ALK/PI3K/AKT-IN-1
ALK/PI3K/AKT-IN-1 (Compound 45) inhibits the proliferation of cancer cell A549, H1975 and PC9 with an IC50 of 0.44, 0.83 and 1.51 μM. ALK/PI3K/AKT-IN-1 increases the expression of p21 and p27, inhibits the activity of CDK2 and p-Rb, arrests the cell cycle at G1 phase. ALK/PI3K/AKT-IN-1 inhibits the ALK/PI3K/AKT signaling pathway, promotes the depolarization of mitochondrial membrane potential, and inducing apoptosis in A549 cell. ALK/PI3K/AKT-IN-1 inhibits the formation and growth of A549 cell spheroids.
For research use only. We do not sell to patients.
- CAS No.: 3050831-84-7
- Formula: C25H20FN5O2S
- Molecular Weight:473.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 3050831-84-7
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Molecular Weight 473.52
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Formula C25H20FN5O2S
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SMILES
O=C(NC1=NC2=CC(C3=CC4=C(N=CN(CCC)C4=O)C=C3)=CC=C2S1)NC5=CC=C(F)C=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ALK/PI3K/AKT-IN-1 Related Classifications
HY-173007 Related Classifications
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