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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
TLR4/NF-κB/MAPK signaling
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "TLR4/NF-κB/MAPK signaling" in MCE Product Catalog:
6
6 Publications Verification
Target:
Research Areas:
IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development .
2
2 Cited Publications
Synonyms: β-FNA hydrochloride
Research Areas:
β-Funaltrexamine (β-FNA) hydrochloride is a blood-brain barrier-permeable, selective and irreversible μ-opioid receptor antagonist with immunomodulatory, anti-inflammatory and neuroprotective activities. β-Funaltrexamine hydrochloride inhibits p38 MAPK and TLR4 signaling by blocking μ-opioid receptors, and reduces the transcriptional activities of NF-κB, AP-1, CREB and Stat. Furthermore, β-Funaltrexamine hydrochloride inhibits iNOS activation and pro-inflammatory microglial polarization, converting microglia to an anti-inflammatory phenotype, thereby downregulating neuroinflammation and ameliorating neuronal degeneration. β-Funaltrexamine hydrochloride is widely applicable to research related to stroke, cerebral ischemia/reperfusion injury and neurodegenerative diseases .
1
1 Cited Publications
Cat. No.: HY-N2830
CAS No.: 21499-24-1
1
1 Cited Publications
Cat. No.: HY-P5524A
Synonyms: Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid hydrochloride; γ-D-glutamyl-meso-diaminopimelic acid hydrochloride
Research Areas:
Cat. No.: HY-N0392
CAS No.: 882664-74-6
Cat. No.: HY-W097625
CAS No.: 26964-24-9
Cat. No.: HY-NP192
Cat. No.: HY-P5524
CAS No.: 1269619-57-9
Synonyms: Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid; γ-D-glutamyl-meso-diaminopimelic acid
Research Areas:
Cat. No.: HY-129440R
CAS No.: 68573-24-0
Cat. No.: HY-N0392R
CAS No.: 882664-74-6
Cat. No.: HY-N17383
CAS No.: 2283387-37-9
Cat. No.: HY-160938
CAS No.: 72782-05-9
Synonyms: β-FNA
Research Areas:
β-Funaltrexamine (β-FNA) is a blood-brain barrier-permeable, selective and irreversible μ-opioid receptor antagonist with immunomodulatory, anti-inflammatory and neuroprotective activities. β-Funaltrexamine inhibits p38 MAPK and TLR4 signaling by blocking μ-opioid receptors, and reduces the transcriptional activities of NF-κB, AP-1, CREB and Stat. Furthermore, β-Funaltrexamine inhibits iNOS activation and pro-inflammatory microglial polarization, converting microglia to an anti-inflammatory phenotype, thereby downregulating neuroinflammation and ameliorating neuronal degeneration. β-Funaltrexamine is widely applicable to research related to stroke, cerebral ischemia/reperfusion injury and neurodegenerative diseases .
Cat. No.: HY-N9541
CAS No.: 1399690-75-5
Category:
Target:
Cat. No.: HY-W097625R
CAS No.: 26964-24-9
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
