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Results for "

Rifampicin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Acyltransferase (1) Antibiotic (14) Bacterial (22) Carbonic Anhydrase (1) Cytochrome P450 (4) DNA/RNA Synthesis (2) Drug Derivative (2) Drug Intermediate (5) Drug Metabolite (3) Endogenous Metabolite (1) Environmental Pollutants (1) Factor Xa (1) Fungal (3) Influenza Virus (6) Isotope-Labeled Compounds (3) Orthopoxvirus (3) Pregnane X Receptor (PXR) (1) Reference Standards (5) Serotonin Transporter (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Infection (28) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (1)

By Targets:

5-HT Receptor (1)

Acyltransferase (1)

Antibiotic (14)

Bacterial (22)

Carbonic Anhydrase (1)

Cytochrome P450 (4)

DNA/RNA Synthesis (2)

Drug Derivative (2)

Drug Intermediate (5)

Drug Metabolite (3)

Endogenous Metabolite (1)

Environmental Pollutants (1)

Factor Xa (1)

Fungal (3)

Influenza Virus (6)

Isotope-Labeled Compounds (3)

Orthopoxvirus (3)

Pregnane X Receptor (PXR) (1)

Reference Standards (5)

Serotonin Transporter (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (2)

Infection (28)

Inflammation/Immunology (2)

Metabolic Disease (2)

Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0272

*Rifampicin* Maximum Cited Publications 45 Publications Verification Rifampin; Rifamycin AMP	Bacterial Influenza Virus Antibiotic Orthopoxvirus	Infection Cancer
Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity.

HY-B1864A

Kasugamycin hydrochloride 1 Publications Verification Ksg hydrochloride	Environmental Pollutants Antibiotic Bacterial	Infection
Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. Kasugamycin hydrochloride hydrate mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate increases the sensitivity of mycobacteria to Rifampicin (HY-B0272) in vitro and in mouse infection models .

HY-B0272R

Rifampicin (Standard) Rifampin (Standard); Rifamycin AMP (Standard)	Reference Standards Bacterial Influenza Virus Antibiotic Orthopoxvirus	Infection Cancer
Rifampicin (Standard) is the analytical standard of Rifampicin. This product is intended for research and analytical applications. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity.

HY-B1324

Oxiconazole nitrate 2 Publications Verification Ro 13-8996	Fungal Cytochrome P450 Antibiotic	Infection Cancer
Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .

HY-B1864B

Kasugamycin hydrochloride hydrate 1 Publications Verification Ksg hydrochloride hydrate	Antibiotic Bacterial	Infection
Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. Kasugamycin hydrochloride hydrate mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate increases the sensitivity of mycobacteria to Rifampicin (HY-B0272) in vitro and in mouse infection models .

HY-119124

Edoxaban M4 D21-2393	Factor Xa	Cardiovascular Disease Inflammation/Immunology
Edoxaban M4 (D21-2393) is an orally active and selective Factor Xa inhibitor with a human Factor Xa IC₅₀ of 1.8 nM. Edoxaban M4 exhibits anticoagulant activity via Factor Xa inhibition. Edoxaban M4 can be used for the research of non-valvular atrial fibrillation, venous thromboembolisms, pulmonary embolism .

HY-129043

3-Formyl rifamycin	Drug Metabolite	Infection
3-Formyl rifamycin is an acid degradation product of the broad-spectrum antibiotic Rifampicin (HY-B0272). 3-Formyl rifamycin forms via acid hydrolysis of Rifampicin in an acidic environment .

HY-B0272S2

Rifampicin-d4 Rifampin-d₄; Rifamycin AMP-d₄	Bacterial Influenza Virus Antibiotic	Infection
Rifampicin-d₄ is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.

HY-B0272S1

Rifampicin-d8 Rifampin-d₈; Rifamycin AMP-d₈	Bacterial Influenza Virus Antibiotic	Infection
Rifampicin-d8 (Rifampin-d8) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.

HY-125587

25-Desacetyl rifampicin DesacetylRifampicin	Drug Metabolite	Infection
25-Desacetyl rifampicin (Desacetylrifampicin) is a metabolite of Rifampin (HY-B0272) via β-esterase. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens .

HY-B0272S

Rifampicin-d3 Rifampin-d₃; Rifamycin AMP-d₃	Bacterial Influenza Virus Antibiotic	Infection
Rifampicin-d₃ is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities .

HY-B0272S3

Rifampicin-d11 Rifampin-d₁₁; Rifamycin AMP-d₁₁	Isotope-Labeled Compounds Antibiotic Bacterial Influenza Virus Orthopoxvirus	Others
Rifampicin-d₁₁ (Rifampin-d₁₁; Rifamycin AMP-d₁₁) is the deuterium labeled Rifampicin (HY-B0272) . Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity .

HY-B1324A

Oxiconazole Ro 13-8996 free base	Fungal Cytochrome P450 Antibiotic	Infection Cancer
Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .

HY-153696

MRL-436	DNA/RNA Synthesis Bacterial	Infection
MRL-436 is a RNA polymerase inhibitor with antibacterial activity. MRL-436 exerts its antibacterial activity dependent on residue 622 of the RNA polymerase β' subunit and the RNAP ω subunit. MRL-436 inhibits Rifampicin (HY-B0272)-resistant RNA polymerase derivatives and exhibits antibacterial activity against Rifampicin-resistant strains .

HY-W738288

Rifamdin	Bacterial Drug Derivative DNA/RNA Synthesis	Infection
Rifamdin is a derivative of Rifampicin (HY-B0272). Rifamdin is an anti-tuberculosis agent. Rifamdin exerts its antibacterial effect by inhibiting the synthesis of bacterial RNA .

HY-172456

JSF-4898	Bacterial	Infection
JSF-4898 is an orally active inhibitor of the MenG enzyme in Mycobacterium tuberculosis. JSF-4898 has MIC of 0.78 μM against Mycobacterium tuberculosis H37Rv. JSF-4898 can enhance the efficacy of Rifampicin (HY-B0272) in a subacute model of Mycobacterium tuberculosis infection in mice .

HY-W009681

1-(2-Methoxyphenyl)piperazine hydrochloride	5-HT Receptor Serotonin Transporter Drug Intermediate	Infection Neurological Disease
1-(2-Methoxyphenyl)piperazine hydrochloride is a key agent intermediate of antipsychotics with high affinity to the serotonin receptors and 5-HT, which can be used to synthesize the intestinal worm-repellent agents Piperazine phosphate (HY-B0912C) and Piperazine citrate (HY-17599), as well as Fluphenazine (HY-119980), dihydrochloride, Rifampicin (HY-B0272) .

HY-175264

MI891	Pregnane X Receptor (PXR) Cytochrome P450	Metabolic Disease
MI891 is a highly selective PXR antagonist (IC₅₀ = 3.76 μM, K_d = 1.7 μM) and inverse agonist (IC₅₀ = 6.1 μM). MI891 selectively disrupts the interaction between PXR and its coactivator SRC1. MI891 effectively inhibits Rifampicin (HY-B0272)-induced PXR activation. MI891 is useful for the study of metabolic diseases and other diseases .

HY-P5704

K11	Bacterial	Infection
K11 is an antimicrobial peptide. K11 is active against MDR/XDR K. pneumoniae isolates (MIC: 8-512 μg/mL), and inhibits bacterial biofilm formation. K11 can act synergistically with antibiotics (Chloramphenicol (HY-B0239), Meropenem (HY-13678), Rifampicin (HY-B0272), etc.) against drug-resistant K. pneumoniae. K11 has high thermal and wide pH stability .

HY-179127

Carbonic anhydrase-IN-36	Carbonic Anhydrase Bacterial	Infection
Carbonic anhydrase-IN-36 (Compound 5p) is a MtCA 3 inhibitor with a K_i of 0.07 µM against MtCA 3. Carbonic anhydrase-IN-36 inhibits the β-class enzyme MtCA 3. Carbonic anhydrase-IN-36 demonstrates potent antimycobacterial activity, with an MIC of 8 µg/mL against Mtb. Carbonic anhydrase-IN-36 retains activity against Rifampicin (HY-B0272)-resistant M. tuberculosis .

HY-125587S

*25-Desacetyl Rifampicin-d3*	Isotope-Labeled Compounds	Others
25-Desacetyl Rifampicin-d₃ is the deuterium labeled 25-Desacetyl Rifampicin .

HY-162094

CMX410	Acyltransferase Bacterial	Infection
CMX410 is an orally active and selective Mycobacterium tuberculosis Pks13 acyltransferase domain inhibitor and anti-bacterial agent. CMX410 reacts with the catalytic serine of the Pks13-AT domain to form a stable β-lactam ring, disables the enzyme’s active site, reduces trehalose monomycolate and trehalose dimycolate levels, triggers cell lysis, and reduces intracellular bacterial burden. CMX410 can be used for the research of tuberculosis .

HY-125587S1

*25-Desacetyl rifampicin-d4* DesacetylRifampicin-d₄	Isotope-Labeled Compounds	Others
25-Desacetyl rifampicin-d4 (Desacetylrifampicin-d4) is deuterated-labeled 25-Desacetyl rifampicin .

HY-N3241

Mucrolidin	Bacterial	Infection
Mucrolidin is an eudesmane-type sesquiterpenoid isolated from aerial parts of homalomena occulta. Mucrolidin exhibits weak antibacterial activities when it compares to Rifampicin (HY-B0272) .

HY-B1324R

Oxiconazole nitrate (Standard) Ro 13-8996 (Standard)	Reference Standards Fungal Cytochrome P450 Antibiotic	Infection Cancer
Oxiconazole nitrate (Standard) is the analytical standard of Oxiconazole nitrate. This product is intended for research and analytical applications. Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .

HY-129043R

3-Formyl rifamycin (Standard)	Reference Standards Drug Metabolite	Infection
3-Formyl rifamycin (Standard) is the analytical standard of 3-Formyl rifamycin (HY-129043). This product is intended for research and analytical applications. 3-Formyl rifamycin is an acid degradation product of the broad-spectrum antibiotic Rifampicin (HY-B0272). 3-Formyl rifamycin forms via acid hydrolysis of Rifampicin in an acidic environment .

HY-158241

GmhA-IN-1	Bacterial	Infection
GmhA-IN-1 (compound 17) is an inhibitor of GmhA with an IC₅₀ value of 2.4 nM. GmhA-IN-1 enhances the activity of erythromycin and rifampicin on wild-type E. coli .

HY-P5680

SpHistin	Bacterial	Inflammation/Immunology
SpHistin is an antimicrobial peptide (AMP). SpHistin can bind to LPS (HY-D1056) and permeabilize the bacterial membrane. SpHistin combined with Rifampicin (HY-B0272) and Azithromycin (HY-17506) promotes the intracellular uptake of the antibiotics and subsequently enhances the bactericidal activity of both agents against P. aeruginosa .

HY-161395

IDD-8E	Bacterial	Infection
IDD-8E is an effective anti-pseudomonal agent (MIC =4.4 µM ) with no cytotoxicity. IDD-8E shows significant pseudomonal killing and disruption of pseudomonal biofilm. IDD-8E binds to the ATP-binding pocket of WaaP and also inhibits other ESKAPE pathogens.

HY-B1864C

Kasugamycin sulfate Ksg sulfate	Antibiotic Bacterial	Infection
Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. Kasugamycin hydrochloride hydrate mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate increases the sensitivity of mycobacteria to Rifampicin (HY-B0272) in vitro and in mouse infection models .

HY-B1864AR

Kasugamycin hydrochloride (Standard) Ksg hydrochloride (Standard)	Reference Standards Antibiotic Bacterial	Infection
Kasugamycin (Ksg) hydrochloride (Standard) is the analytical standard of Kasugamycin hydrochloride (HY-B1864A). This product is intended for research and analytical applications. Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. Kasugamycin hydrochloride hydrate mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate increases the sensitivity of mycobacteria to Rifampicin (HY-B0272) in vitro and in mouse infection models .

HY-B1864BR

Kasugamycin hydrochloride hydrate (Standard) Ksg hydrochloride hydrate (Standard)	Reference Standards Antibiotic Bacterial	Infection
Kasugamycin (Ksg) hydrochloride hydrate (Standard) is the analytical standard of Kasugamycin hydrochloride hydrate (HY-B1864B). This product is intended for research and analytical applications. Kasugamycin (Ksg) hydrochloride hydrate is an antibiotic that binds to 30s and 70s ribosomes but not to the 50s subunit, and has anti-infective activity. Kasugamycin hydrochloride hydrate mimics mRNA nucleotides, disrupts tRNA binding and inhibits canonical translation initiation. Kasugamycin hydrochloride hydrate increases the sensitivity of mycobacteria to Rifampicin (HY-B0272) in vitro and in mouse infection models .

HY-W587664

Rifampicin impurity 4	Drug Intermediate	Others
Rifampicin impurity 4 is an impurity of Rifampicin.

HY-W738398

Rifampicin impurity 1	Drug Intermediate	Others
Rifampicin impurity 1 is an impurity of Rifampicin.

HY-Z8399

Rifampicin impurity 3	Drug Intermediate	Others
Rifampicin impurity 3 is an impurity of Rifampicin.

HY-175016

NADH-IN-3	Endogenous Metabolite	Infection Metabolic Disease
NADH-IN-3 (Compound C4-1) is a NADH inhibitor with a MIC of 4 μg/mL (13.042 μM) for type II NADH dehydrogenase of Mycobacterium tuberculosis (Mtb). NADH-IN-3 significantly interrupts ATP synthesis, shows potent inhibitory effects against mono (Rifampicin (HY-B0272) and Isoniazid (HY-B0329)) and multi drug-resistant (Mtb) strains and an anti-bactericidal activity against HepG2 cells with low cytotoxicity (SI: 16.52) .

HY-B1922

Rifampicin impurity 2 Rifaldazinequinone	Drug Intermediate	Others
Rifampicin impurity 2 (Rifaldazinequinone) is an impurity of Rifampicin.

HY-19159

CGP-43371	Drug Derivative	Cardiovascular Disease
CGP-43371, a Rifampicin (HY-B0272) derivative, is an orally active hypolipidemic agent. CGP-43371 has hypolipidemic and anti-atherosclerotic activities .

HY-180399

Antibacterial agent 323	Bacterial	Infection
Antibacterial agent 323 is an antifbacterial agent with weak activity. Antibacterial agent 323 can be used for the research of bacterial nfection, such as Acinetobacter baumannii strains .

Cat. No.	Product Name

HY-L142

Anti-tuberculosis Compound Library	151 compounds
Tuberculosis (TB), usually caused by bacteria (Mycobacterium tuberculosis), is an infectious disease that mainly affects the lungs. According to the statistics of the World Health Organization (WHO), 10 million people suffer from tuberculosis every year, and 1.5 million people die of tuberculosis every year, which makes tuberculosis the number one killer of infectious diseases. Tuberculosis can be cured through the standard 6-month course of treatment of four kinds of antibiotics. Common drugs include rifampicin and isoniazid. In some cases, TB bacteria do not respond to standard drugs, that is, patients with drug-resistant tuberculosis. The treatment of drug-resistant tuberculosis takes longer and is more complex. In the face of the resurgence of tuberculosis in the world and the rapid emergence of multi drug resistant tuberculosis, it is very important to develop new anti-tuberculosis drugs or new clinical treatment schemes for existing anti mycobacterium drugs. MCE supplies a unique collection of 151 compounds with clear anti-tuberculosis activity. MCE Anti-tuberculosis Compound Library is a useful tool for anti-tuberculosis related research and anti-tuberculosis drug development

Anti-tuberculosis Compound Library

151 compounds

Tuberculosis (TB), usually caused by bacteria (Mycobacterium tuberculosis), is an infectious disease that mainly affects the lungs. According to the statistics of the World Health Organization (WHO), 10 million people suffer from tuberculosis every year, and 1.5 million people die of tuberculosis every year, which makes tuberculosis the number one killer of infectious diseases.

Tuberculosis can be cured through the standard 6-month course of treatment of four kinds of antibiotics. Common drugs include rifampicin and isoniazid. In some cases, TB bacteria do not respond to standard drugs, that is, patients with drug-resistant tuberculosis. The treatment of drug-resistant tuberculosis takes longer and is more complex. In the face of the resurgence of tuberculosis in the world and the rapid emergence of multi drug resistant tuberculosis, it is very important to develop new anti-tuberculosis drugs or new clinical treatment schemes for existing anti mycobacterium drugs.

MCE supplies a unique collection of 151 compounds with clear anti-tuberculosis activity. MCE Anti-tuberculosis Compound Library is a useful tool for anti-tuberculosis related research and anti-tuberculosis drug development

Cat. No.	Product Name	Target	Research Area