alveolar

By Targets:	Akt (1) Antibiotic (1) Apoptosis (2) Bacterial (2) Biochemical Assay Reagents (1) Btk (1) Calmodulin (2) Caspase (1) Endogenous Metabolite (2) ERK (1) Interleukin Related (1) MEK (1) NAMPT (1) NF-κB (1) Nuclear Factor of activated T Cells (NFAT) (1) Phosphodiesterase (PDE) (1) PROTACs (1) PTEN (1) RANKL/RANK (1) TNF Receptor (1) TrxR (1)
By Research Areas:	Cancer (6) Infection (2) Inflammation/Immunology (9) Metabolic Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1076A

CALP2 TFA	Calmodulin	Inflammation/Immunology
CALP2 TFA is a calmodulin (CaM) antagonist (K_d of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca ²⁺-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca ²⁺ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages .

HY-W007894

Dimethylmalonic acid	Endogenous Metabolite	Others
Dimethylmalonic acid is a short-chain dicarboxylic acid in human serum. Dimethylmalonic acid is also a volatile organic compound detected in alveolar breath .

HY-113491

3-Phosphoglyceric acid	Biochemical Assay Reagents	Inflammation/Immunology
3-Phosphoglyceric acid is a metabolic intermediate in both glycolysis and the Calvin cycle. 3-Phosphoglyceric acid is involved in alveolar macrophage epigenetic regulation.

HY-162280

PROTAC BTK Degrader-9	PROTACs RANKL/RANK Nuclear Factor of activated T Cells (NFAT) Btk	Cancer
PROTAC BTK Degrader-9 (compound 23) is a PROTAC degrader that effectively targets BTK. PROTAC BTK Degrader-9 downregulates the BTK-PLCγ2-Ca ²⁺-NFATc1 signaling pathway activated by RANKL. Thus, PROTAC BTK Degrader-9 was able to inhibit osteoclastogenesis and attenuate alveolar bone resorption in a mouse periodontitis model .

HY-P1076

CALP2	Calmodulin	Inflammation/Immunology
CALP2 is a calmodulin (CaM) antagonist ( (K_d of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca ²⁺-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca ²⁺ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages .

HY-N12740

Napyradiomycin B4	MEK ERK	Others
Napyradiomycin B4 is a Napyradiomycin derivative, which inhibits the RANKL-induced MEK-ERK signaling pathway. Napyradiomycin B4 attenuates osteoclastogenesis and prevents alveolar bone destruction in experimental periodontitis .

HY-108534

PMX464 AW 464	TrxR	Inflammation/Immunology Cancer
PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells .

HY-106739

Motapizone NAT 05-239	Phosphodiesterase (PDE)	Inflammation/Immunology
Motapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone moderately inhibits cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages. Motapizone also inhibits human platelet aggregation by increasing intracellular cAMP .

HY-N6777

Penicillic acid 1 Publications Verification	Caspase Bacterial Apoptosis Antibiotic	Infection Cancer
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 .

HY-150214

ODN MT01	Others	Cancer
ODN MT01 was designed based on human mitochondrial DNA sequences, which is an inhibitory ODN that promotes osteocyte differentiation. ODN MT01 could promote osteoblast maturation and activation in rats, reduce rat alveolar bone absorption caused by periodontitis, regulate the expression levels of osteogenesis-related factors.

HY-150214A

ODN MT 01 sodium	Others	Cancer
ODN MT01 sodium was designed based on human mitochondrial DNA sequences, which is an inhibitory ODN that promotes osteocyte differentiation. ODN MT01 sodium could promote osteoblast maturation and activation in rats, reduce rat alveolar bone absorption caused by periodontitis, regulate the expression levels of osteogenesis-related factors.

HY-P3600

FIZZ-1 (32-51) (mouse)	Apoptosis	Inflammation/Immunology
FIZZ-1 (32-51) (mouse) is a cysteine-rich secretory protein that is highly expressed by macrophages, bronchial epithelial and type II alveolar epithelial cells (AEC) in allergic airway inflammation. FIZZ1 (32-51) (mouse) also shows an antiapoptotic effect on lung fibroblasts. FIZZ-1 (32-51) (mouse) can be used in the study of allergic pneumonia .

HY-143582

ATX inhibitor 9	Others	Cancer
ATX inhibitor 9 is a potent inhibitor of ATX. ATX inhibitor 9 is a thickened heteroaryl derivatives compound. Autotaxin (ATX), also known as ENPP2, is a secreted enzyme that is highly expressed mainly in cancer cells, bronchial epithelial cells and alveolar macrophages in the lung. ATX inhibitor 9 has the potential for the research of cancer or fibrous degenerative disease (extracted from patent WO2021078227A1, compound 3) .

HY-N10610

Ethyl rosmarinate	Others	Inflammation/Immunology
Ethyl rosmarinate is a phenolic compound that can be isolated from Lycopus lucidus. Ethyl rosmarinate has antioxidative activity. Ethyl rosmarinate inhibits lung inflammation .

HY-N8884

Coelonin	PTEN Akt NF-κB Interleukin Related TNF Receptor	Inflammation/Immunology
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein .

HY-147089

PRRSV/CD163-IN-1	Bacterial Endogenous Metabolite	Infection Inflammation/Immunology
PRRSV/CD163-IN-1 is a PRRSV/CD163 inhibitor. PRRSV/CD163-IN-1 can inhibit the interaction between the PRRSV glycoprotein (GP2a or GP4) and the CD163-SRCR5 domain. PRRSV/CD163-IN-1 can be used for the research of porcine reproductive and respiratory syndrome (PRRS) .

HY-126255

SBI-797812	NAMPT	Metabolic Disease
SBI-797812 is an orally active nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 shifts NAMPT to NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD ⁺. SBI-797812 increases intracellular nicotinamide mononucleotide (NMN) and elevates liver NAD ⁺ in mice .

Cat. No.	Product Name	Target	Research Area

HY-P1076A

CALP2 TFA	Calmodulin	Inflammation/Immunology
CALP2 TFA is a calmodulin (CaM) antagonist (K_d of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca ²⁺-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca ²⁺ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages .

HY-P1076

CALP2	Calmodulin	Inflammation/Immunology
CALP2 is a calmodulin (CaM) antagonist ( (K_d of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca ²⁺-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca ²⁺ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages .

HY-P3600

FIZZ-1 (32-51) (mouse)	Apoptosis	Inflammation/Immunology
FIZZ-1 (32-51) (mouse) is a cysteine-rich secretory protein that is highly expressed by macrophages, bronchial epithelial and type II alveolar epithelial cells (AEC) in allergic airway inflammation. FIZZ1 (32-51) (mouse) also shows an antiapoptotic effect on lung fibroblasts. FIZZ-1 (32-51) (mouse) can be used in the study of allergic pneumonia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W007894

Dimethylmalonic acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Dimethylmalonic acid is a short-chain dicarboxylic acid in human serum. Dimethylmalonic acid is also a volatile organic compound detected in alveolar breath .

HY-113491

3-Phosphoglyceric acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Biochemical Assay Reagents
3-Phosphoglyceric acid is a metabolic intermediate in both glycolysis and the Calvin cycle. 3-Phosphoglyceric acid is involved in alveolar macrophage epigenetic regulation.

HY-N10610

Ethyl rosmarinate	Structural Classification Labiatae Phenols Polyphenols Plants Dolomiaea souliei (Franch.) Shih	Others
Ethyl rosmarinate is a phenolic compound that can be isolated from Lycopus lucidus. Ethyl rosmarinate has antioxidative activity. Ethyl rosmarinate inhibits lung inflammation .

HY-N12740

Napyradiomycin B4	Structural Classification Natural Products Microorganisms Source classification	MEK ERK
Napyradiomycin B4 is a Napyradiomycin derivative, which inhibits the RANKL-induced MEK-ERK signaling pathway. Napyradiomycin B4 attenuates osteoclastogenesis and prevents alveolar bone destruction in experimental periodontitis .

HY-N8884

Coelonin	Structural Classification Appendicula reflexa Blume Orchidaceae Source classification Phenols Polyphenols Plants	PTEN Akt NF-κB Interleukin Related TNF Receptor
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein .

HY-147089

PRRSV/CD163-IN-1	Infection Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Bacterial Endogenous Metabolite
PRRSV/CD163-IN-1 is a PRRSV/CD163 inhibitor. PRRSV/CD163-IN-1 can inhibit the interaction between the PRRSV glycoprotein (GP2a or GP4) and the CD163-SRCR5 domain. PRRSV/CD163-IN-1 can be used for the research of porcine reproductive and respiratory syndrome (PRRS) .

Cat. No.	Compare	Product Name	Species	Source

HY-P79178

	IL-8/CXCL8 Protein, Porcine Interleukin-8; CXCL8; IL-8; alveolar macrophage chemotactic factor I; AMCF-I; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; IL8; Interleukin 8	Porcine	E. coli
	IL-8/CXCL8 protein, a vital chemotactic factor, orchestrates inflammatory responses by attracting neutrophils, basophils, and T-cells to clear pathogens. It activates neutrophils and binds to CXCR1/CXCR2 receptors, initiating downstream signaling pathways. IL-8/CXCL8 homodimerizes, disrupted by tick evasin-3, and interacts with TNFAIP6, potentially regulating chemokine activity in the inflammatory microenvironment. IL-8/CXCL8 Protein, Porcine is the recombinant Porcine-derived IL-8/CXCL8 protein, expressed by E. coli , with tag free. The total length of IL-8/CXCL8 Protein, Porcine is 79 a.a., with molecular weight of ~12.97 kDa.


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