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  3. Licarin B

Licarin B (Synonyms: (-)-Licarin B)

Cat. No.: HY-N0479
Handling Instructions

Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway.

For research use only. We do not sell to patients.

Licarin B Chemical Structure

Licarin B Chemical Structure

CAS No. : 51020-87-2

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Description

Licarin B, a nitric oxide production inhibitor extracted from the component of the seeds of Myristica fragrans, improves insulin sensitivity via PPARγ and activation of GLUT4 in the IRS-1/PI3K/AKT pathway[1][2][3].

In Vitro

Licarin B (5 μM, 10 μM, 15 μM. 8 days) moderately increases TG accumulation during adipogenic differentiation and showed partial PPARg agonist activity in 3T3-L1 preadipocytes[2].

Cell Viability Assay[1]

Cell Line: 3T3-L1 cell.
Concentration: 1-500 μM.
Incubation Time: 48 h.
Result: Did not cause significant cell death up to 500 μM concentration.

Cell Viability Assay[1]

Cell Line: 3T3-L1 cell.
Concentration: 5 μM, 10 μM, 15 μM.
Incubation Time: 8 days (replaced every 2 days).
Result: LB at 15 μM concentration significantly promoted adipocyte differentiation and caused intracellular TG accumulation.
Molecular Weight

324.37

Formula

C₂₀H₂₀O₄

CAS No.

51020-87-2

SMILES

COC1=C(O[[email protected]@H](C2=CC=C3C(OCO3)=C2)[[email protected]@H]4C)C4=CC(/C=C/C)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Licarin B(-)-Licarin BPPARPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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