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Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers.
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Eftozanermin alfa (ABBV-621) is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa induces apoptosis in tumor cells by activation of death receptors 4/5. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies .
Lexatumumab (HGS-ETR 2) is a human agonistic TRAIL receptor 2 (TRAIL-R2, DR5, APO-2) IgG4κ type monoclonal antibody. Lexatumumab induces apoptosis in malignant mesothelioma. Lexatumumab can be used for malignant pleural mesothelioma (MPM) research .
Py-MAA-Val-Cit-PAB-MMAE is a drug-Linker conjugates for ADC, which is composed of MMAE (HY-15162) and Py-MAA-Val-Cit-PAB linked. Py-MAA-Val-Cit-PAB-MMAE can be used to synthesize Zapadcine-3a, which targeting TRAILR2. Zapadcine-3a has broad-spectrum anti-tumor activity, and can specifically kill TRAILR2-positive tumors .
Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer .
Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers.
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Eftozanermin alfa (ABBV-621) is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa induces apoptosis in tumor cells by activation of death receptors 4/5. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies .
Lexatumumab (HGS-ETR 2) is a human agonistic TRAIL receptor 2 (TRAIL-R2, DR5, APO-2) IgG4κ type monoclonal antibody. Lexatumumab induces apoptosis in malignant mesothelioma. Lexatumumab can be used for malignant pleural mesothelioma (MPM) research .
Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer .
Mapatumumab (HGS-ETR1) is a fully human IgG1 agonistic monoclonal antibody that targets tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1). Mapatumumab can be used for the research of cancer .
TRAIL R1/TNFRSF10A protein is a receptor for TNFSF10/TRAIL, which recruits caspase-8 through FADD to initiate cell apoptosis and form a death-inducing signaling complex (DISC). It activates NF-kappa-B and interacts with TRADD and RIPK1 in the monomeric state. TRAIL R1/TNFRSF10A Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TRAIL R1/TNFRSF10A protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of TRAIL R1/TNFRSF10A Protein, Human (Biotinylated, HEK293, His-Avi) is 206 a.a., with molecular weight of 25-30 kDa.
TRAIL R1/TNFRSF10A Protein, a receptor for TNFSF10/TRAIL, initiates apoptosis by recruiting caspase-8 via FADD, forming the death-inducing signaling complex (DISC). It activates NF-kappa-B and interacts with TRADD and RIPK1 in its monomeric state. TRAIL R1/TNFRSF10A forms homooligomers and heterooligomers with TNFRSF10B, interacting with the TNFSF10 homotrimer. It also interacts with ARAP1 and ZDHHC3, highlighting its role in complex signaling networks. In the absence of stimulation, it interacts with BIRC2, DDX3X, and GSK3B, and stimulation enhances these interactions, accompanied by cleavage of DDX3X and BIRC2, emphasizing its multifaceted role in apoptotic and signaling pathways. TRAIL R1/TNFRSF10A Protein, Human (HEK293, His-Avi) is the recombinant human-derived TRAIL R1/TNFRSF10A protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of TRAIL R1/TNFRSF10A Protein, Human (HEK293, His-Avi) is 206 a.a., with molecular weight of 25-30 kDa.
TRAIL R2/TNFRSF10B Protein serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. Upon ligand binding, the adapter molecule FADD recruits caspase-8 to the activated receptor, forming the death-inducing signaling complex (DISC). This activation leads to a cascade of caspases, mediating apoptosis. TRAIL R2/TNFRSF10B lacks conserved residue(s) crucial for feature annotation propagation. TRAIL R2/TNFRSF10B Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293, with C-His labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Cynomolgus (HEK293, His) is 155 a.a., with molecular weight of 25-35 kDa.
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human (HEK293, hFc) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Human (HEK293, hFc) is 127 a.a., with molecular weight of ~41 kDa.
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-His labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Human (Biotinylated, HEK293, His) is 127 a.a., with molecular weight of ~15.8 kDa.
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by E. coli , with tag free. The total length of TRAIL R2/TNFRSF10B Protein, Human is 132 a.a., with molecular weight of ~14.8 kDa.
TRAILR4/TNFRSF10D Protein, a receptor for TRAIL, lacks the ability to induce apoptosis due to a truncated death domain. Paradoxically, it not only fails to induce apoptosis but also protects against TRAIL-mediated apoptosis. Conflicting reports exist about its role in activating the NF-kappa-B pathway. The dual nature of TRAILR4/TNFRSF10D in interacting with TRAIL, both as a receptor and a protective factor, highlights the complexity of its regulatory functions in cellular responses to TRAIL signaling. TRAILR4/TNFRSF10D Protein, Human (HEK293, His) is the recombinant human-derived TRAILR4/TNFRSF10D protein, expressed by HEK293, with C-His labeled tag. The total length of TRAILR4/TNFRSF10D Protein, Human (HEK293, His) is 156 a.a., with molecular weight of 30-40 kDa.
TRAILR4/TNFRSF10D protein is a receptor for TRAIL and lacks the ability to induce apoptosis due to the truncated death domain. Paradoxically, not only does it fail to induce apoptosis, but it also prevents TRAIL-mediated apoptosis. TRAILR4/TNFRSF10D Protein, Human (HEK293, Fc) is the recombinant human-derived TRAILR4/TNFRSF10D protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TRAILR4/TNFRSF10D Protein, Human (HEK293, Fc) is 156 a.a., with molecular weight of 50-70 kDa.
TRAILR4/TNFRSF10D Protein , a receptor for TRAIL. Paradoxically, it not only fails to induce apoptosis but also protects against TRAIL-mediated apoptosis. Conflicting reports exist about its role in activating the NF-kappa-B pathway. The dual nature of TRAILR4 in interacting with TRAIL, both as a receptor and a protective factor, highlights the complexity of its regulatory functions in cellular responses to TRAIL signaling. TRAILR4/TNFRSF10D Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived TRAILR4/TNFRSF10D protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TRAILR4/TNFRSF10D Protein, Rhesus Macaque (HEK293, Fc) is 206 a.a., with molecular weight of ~42.9 KDa.
TRAILR4/TNFRSF10D Protein , a receptor for TRAIL. Paradoxically, it not only fails to induce apoptosis but also protects against TRAIL-mediated apoptosis. Conflicting reports exist about its role in activating the NF-kappa-B pathway. The dual nature of TRAILR4 in interacting with TRAIL, both as a receptor and a protective factor, highlights the complexity of its regulatory functions in cellular responses to TRAIL signaling. TRAILR4/TNFRSF10D Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived TRAILR4/TNFRSF10D protein, expressed by HEK293 , with C-His labeled tag. The total length of TRAILR4/TNFRSF10D Protein, Rhesus Macaque (HEK293, His) is 151 a.a., with molecular weight of ~17.3 KDa.
TRAIL R2/TNFRSF10B Protein, a receptor for TNFSF10/TRAIL, initiates apoptosis by recruiting caspase-8 via FADD. It forms the death-inducing signaling complex (DISC), activating caspases and mediating apoptosis. TRAIL R2/TNFRSF10B also activates NF-kappa-B and plays a crucial role in endoplasmic reticulum stress-induced apoptosis. In its monomeric state, it interacts with TRADD and RIPK1, and stimulation enhances interactions with BIRC2 and DDX3X. Notably, it interacts with HCMV protein UL141, highlighting its multifaceted role in apoptotic and signaling pathways. TRAIL R2/TNFRSF10B Protein, Human (HEK293, His-Avi) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Human (HEK293, His-Avi) is 127 a.a., with molecular weight of 20-25 kDa.
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Human (Biotinylated, HEK293, His-Avi) is 127 a.a., with molecular weight of 20-25 kDa.
TRAIL R2/TNFRSF10B Protein, a receptor for TNFSF10/TRAIL, activates apoptosis through FADD-mediated recruitment of caspase-8, forming the death-inducing signaling complex (DISC). It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, crucial for ER stress-induced apoptosis. In its monomeric form, it interacts with TRADD and RIPK1. Upon stimulation, enhanced interactions occur with BIRC2, DDX3X, and GSK3B, leading to DDX3X and BIRC2 cleavage. TRAIL R2/TNFRSF10B Protein, Mouse (128a.a, HEK293, His) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293, with C-His labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Mouse (128a.a, HEK293, His) is 128 a.a., with molecular weight of 30-40 kDa.
The TNFRSF10C protein is a receptor for TRAIL and lacks a cytoplasmic death domain, making it unable to induce apoptosis. Instead, it protects cells by competing for ligand binding with TRAIL-R1 and R2, acting as a decoy receptor and mitigating TRAIL-mediated apoptosis. TNFRSF10C, Human (HEK 293, His) is the recombinant human-derived TNFRSF10C, expressed by HEK293 , with C-6*His labeled tag. The total length of TNFRSF10C, Human (HEK 293, His) is 196 a.a., with molecular weight of ~40.0 kDa.
TRAIL R1/TNFRSF10A protein is a receptor for TNFSF10/TRAIL, which recruits caspase-8 through FADD to initiate cell apoptosis and form a death-inducing signaling complex (DISC). It activates NF-kappa-B and interacts with TRADD and RIPK1 in the monomeric state. TRAIL R1/TNFRSF10A Protein, Human (HEK293, hFc) is the recombinant human-derived TRAIL R1/TNFRSF10A protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TRAIL R1/TNFRSF10A Protein, Human (HEK293, hFc) is 216 a.a., with molecular weight of ~47 kDa.
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human (127a.a, HEK293, His) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Human (127a.a, HEK293, His) is 127 a.a., with molecular weight of ~18.0 kDa.
TRAIL R1/TNFRSF10A protein is a receptor for TNFSF10/TRAIL, which recruits caspase-8 through FADD to initiate cell apoptosis and form a death-inducing signaling complex (DISC). It activates NF-kappa-B and interacts with TRADD and RIPK1 in the monomeric state. TRAIL R1/TNFRSF10A Protein, Human (216a.a, HEK293, His) is the recombinant human-derived TRAIL R1/TNFRSF10A protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TRAIL R1/TNFRSF10A Protein, Human (216a.a, HEK293, His) is 216 a.a., with molecular weight of 19-30 kDa.
TRAILR4/TNFRSF10D Protein, a receptor for TRAIL, lacks the ability to induce apoptosis due to a truncated death domain. Paradoxically, it not only fails to induce apoptosis but also protects against TRAIL-mediated apoptosis. Conflicting reports exist about its role in activating the NF-kappa-B pathway. The dual nature of TRAILR4/TNFRSF10D in interacting with TRAIL, both as a receptor and a protective factor, highlights the complexity of its regulatory functions in cellular responses to TRAIL signaling. TRAILR4/TNFRSF10D Protein, Human (HEK293, His-Avi) is the recombinant human-derived TRAILR4/TNFRSF10D protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of TRAILR4/TNFRSF10D Protein, Human (HEK293, His-Avi) is 156 a.a., with molecular weight of 38-45 kDa.
TRAILR4/TNFRSF10D protein is a receptor for TRAIL and lacks the ability to induce apoptosis due to the truncated death domain. Paradoxically, not only does it fail to induce apoptosis, but it also prevents TRAIL-mediated apoptosis. TRAILR4/TNFRSF10D Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TRAILR4/TNFRSF10D protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of TRAILR4/TNFRSF10D Protein, Human (Biotinylated, HEK293, His-Avi) is 156 a.a., with molecular weight of 38-50 kDa.
TNFRSF10C Protein, a receptor for TRAIL, lacks a cytoplasmic death domain, making it unable to induce apoptosis. Instead, it may protect cells by competing with TRAIL-R1 and R2 for ligand binding, acting as a decoy receptor and mitigating TRAIL-mediated apoptosis. This unique feature underscores TNFRSF10C's regulatory complexity in modulating cellular responses to TRAIL signaling, suggesting its involvement in fine-tuning the balance between survival and apoptotic pathways. TNFRSF10C Protein, Human (210a.a, HEK293, His) is the recombinant human-derived TNFRSF10C protein, expressed by HEK293, with C-His labeled tag. The total length of TNFRSF10C Protein, Human (210a.a, HEK293, His) is 210 a.a., with molecular weight of ~23.6 KDa.
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC). It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis. TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, hFc) is 125 a.a., with molecular weight of 50-75 kDa.
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC). It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis. TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His-Fc) is 125 a.a., with molecular weight of 50-55 kDa.
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC). It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis. TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, Avi-His) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, Avi-His) is 125 a.a., with molecular weight of 20-40 kDa.
TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC). It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis. TRAIL R2/TNFRSF10B Protein, Mouse (HEK 293, hFc) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Mouse (HEK 293, hFc) is 125 a.a., with molecular weight of ~50 kDa.
Fas like protein; Apoptosis inducing protein TRICK2A/2B; Apoptosis inducing receptor TRAIL R2; CD 262; CD262; CD262 antigen; Cytotoxic TRAIL receptor 2; Death domain containing receptor for TRAIL/Apo 2L; Death domain containing receptor for TRAIL/Apo2L; D
WB, ICC/IF
Human, Mouse
TNFRSF10B Antibody (YA660) is a non-conjugated and Mouse origined monoclonal antibody about 48 kDa, targeting to TNFRSF10B (7F4). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse.
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