2. Recombinant Proteins
  3. Cytokines and Growth Factors Biotinylated Proteins
  4. TNF Superfamily
  5. TNF Receptor Superfamily
  6. Death Receptor 5
  7. TRAIL R2/TNFRSF10B Protein, Human (HEK293, His-Avi)

TRAIL R2/TNFRSF10B Protein, Human (HEK293, His-Avi)

Cat. No.: HY-P78530
Handling Instructions

TRAIL R2/TNFRSF10B Protein, a receptor for TNFSF10/TRAIL, initiates apoptosis by recruiting caspase-8 via FADD. It forms the death-inducing signaling complex (DISC), activating caspases and mediating apoptosis. TRAIL R2/TNFRSF10B also activates NF-kappa-B and plays a crucial role in endoplasmic reticulum stress-induced apoptosis. In its monomeric state, it interacts with TRADD and RIPK1, and stimulation enhances interactions with BIRC2 and DDX3X. Notably, it interacts with HCMV protein UL141, highlighting its multifaceted role in apoptotic and signaling pathways. TRAIL R2/TNFRSF10B Protein, Human (HEK293, His-Avi) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Human (HEK293, His-Avi) is 127 a.a., with molecular weight of 20-25 kDa.

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Description

TRAIL R2/TNFRSF10B Protein, a receptor for TNFSF10/TRAIL, initiates apoptosis by recruiting caspase-8 via FADD. It forms the death-inducing signaling complex (DISC), activating caspases and mediating apoptosis. TRAIL R2/TNFRSF10B also activates NF-kappa-B and plays a crucial role in endoplasmic reticulum stress-induced apoptosis. In its monomeric state, it interacts with TRADD and RIPK1, and stimulation enhances interactions with BIRC2 and DDX3X. Notably, it interacts with HCMV protein UL141, highlighting its multifaceted role in apoptotic and signaling pathways. TRAIL R2/TNFRSF10B Protein, Human (HEK293, His-Avi) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of TRAIL R2/TNFRSF10B Protein, Human (HEK293, His-Avi) is 127 a.a., with molecular weight of 20-25 kDa.
Background

The TRAIL R2/TNFRSF10B Protein functions as a receptor for the cytotoxic ligand TNFSF10/TRAIL. Upon ligand binding, the adapter molecule FADD recruits caspase-8 to the activated receptor, forming the death-inducing signaling complex (DISC), which triggers caspase-8 proteolytic activation and initiates the subsequent cascade of caspases, mediating apoptosis. Additionally, TRAIL R2/TNFRSF10B promotes the activation of NF-kappa-B and is essential for endoplasmic reticulum (ER) stress-induced apoptosis. In its monomeric state, it can interact with TRADD and RIPK1, and in the absence of stimulation, it interacts with BIRC2, DDX3X, and GSK3B. Stimulation of the receptor enhances interactions with BIRC2 and DDX3X, accompanied by their cleavage. Notably, TRAIL R2/TNFRSF10B can also interact with the HCMV protein UL141, preventing cell surface expression, where two TNFRSF10B monomers interact with a UL141 homodimer, and three TNFRSF10B molecules interact with TNFSF10 homotrimer. These intricate interactions underline the multifaceted role of TRAIL R2/TNFRSF10B in apoptotic and signaling pathways.
Species

Human
Source

HEK293
Tag

C-Avi;C-His
Accession

O14763 (I56-E182)
Gene ID
Molecular Construction
N-term
TRAIL-R2 (I56-E182)
Accession # O14763
His-Avi
C-term
Synonyms
CD262; DR5; DR5TRICK2B; Fas-like protein; KILLER/DR5; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRICK2; TRICK2A; TRICKB; ZTNFR9; KILLER
Molecular Weight

20-25 kDa
Purity

Greater than 95% as determined by Tris-Bis PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

TRAIL R2/TNFRSF10B Protein, Human (HEK293, His-Avi) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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