Py-MAA-Val-Cit-PAB-MMAE
Based on 1 Customer Validation
Py-MAA-Val-Cit-PAB-MMAE is a drug-Linker conjugates for ADC, which is composed of MMAE (HY-15162) and Py-MAA-Val-Cit-PAB linked. Py-MAA-Val-Cit-PAB-MMAE can be used to synthesize Zapadcine-3a, which targeting TRAILR2. Zapadcine-3a has broad-spectrum anti-tumor activity, and can specifically kill TRAILR2-positive tumors.
For research use only. We do not sell to patients.
- Purity: 98.46%
- CAS No.: 2247398-68-9
- Formula: C72H111N13O16S
- Molecular Weight:1446.79
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
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CD262 |
Chemical Information
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CAS No. 2247398-68-9
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Appearance Solid
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Molecular Weight 1446.79
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Formula C72H111N13O16S
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Color White to off-white
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SMILES
O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CSCCC(N4CN(CN(C4)C(C=C)=O)C(C=C)=O)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (69.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6912 mL | 3.4559 mL | 6.9119 mL | 17.2796 mL |
| 5 mM | 0.1382 mL | 0.6912 mL | 1.3824 mL | 3.4559 mL | |
| 10 mM | 0.0691 mL | 0.3456 mL | 0.6912 mL | 1.7280 mL | |
| 15 mM | 0.0461 mL | 0.2304 mL | 0.4608 mL | 1.1520 mL | |
| 20 mM | 0.0346 mL | 0.1728 mL | 0.3456 mL | 0.8640 mL | |
| 25 mM | 0.0276 mL | 0.1382 mL | 0.2765 mL | 0.6912 mL | |
| 30 mM | 0.0230 mL | 0.1152 mL | 0.2304 mL | 0.5760 mL | |
| 40 mM | 0.0173 mL | 0.0864 mL | 0.1728 mL | 0.4320 mL | |
| 50 mM | 0.0138 mL | 0.0691 mL | 0.1382 mL | 0.3456 mL | |
| 60 mM | 0.0115 mL | 0.0576 mL | 0.1152 mL | 0.2880 mL |
Py-MAA-Val-Cit-PAB-MMAE Related Classifications
HY-148875 Related Classifications
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