2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. Py-MAA-Val-Cit-PAB-MMAE

Py-MAA-Val-Cit-PAB-MMAE is a drug-Linker conjugates for ADC, which is composed of MMAE (HY-15162) and Py-MAA-Val-Cit-PAB linked. Py-MAA-Val-Cit-PAB-MMAE can be used to synthesize Zapadcine-3a, which targeting TRAILR2. Zapadcine-3a has broad-spectrum anti-tumor activity, and can specifically kill TRAILR2-positive tumors.

For research use only. We do not sell to patients.

Py-MAA-Val-Cit-PAB-MMAE Chemical Structure

Py-MAA-Val-Cit-PAB-MMAE Chemical Structure

CAS No. : 2247398-68-9

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5 mg USD 510 In-stock
10 mg USD 820 In-stock
25 mg USD 1650 In-stock
50 mg USD 2650 In-stock
100 mg USD 4250 In-stock
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Based on 1 publication(s) in Google Scholar

Py-MAA-Val-Cit-PAB-MMAE Related Antibodies

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Description

Py-MAA-Val-Cit-PAB-MMAE is a drug-Linker conjugates for ADC, which is composed of MMAE (HY-15162) and Py-MAA-Val-Cit-PAB linked. Py-MAA-Val-Cit-PAB-MMAE can be used to synthesize Zapadcine-3a, which targeting TRAILR2. Zapadcine-3a has broad-spectrum anti-tumor activity, and can specifically kill TRAILR2-positive tumors[1][2][3].

IC50 & Target[1]

CD262

 

Molecular Weight

1446.79

Formula

C72H111N13O16S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CSCCC(N4CN(CN(C4)C(C=C)=O)C(C=C)=O)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (69.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6912 mL 3.4559 mL 6.9119 mL
5 mM 0.1382 mL 0.6912 mL 1.3824 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6912 mL 3.4559 mL 6.9119 mL 17.2796 mL
5 mM 0.1382 mL 0.6912 mL 1.3824 mL 3.4559 mL
10 mM 0.0691 mL 0.3456 mL 0.6912 mL 1.7280 mL
15 mM 0.0461 mL 0.2304 mL 0.4608 mL 1.1520 mL
20 mM 0.0346 mL 0.1728 mL 0.3456 mL 0.8640 mL
25 mM 0.0276 mL 0.1382 mL 0.2765 mL 0.6912 mL
30 mM 0.0230 mL 0.1152 mL 0.2304 mL 0.5760 mL
40 mM 0.0173 mL 0.0864 mL 0.1728 mL 0.4320 mL
50 mM 0.0138 mL 0.0691 mL 0.1382 mL 0.3456 mL
60 mM 0.0115 mL 0.0576 mL 0.1152 mL 0.2880 mL
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Py-MAA-Val-Cit-PAB-MMAE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Py-MAA-Val-Cit-PAB-MMAE2247398-68-9Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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