2. Metabolic Enzyme/Protease NF-κB Apoptosis
  3. MALT1 Apoptosis
  4. MALT1-IN-13

MALT1-IN-13 (compound 10m) is inhibitor for mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), which to binds MALT1 protease covalently and irreversibly, inhibits MALT1 with the IC50 of 1.7 μM. MALT1-IN-13 inhibits proliferation against ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1. MALT1-IN-13 regulates mTOR and PI3K-Akt pathways.

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MALT1-IN-13 Chemical Structure

MALT1-IN-13 Chemical Structure

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MALT1-IN-13 Related Antibodies

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Description

MALT1-IN-13 (compound 10m) is inhibitor for mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), which to binds MALT1 protease covalently and irreversibly, inhibits MALT1 with the IC50 of 1.7 μM. MALT1-IN-13 inhibits proliferation against ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1. MALT1-IN-13 regulates mTOR and PI3K-Akt pathways[1].

IC50 & Target

IC50: 1.7 μM (MALT1)
In Vitro

MALT1-IN-13 (0-10 μM) induces apoptosis in HBL1 cells, inhibits proliferation against ABC-DLBCL HBL1, TMD8 and GCB-DLBCL OCI-LY1 cells with GI50 of 1.5, 0.7 and >25 μM, respecticely[1].
MALT1-IN-13 (0-10 μM) downregulates expressions of MALT1 and NF-kB pathway, upregulates the mTOR and PI3K-Akt pathway, exhibits an antitumor effect in the HBL1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MALT1-IN-13 Related Antibodies

Apoptosis Analysis[1]

Cell Line: ABC-DLBCL HBL1
Concentration: 0-10 μM
Incubation Time: 24 h
Result: Induced over 70% apoptosis in HBL1 cells with concentration of 5 μM.

Cell Proliferation Assay[1]

Cell Line: ABC-DLBCL HBL1, ABC-DLBCL TMD8 and GCB-DLBCL OCI-LY1
Concentration: 100 μM
Incubation Time: 72 h
Result: Inhibits proliferations of ABC-DLBCL HBL1, TMD8 and GCB-DLBCL OCI-LY1.

Apoptosis Analysis[1]

Cell Line: ABC-DLBCL HBL1 and ABC-DLBCL TMD8
Concentration: 0-10 μM
Incubation Time: 24 h
Result: Increased levels of cleaved PARP1 and caspase3. Decreased levels of IkBα and phosphorylated IkBα.
In Vivo

MALT1-IN-13 (25 mg/kg, i.p. for 12-14 days) exhibits an antitumor activity specific for MALT1 protease and suppresses the tumor growth in HBL1/TMD8 xenografted NCG mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HBL1/TMD8/OCI-LY1 xenografted NCG mice[1]
Dosage: 25 mg/kg
Administration: i.p., 12 days for HBL1 bearing NCG mice, 14 days for TMD8 bearing mice, 19 days for OCI-LY1 bearing mice
Result: Suppressed the HBL1 tumor growth and decreased the tumor weight with TGI of 55.9%.
Suppressed the TMD8 tumor growth and decreased the tumor weight with TGI of 69.9%.
Molecular Weight

524.84

Formula

C20H15BrClN3O3S2
SMILES

O=C1C(S2)=C(N=C(N1C3=CC(OC)=CC=C3OC)CBr)N(C4=CC=CC(Cl)=C4)C2=S
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MALT1-IN-13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MALT1-IN-13MALT1Apoptosismucosa associated lymphoid tissue lymphoma translocation gene 1mucosa-associated lymphoid tissue lymphoma translocation proteinrapamycinactivated B cell-like diffuse large B cell lymphomaABC-DLBCLgerminal center B cell-like diffuse large B cell lymphomaGCB-DLBCLInhibitorinhibitorinhibit

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