2. Apoptosis
  3. TNF Receptor
  4. Conatumumab

Conatumumab  (Synonyms: AMG 655; TRAIL-R2 mAb; Human Anti-TNFRSF10B Recombinant Antibody)

Cat. No.: HY-P99260 Purity: 98.90%
COA

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Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. .

For research use only. We do not sell to patients.

Conatumumab Chemical Structure

Conatumumab Chemical Structure

CAS No. : 896731-82-1

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Based on 1 publication(s) in Google Scholar

Conatumumab Related Antibodies

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Description

Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. [1][2][3].

IC50 & Target

IC50: DR5 (<1 nM)[2]
In Vitro

Conatumumab (0-10 μg/mL, 4 h) activates caspase-3/7 in Colo205, H-2122, and MiaPaCa2 cells[2].
Conatumumab (0-10 μg/mL, 24 h) reduces cell viability in sensitive tumor cell lines (Colo205, H-2122, and MiaPaCa2 cells)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Conatumumab Related Antibodies

Cell Viability Assay[2]

Cell Line: Colo205, H-2122, and MiaPaCa2 cells
Concentration: 0-10 μg/mL
Incubation Time: 24 h
Result: Dose-dependently inhibited cell viability.
In Vivo

Conatumumab (0-100 μg, i.p., twice weekly) inhibits tumor growth in mice bearing Colo205, H2122, or MiaPaCa2/T2 xenograft tumors[2].
Conatumumab (2.5 μg, i.p., three times per week) enhances the antitumor activity of chemotherapeutics (CPT11, HY-16562) (80 mg/kg) in Colo 205 xenograft[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice bearing Colo205, H2122, or MiaPaCa2/T2 xenograft tumors[2]
Dosage: 0, 0.1, 0.3, 1, 3, 10, 30, 100 μg
Administration: Intraperitoneal injection (i.p.), twice weekly.
Result: Dose-dependently inhibited tumor growth.
Induced caspase-3 activation in tumors (determined by IHC).
Clinical Trial
Molecular Weight

145.65 (kDa)

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Conatumumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.90%

COA (232 KB)

Handling Instructions (2659 KB)
References
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Conatumumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Conatumumab896731-82-1AMG 655 TRAIL-R2 mAb Human Anti-TNFRSF10B Recombinant AntibodyAMG655AMG-655TNF ReceptorTumor Necrosis Factor ReceptorTNFRTumorColo 205H-2122MiaPaCa2DR5caspaseanti-cancerInhibitorinhibitorinhibit

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