TRAIL R1/TNFRSF10A Protein, Human (HEK293, His-Avi)

TRAIL R1/TNFRSF10A Protein, a receptor for TNFSF10/TRAIL, initiates apoptosis by recruiting caspase-8 via FADD, forming the death-inducing signaling complex (DISC). It activates NF-kappa-B and interacts with TRADD and RIPK1 in its monomeric state. TRAIL R1/TNFRSF10A forms homooligomers and heterooligomers with TNFRSF10B, interacting with the TNFSF10 homotrimer. It also interacts with ARAP1 and ZDHHC3, highlighting its role in complex signaling networks. In the absence of stimulation, it interacts with BIRC2, DDX3X, and GSK3B, and stimulation enhances these interactions, accompanied by cleavage of DDX3X and BIRC2, emphasizing its multifaceted role in apoptotic and signaling pathways. TRAIL R1/TNFRSF10A Protein, Human (HEK293, His-Avi) is the recombinant human-derived TRAIL R1/TNFRSF10A protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of TRAIL R1/TNFRSF10A Protein, Human (HEK293, His-Avi) is 206 a.a., with molecular weight of 25-30 kDa.

The TRAIL R1/TNFRSF10A Protein serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. Upon activation, the adapter molecule FADD recruits caspase-8 to the receptor, forming the death-inducing signaling complex (DISC), leading to caspase-8 proteolytic activation and initiating the subsequent cascade of caspases, mediating apoptosis. Additionally, TRAIL R1/TNFRSF10A promotes the activation of NF-kappa-B. In its monomeric state, it can interact with TRADD and RIPK1. Moreover, TRAIL R1/TNFRSF10A forms homooligomers and heterooligomers with TNFRSF10B, and three TRAIL R1 molecules interact with the TNFSF10 homotrimer. The receptor also interacts with ARAP1 and ZDHHC3, further highlighting its involvement in complex signaling networks. In the absence of stimulation, TRAIL R1/TNFRSF10A interacts with BIRC2, DDX3X, and GSK3B, and this interaction is enhanced upon receptor stimulation, accompanied by cleavage of DDX3X and BIRC2. These intricate interactions emphasize the multifaceted role of TRAIL R1/TNFRSF10A in apoptotic and signaling pathways.

Human

HEK293

C-Avi;C-His

O00220 (P34-N239)

8797  [NCBI]

25-30 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.