896731-82-1
896731-82-1
Chemical Structure
Conatumumab
Synonym(s): AMG 655; TRAIL-R2 mAb; Human Anti-TNFRSF10B Recombinant Antibody
- CAS No.: 896731-82-1
- Formula:N/A
- Molecular Weight:(145.44 kDa)
IUPAC Name: 2-fluoro-3-methoxy-6-methylbenzaldehyde
SMILES: [Conatumumab]
Biological Activity: Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. [1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Conatumumab | 98.90% | Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. . | ||||||||||||||||||||
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References
- [1]. Herbst RS, et al. A first-in-human study of conatumumab in adult patients with advanced solid tumors. Clin Cancer Res. 2010 Dec 1;16(23):5883-91. [Content Brief]
- [2]. Kaplan-Lefko PJ, et al. Conatumumab, a fully human agonist antibody to death receptor 5, induces apoptosis via caspase activation in multiple tumor types. Cancer Biol Ther. 2010 Apr 15;9(8):618-31. [Content Brief]
