3050831-84-7
Chemical Structure
ALK/PI3K/AKT-IN-1
- No. CAS: 3050831-84-7
- Formula:C25H20FN5O2S
- Molecular Weight:473.52
InChIKey: UMJULCZTYVXICB-UHFFFAOYSA-N
SMILES: O=C(NC1=NC2=CC(C3=CC4=C(N=CN(CCC)C4=O)C=C3)=CC=C2S1)NC5=CC=C(F)C=C5
Biological Activity: ALK/PI3K/AKT-IN-1 (Compound 45) inhibits the proliferation of cancer cell A549, H1975 and PC9 with an IC50 of 0.44, 0.83 and 1.51 μM. ALK/PI3K/AKT-IN-1 increases the expression of p21 and p27, inhibits the activity of CDK2 and p-Rb, arrests the cell cycle at G1 phase. ALK/PI3K/AKT-IN-1 inhibits the ALK/PI3K/AKT signaling pathway, promotes the depolarization of mitochondrial membrane potential, and inducing apoptosis in A549 cell. ALK/PI3K/AKT-IN-1 inhibits the formation and growth of A549 cell spheroids[1].
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ALK/PI3K/AKT-IN-1 | ALK/PI3K/AKT-IN-1 (Compound 45) inhibits the proliferation of cancer cell A549, H1975 and PC9 with an IC50 of 0.44, 0.83 and 1.51 μM. ALK/PI3K/AKT-IN-1 increases the expression of p21 and p27, inhibits the activity of CDK2 and p-Rb, arrests the cell cycle at G1 phase. ALK/PI3K/AKT-IN-1 inhibits the ALK/PI3K/AKT signaling pathway, promotes the depolarization of mitochondrial membrane potential, and inducing apoptosis in A549 cell. ALK/PI3K/AKT-IN-1 inhibits the formation and growth of A549 cell spheroids. | |||||||||||||||||||||
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Keywords
