2. Metabolic Enzyme/Protease NF-κB Apoptosis
  3. MALT1 Apoptosis
  4. MALT1-IN-13

MALT1-IN-13 (compound 10m) is inhibitor for mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), which to binds MALT1 protease covalently and irreversibly, inhibits MALT1 with the IC50 of 1.7 μM. MALT1-IN-13 inhibits proliferation against ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1. MALT1-IN-13 regulates mTOR and PI3K-Akt pathways.

For research use only. We do not sell to patients.

MALT1-IN-13

MALT1-IN-13 Chemical Structure

CAS No. : 3032823-58-5

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

MALT1-IN-13 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MALT1-IN-13 (compound 10m) is inhibitor for mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), which to binds MALT1 protease covalently and irreversibly, inhibits MALT1 with the IC50 of 1.7 μM. MALT1-IN-13 inhibits proliferation against ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1. MALT1-IN-13 regulates mTOR and PI3K-Akt pathways[1].

IC50 & Target

IC50: 1.7 μM (MALT1)
Cellular Effect
Cell Line Type Value Description References
HBL1 GI50
0.69 μM
Compound: 10m
Synergistic antitumor activity against human HBL1 cells assessed as cell growth inhibition incubated for 72 hrs in presence of rapamycin by Cell Titer Glo assay
Synergistic antitumor activity against human HBL1 cells assessed as cell growth inhibition incubated for 72 hrs in presence of rapamycin by Cell Titer Glo assay
[PMID: 38349664]
HBL1 GI50
1.5 μM
Compound: 10m
Antiproliferative activity against human HBL1 cells assessed as cell growth inhibition incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human HBL1 cells assessed as cell growth inhibition incubated for 72 hrs by Cell Titer Glo assay
[PMID: 38349664]
OCI-Ly1 GI50
> 25 μM
Compound: 10m
Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition incubated for 72 hrs by Cell Titer Glo assay
[PMID: 38349664]
TMD8 GI50
0.7 μM
Compound: 10m
Antiproliferative activity against human TMD8 cells assessed as cell growth inhibition incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human TMD8 cells assessed as cell growth inhibition incubated for 72 hrs by Cell Titer Glo assay
[PMID: 38349664]
In Vitro

MALT1-IN-13 (0-10 μM) induces apoptosis in HBL1 cells, inhibits proliferation against ABC-DLBCL HBL1, TMD8 and GCB-DLBCL OCI-LY1 cells with GI50 of 1.5, 0.7 and >25 μM, respecticely[1].
MALT1-IN-13 (0-10 μM) downregulates expressions of MALT1 and NF-kB pathway, upregulates the mTOR and PI3K-Akt pathway, exhibits an antitumor effect in the HBL1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MALT1-IN-13 Related Antibodies

Apoptosis Analysis[1]

Cell Line: ABC-DLBCL HBL1
Concentration: 0-10 μM
Incubation Time: 24 h
Result: Induced over 70% apoptosis in HBL1 cells with concentration of 5 μM.

Cell Proliferation Assay[1]

Cell Line: ABC-DLBCL HBL1, ABC-DLBCL TMD8 and GCB-DLBCL OCI-LY1
Concentration: 100 μM
Incubation Time: 72 h
Result: Inhibits proliferations of ABC-DLBCL HBL1, TMD8 and GCB-DLBCL OCI-LY1.

Apoptosis Analysis[1]

Cell Line: ABC-DLBCL HBL1 and ABC-DLBCL TMD8
Concentration: 0-10 μM
Incubation Time: 24 h
Result: Increased levels of cleaved PARP1 and caspase3. Decreased levels of IkBα and phosphorylated IkBα.
In Vivo

MALT1-IN-13 (25 mg/kg, i.p. for 12-14 days) exhibits an antitumor activity specific for MALT1 protease and suppresses the tumor growth in HBL1/TMD8 xenografted NCG mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HBL1/TMD8/OCI-LY1 xenografted NCG mice[1]
Dosage: 25 mg/kg
Administration: i.p., 12 days for HBL1 bearing NCG mice, 14 days for TMD8 bearing mice, 19 days for OCI-LY1 bearing mice
Result: Suppressed the HBL1 tumor growth and decreased the tumor weight with TGI of 55.9%.
Suppressed the TMD8 tumor growth and decreased the tumor weight with TGI of 69.9%.
Molecular Weight

524.84

Formula

C20H15BrClN3O3S2
CAS No.
SMILES

O=C1C(S2)=C(N=C(N1C3=CC(OC)=CC=C3OC)CBr)N(C4=CC=CC(Cl)=C4)C2=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

MALT1-IN-13 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MALT1-IN-133032823-58-5MALT1Apoptosismucosa associated lymphoid tissue lymphoma translocation gene 1mucosa-associated lymphoid tissue lymphoma translocation proteinrapamycinactivated B cell-like diffuse large B cell lymphomaABC-DLBCLgerminal center B cell-like diffuse large B cell lymphomaGCB-DLBCLInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
MALT1-IN-13
Cat. No.:
HY-162268
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.