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Pathways Recommended:	PI3K/Akt/mTOR

Results for "

PI3K/AKT-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PI3K (7) ADC Payload (1) Akt (13) AMPK (1) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (10) Autophagy (3) Bacterial (1) Bcl-2 Family (1) c-Fms (1) Caspase (1) CDK (1) Endogenous Metabolite (1) ERK (1) FOXO (1) GLUT (3) HIV (3) Isotope-Labeled Compounds (2) JNK (1) MALT1 (1) Mitochondrial Metabolism (2) Mitophagy (1) MMP (1) mTOR (1) NF-κB (4) p38 MAPK (1) Parasite (3) PDK-1 (1) PPAR (2) Reactive Oxygen Species (ROS) (2) Reference Standards (2) RET (1) Ribosomal S6 Kinase (RSK) (1) Sirtuin (1) TNF Receptor (1) Tyrosinase (1)
By Research Areas:	Cancer (15) Cardiovascular Disease (1) Endocrinology (1) Infection (4) Inflammation/Immunology (3) Metabolic Disease (5) Neurological Disease (1)
Oligonucleotides:	Phospholipids (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: PI3K

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13685

Miltefosine 10+ Cited Publications HePC; Hexadecyl phosphocholINe	Akt HIV Parasite	Infection Cancer
Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the *PI3K/Akt* activity ^[3] . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .

HY-144806

*PI3K/AKT-IN-1* Maximum Cited Publications 15 Publications Verification	PI3K Akt Apoptosis	Cancer
PI3K/AKT-IN-1 is an effective *PI3K/AKT* dual inhibitor (IC₅₀ of 6.99, 4.01 and 3.36 μM for PI3Kγ, PI3Kδ and AKT, respectively). PI3K/AKT-IN-1 has anticancer activity and acts by inhibiting PI3K/AKT axis and inducing caspase 3 dependent apoptosis ^[1].

HY-13425

Deguelin 10+ Cited Publications (-)-DeguelIN; (-)-cis-DeguelIN	Akt Autophagy Apoptosis	Cancer
Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.

HY-N0616

Trifolirhizin	Tyrosinase TNF Receptor Bacterial Apoptosis Autophagy AMPK mTOR ERK NF-κB	Infection Metabolic Disease Inflammation/Immunology Cancer
Trifolirhizin is a pterocarpan flavonoid found in the roots of Sophora flavescens. Trifolirhizin is a tyrosinase inhibitor with an IC₅₀ value of 506.77 μM. Trifolirhizin reduces intracellular melanin production and modulates multiple signaling pathways including NFκB-MAPK, AMPK/mTOR, PI3K/Akt, MAPK-NFATc1 and EGFR-MAPK. Trifolirhizin targets biological molecules including PTK6 and COX-2, inhibits the activities of hyaluronidase, collagenase and elastase, induces apoptosis, autophagy and cell cycle arrest, and suppresses the proliferation, migration and invasion of cancer cells. Trifolirhizin exerts diverse pharmacological effects including anti-inflammatory, anti-asthmatic, bone-protective, renoprotective, antibacterial, antifungal, hepatoprotective, antiplatelet, estrogenic and wound-healing activities. Trifolirhizin can be used to investigate a broad range of malignant, inflammatory, metabolic and infectious disorders ^[1] ^[3].

HY-N0479

Licarin B 1 Publications Verification (-)-LicarIN B	PPAR GLUT	Metabolic Disease
Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway ^[3].

HY-118020A

Loliolide Loliolid; Digiprolactone	Endogenous Metabolite Caspase PI3K Apoptosis Akt Sirtuin Reactive Oxygen Species (ROS) NF-κB MMP	Neurological Disease Cancer
Loliolide (Loliolid) is a β-carotene metabolite. Loliolide reduces caspase 3, 8, 9 expression, enhances *PI3K, AKT, SIRT1*, inhibits ROS, apoptosis, and blocks NF-κB p65 nuclear translocation. Loliolide protects mitochondria, reduces oxidative stress, and increases cell viability in neuroblastoma cells. Loliolide can be used for the research of UV-induced skin damage and Parkinson’s disease ^[1] ^[3].

HY-N3312

Matairesinol	p38 MAPK JNK NF-κB	Metabolic Disease Inflammation/Immunology Cancer
Matairesinol is an orally active bioactive compound with anti-inflammatory, antioxidant and anticancer activities. Matairesinol inhibits the phosphorylation of MAPK, JNK and NF-κB, downregulates RANKL-induced NFATc1 expression and activity, and suppresses the activation of the *PI3K/AKT/FOXO1* pathway. Matairesinol can be used in research related to sepsis-mediated brain injury, osteoporosis, heart failure, atopic dermatitis and cancer ^[1] ^[3] .

HY-121012

(rac)-AG-205	NF-κB Akt	Endocrinology
(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway .

HY-16461

Solenopsin (-)-SolenopsIN A	Akt Ribosomal S6 Kinase (RSK) PI3K PDK-1 FOXO Mitophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism	Cardiovascular Disease
Solenopsin ((-)-Solenopsin A) is an ATP-competitive and selective *Akt-1* inhibitor with an IC₅₀ of 5-10 μM, and also acts as an *RSK1* inhibitor. Solenopsin inhibits the activities of *PDK1* in lipid rafts, downregulates *PI3K, blocks PI3K-dependent* generation of 3-phosphoinositides, and suppresses the phosphorylation of *FOXO1a. Solenopsin induces Mitophagy* and ROS production, reduces mitochondrial oxygen consumption, and exhibits antiproliferative and antiangiogenic activities. Solenopsin can be used in research related to hyperproliferative skin diseases and malignant diseases ^[1] .

HY-131055

Mytoxin B	ADC Payload PI3K Apoptosis	Cancer
Mytoxin B is an ADC cytotoxin. Mytoxin B is a satratoxin-type trichothecene macrolide and is similar to the effect of LY294002 (HY-10108). Mytoxin B induces cell apoptosis via PI3K/Akt pathway .

HY-13685R

Miltefosine (Standard) HePC (Standard); Hexadecyl phosphocholINe (Standard)	Akt HIV Parasite Reference Standards	Infection Cancer
Miltefosine (Standard) is the analytical standard of Miltefosine. This product is intended for research and analytical applications. Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity ^[3] . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .

HY-173007

ALK/PI3K/AKT-IN-1	Akt PI3K Anaplastic lymphoma kinase (ALK) CDK Apoptosis Mitochondrial Metabolism	Cancer
ALK/PI3K/AKT-IN-1 (Compound 45) inhibits the proliferation of cancer cell A549, H1975 and PC9 with an IC₅₀ of 0.44, 0.83 and 1.51 μM. ALK/PI3K/AKT-IN-1 increases the expression of p21 and p27, inhibits the activity of CDK2 and p-Rb, arrests the cell cycle at G1 phase. ALK/PI3K/AKT-IN-1 inhibits the *ALK/PI3K/AKT* signaling pathway, promotes the depolarization of mitochondrial membrane potential, and inducing apoptosis in A549 cell. ALK/PI3K/AKT-IN-1 inhibits the formation and growth of A549 cell spheroids ^[1].

HY-13425R

Deguelin (Standard) (-)-DeguelIN (Standard); (-)-cis-DeguelIN (Standard)	Akt Autophagy Apoptosis Reference Standards	Cancer
Deguelin (Standard) is the analytical standard of Deguelin. This product is intended for research and analytical applications. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.

HY-E70789

BCR-RET Recombinant Human Active Protein Kinase	RET	Others
BCR-RET Recombinant Human Active Protein Kinase is a BCR-RET fusion protein in hematopoietic malignancies. BCR-RET overactivates the Ras-ERK pathway, in addition to JAK/STAT3 and PI3K/AKT pathways .

HY-161144

AKT-IN-21	Akt Apoptosis	Cancer
AKT-IN-21 (compound C36) is a potent AKT inhibitor with broad-spectrum cytotoxicity and anticancer activity. AKT-IN-21 also blocks the cell cycle and induces apoptosis of cancer cells by down-regulating the PI3K/AKT pathway .

HY-P4790

Acetyl-Exenatide	PI3K Akt	Metabolic Disease
Acetyl-Exenatideyes is an acetylated derivative of Exenatide. Exenatide has the function similar to insulin, which can be used for research of type 2 diabetes. Exenatide can promote Th17 differentiation, inhibits Tregs differentiation, downregulates PI3K/Akt/FoxO1 phosphorylation ^[1].

HY-158050

PXB17	c-Fms	Cancer
PXB17 can inhibit *CSF1R* (IC₅₀ = 1.7 nM) by blocking the activation of PI3K/ AKT/mTORC1 signaling. PXB17 is orally effective. PXB17 significantly inhibits the growth of CRC, improves PD-1 mAb efficacy and reduces tumor recurrence in CRC ^[1].

HY-13685S1

Miltefosine-d4 HePC-d₄; Hexadecyl phosphocholINe-d₄	Isotope-Labeled Compounds Akt Parasite HIV	Infection Cancer
Miltefosine-d₄ (HePC-d₄) is deuterium labeled Miltefosine. Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the *PI3K/Akt* activity ^[3] . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .

HY-N0479S

Licarin B-d4	Isotope-Labeled Compounds PPAR GLUT	Metabolic Disease
Licarin B-d₄ is the deuterium labeled Licarin B (HY-N0479). Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway ^[3].

HY-162268

MALT1-IN-13	MALT1 Apoptosis	Inflammation/Immunology Cancer
MALT1-IN-13 (compound 10m) is inhibitor for mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), which to binds MALT1 protease covalently and irreversibly, inhibits MALT1 with the IC₅₀ of 1.7 μM. MALT1-IN-13 inhibits proliferation against ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1. MALT1-IN-13 regulates mTOR and PI3K-Akt pathways .

HY-183069

FKL-137	GLUT PI3K Akt Apoptosis Bcl-2 Family	Cancer
FKL-137 is a *GLUT1* and *PI3K/AKT* signaling pathway inhibitor. FKL-137 binds to GLUT1, reduces glucose uptake and lactate secretion, downregulates glucose metabolism-related proteins, and inhibits erythroleukemia cell proliferation. FKL-137 downregulates *PI3K, p-PI3K, AKT, p-AKT* levels, disrupts the PI3K/AKT-GLUT1 positive feedback loop, and suppresses erythroleukemia cell proliferation. FKL-137 induces apoptosis via upregulated Bax, Cleaved-PARP and downregulated Bcl-2, PARP. FKL-137 can be used for the research of erythroleukemia ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P4790

Acetyl-Exenatide	PI3K Akt	Metabolic Disease
Acetyl-Exenatideyes is an acetylated derivative of Exenatide. Exenatide has the function similar to insulin, which can be used for research of type 2 diabetes. Exenatide can promote Th17 differentiation, inhibits Tregs differentiation, downregulates PI3K/Akt/FoxO1 phosphorylation ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13425

Deguelin 10+ Cited Publications (-)-DeguelIN; (-)-cis-DeguelIN	Flavonoids Classification of Application Fields Leguminosae Isoflavanones Derris trifoliata Lour. Plants Disease Research Fields Biological Pesticide Research Source Classification Cancer Agricultural Research	Akt Autophagy Apoptosis
Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.

HY-N0616

Trifolirhizin	Structural Classification Flavonoids Classification of Application Fields Leguminosae Trifolium pratense Linn. Sophora flavescens Aiton Plants Other Flavonoids Inflammation/Immunology Disease Research Fields Source Classification Cancer	Tyrosinase TNF Receptor Bacterial Apoptosis Autophagy AMPK mTOR ERK NF-κB
Trifolirhizin is a pterocarpan flavonoid found in the roots of Sophora flavescens. Trifolirhizin is a tyrosinase inhibitor with an IC₅₀ value of 506.77 μM. Trifolirhizin reduces intracellular melanin production and modulates multiple signaling pathways including NFκB-MAPK, AMPK/mTOR, PI3K/Akt, MAPK-NFATc1 and EGFR-MAPK. Trifolirhizin targets biological molecules including PTK6 and COX-2, inhibits the activities of hyaluronidase, collagenase and elastase, induces apoptosis, autophagy and cell cycle arrest, and suppresses the proliferation, migration and invasion of cancer cells. Trifolirhizin exerts diverse pharmacological effects including anti-inflammatory, anti-asthmatic, bone-protective, renoprotective, antibacterial, antifungal, hepatoprotective, antiplatelet, estrogenic and wound-healing activities. Trifolirhizin can be used to investigate a broad range of malignant, inflammatory, metabolic and infectious disorders ^[1] ^[3].

HY-N0479

Licarin B 1 Publications Verification (-)-LicarIN B	Classification of Application Fields Simple Phenylpropanols Metabolic Disease Myristicaceae Phenylpropanoids Plants Myristica fragrans Houtt. Disease Research Fields Source Classification	PPAR GLUT
Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway ^[3].

HY-118020A

Loliolide Loliolid; Digiprolactone	Natural Products Classification of Application Fields Metabolic Disease Plants Compositae Millettia usaramensis Taub. Disease Research Fields Source Classification	Endogenous Metabolite Caspase PI3K Apoptosis Akt Sirtuin Reactive Oxygen Species (ROS) NF-κB MMP
Loliolide (Loliolid) is a β-carotene metabolite. Loliolide reduces caspase 3, 8, 9 expression, enhances *PI3K, AKT, SIRT1*, inhibits ROS, apoptosis, and blocks NF-κB p65 nuclear translocation. Loliolide protects mitochondria, reduces oxidative stress, and increases cell viability in neuroblastoma cells. Loliolide can be used for the research of UV-induced skin damage and Parkinson’s disease ^[1] ^[3].

HY-N3312

Matairesinol	Infection Structural Classification other families Classification of Application Fields Anti-aging Lignans Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification	p38 MAPK JNK NF-κB
Matairesinol is an orally active bioactive compound with anti-inflammatory, antioxidant and anticancer activities. Matairesinol inhibits the phosphorylation of MAPK, JNK and NF-κB, downregulates RANKL-induced NFATc1 expression and activity, and suppresses the activation of the *PI3K/AKT/FOXO1* pathway. Matairesinol can be used in research related to sepsis-mediated brain injury, osteoporosis, heart failure, atopic dermatitis and cancer ^[1] ^[3] .

HY-13425R

Deguelin (Standard) (-)-DeguelIN (Standard); (-)-cis-DeguelIN (Standard)	Structural Classification Flavonoids Leguminosae Isoflavanones Derris trifoliata Lour. Plants Source Classification	Akt Autophagy Apoptosis Reference Standards
Deguelin (Standard) is the analytical standard of Deguelin. This product is intended for research and analytical applications. Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.

Cat. No.	Product Name	Chemical Structure

HY-13685S1

Miltefosine-d4
Miltefosine-d₄ (HePC-d₄) is deuterium labeled Miltefosine. Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the *PI3K/Akt* activity ^[3] . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .

HY-N0479S

Licarin B-d4
Licarin B-d₄ is the deuterium labeled Licarin B (HY-N0479). Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway ^[3].

Cat. No.	Product Name		Classification

HY-13685

Miltefosine 10+ Cited Publications HePC; Hexadecyl phosphocholINe		Phospholipids
Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the *PI3K/Akt* activity ^[3] . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .

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PI3K/AKT-IN-1

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products