2. PI3K/Akt/mTOR Apoptosis
  3. Akt Apoptosis
  4. AKT-IN-21

AKT-IN-21 (compound C36) is a potent AKT inhibitor with broad-spectrum cytotoxicity and anticancer activity. AKT-IN-21 also blocks the cell cycle and induces apoptosis of cancer cells by down-regulating the PI3K/AKT pathway.

For research use only. We do not sell to patients.

AKT-IN-21 Chemical Structure

AKT-IN-21 Chemical Structure

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AKT-IN-21 Related Antibodies

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Description

AKT-IN-21 (compound C36) is a potent AKT inhibitor with broad-spectrum cytotoxicity and anticancer activity. AKT-IN-21 also blocks the cell cycle and induces apoptosis of cancer cells by down-regulating the PI3K/AKT pathway[1].

In Vitro

AKT-IN-21 shows anti-proliferation inhibitory activity and cytotoxcity among serval cancer cells, with IC50s of 2.33 μM (LNCaP), 2.38 μM (K562), 1.98 μM (HepG2), 3.95 μM (LX-2), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AKT-IN-21 Related Antibodies
Molecular Weight

438.56

Formula

C26H34N2O4
SMILES

COC1=C(C(/C=C/C2=CN=CC=C2)=O)C(O)=C(C/C=C(C)/C)C(OCCN(CC)CC)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AKT-IN-21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AKT-IN-21AktApoptosisPKBProtein kinase BantitumorCytotoxicityPI3K/AKT pathwayPrenylated chalcone derivativesInhibitorinhibitorinhibit

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AKT-IN-21
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HY-161144
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