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  3. ERRα antagonist-1

ERRα antagonist-1 

Cat. No.: HY-113960 Purity: >98.0%
Handling Instructions

ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1.

For research use only. We do not sell to patients.

ERRα antagonist-1 Chemical Structure

ERRα antagonist-1 Chemical Structure

CAS No. : 1072145-33-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 94 In-stock
Estimated Time of Arrival: December 31
5 mg USD 85 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 300 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 Get quote
100 mg   Get quote  
200 mg   Get quote  

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Description

ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1[1].

IC50 & Target[1]

ERRα

 

Molecular Weight

377.53

Formula

C₂₁H₁₉N₃S₂

CAS No.

1072145-33-5

SMILES

C12=CC=CC=C1C(/N=C3SCCN\3C4=NCCS4)C5=CC=CC=C5C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 7.14 mg/mL (18.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6488 mL 13.2440 mL 26.4880 mL
5 mM 0.5298 mL 2.6488 mL 5.2976 mL
10 mM 0.2649 mL 1.3244 mL 2.6488 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.71 mg/mL (1.88 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ERRα antagonist-1ERRα antagonist1ERRα antagonist 1Estrogen Receptor/ERRInhibitorinhibitorinhibit

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Product name:
ERRα antagonist-1
Cat. No.:
HY-113960
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