 kDa.

Pepsinogen C (PGC) is an enzyme that functions as a precursor to the digestive enzyme pepsin. PGC possesses the ability to hydrolyze a diverse range of proteins. This enzyme is primarily synthesized and secreted by the gastric chief cells in the stomach lining. Once released into the acidic environment of the stomach, PGC undergoes cleavage to form pepsin, an active protease responsible for breaking down dietary proteins into smaller peptides. The conversion of PGC to pepsin is facilitated by the low pH of the stomach, triggering the activation of this zymogen. The role of PGC in the digestive process is crucial for the initial breakdown of ingested proteins, enabling their subsequent digestion and absorption in the gastrointestinal tract. Understanding the activation and function of PGC contributes to insights into the intricate mechanisms of protein digestion and gastric physiology.

Rat

HEK293

C-His

P04073 (S17-V392)

24864  [NCBI]

Approximately 43 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.