2. Immunology/Inflammation NF-κB MAPK/ERK Pathway Metabolic Enzyme/Protease Others Cell Cycle/DNA Damage
  3. NF-κB p38 MAPK MyD88 Toll-like Receptor (TLR) Reference Standards Heme Oxygenase (HO) PERK
  4. 6-Methoxyflavone (Standard)

6-Methoxyflavone (Standard) is the analytical standard of 6-Methoxyflavone (HY-W097625). This product is intended for research and analytical applications. 6-Methoxyflavone is an orally active methoxyflavone. 6-Methoxyflavone suppresses neuroinflammation in microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. 6-Methoxyflavone induces S-phase arrest through the CCNA2/CDK2/p21CIP1 signaling pathway and activates the PERK/EIF2a/ATF4/CHOP pathway in HeLa cells. 6-Methoxyflavone acts as a Flumazenil (HY-B0009)-insensitive positive allosteric modulator at human recombinant α1β2γ2L and α2β2γ2L GABAα receptors. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. 6-Methoxyflavone partially restores chronic ethanol-induced behavioral deficits in mice. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. 6-Methoxyflavone can be used for the study of cancer, inflammation and neurological diseases.

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6-Methoxyflavone (Standard)

6-Methoxyflavone (Standard) Chemical Structure

CAS No. : 26964-24-9

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Information

6-Methoxyflavone (Standard) is the analytical standard of 6-Methoxyflavone (HY-W097625). This product is intended for research and analytical applications. 6-Methoxyflavone is an orally active methoxyflavone. 6-Methoxyflavone suppresses neuroinflammation in microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. 6-Methoxyflavone induces S-phase arrest through the CCNA2/CDK2/p21CIP1 signaling pathway and activates the PERK/EIF2a/ATF4/CHOP pathway in HeLa cells. 6-Methoxyflavone acts as a Flumazenil (HY-B0009)-insensitive positive allosteric modulator at human recombinant α1β2γ2L and α2β2γ2L GABAα receptors. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. 6-Methoxyflavone partially restores chronic ethanol-induced behavioral deficits in mice. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. 6-Methoxyflavone can be used for the study of cancer, inflammation and neurological diseases.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

252.27

Formula

C16H12O3
CAS No.
SMILES

O=C1C=C(C2=CC=CC=C2)OC3=CC=C(OC)C=C13
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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6-Methoxyflavone (Standard) Related Classifications

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Keywords:

6-Methoxyflavone (Standard)26964-24-9NF-κBp38 MAPKMyD88Toll-like Receptor (TLR)Reference StandardsHeme Oxygenase (HO)PERKNuclear factor-κBNuclear factor-kappaBHeme OxygenaseProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseethanol cognition6-methoxyflavonedopaminenoradrenalinehippocampusfrontal cortexcancerinflammationneurological deseasesInhibitorinhibitorinhibit

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