PRRSV/CD163-IN-1
Based on 1 Customer Validation
PRRSV/CD163-IN-1 is a PRRSV/CD163 inhibitor. PRRSV/CD163-IN-1 can inhibit the interaction between the PRRSV glycoprotein (GP2a or GP4) and the CD163-SRCR5 domain. PRRSV/CD163-IN-1 can be used for the research of porcine reproductive and respiratory syndrome (PRRS) .
For research use only. We do not sell to patients.
- Purity: 98.28%
- CAS No.: 560995-89-3
- Formula: C25H24FN5O5S2
- Molecular Weight:557.62
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
PRRSV/CD163-IN-1 (Compound B7) (5 μM) inhibits the Protein-protein interaction (PPI) between PRRSV GP4 glycoprotein and CD163-SRCR5 domain[1].
PRRSV/CD163-IN-1 (24 h) is well-tolerated by PAMs at concentrations below 25 μM, with the LC50 value of 81.7 μM[1].
PRRSV/CD163-IN-1 (0, 5, 10, 15, or 20 μM; 4 h) inhibits PRRSV infection of PAMs in a dose-dependent manner[1].
PRRSV/CD163-IN-1 (15 μM) significantly inhibits the infection caused by both type I and type II PRRSV strains[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Porcine alveolar macrophages (PAMs)
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Concentration:0, 5, 10, 15, or 20 μM
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Incubation Time:4 h
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Result:Revealed a dose-dependent inhibition of PRRSV infection of PAMs.
Chemical Information
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CAS No. 560995-89-3
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Appearance Solid
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Molecular Weight 557.62
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Formula C25H24FN5O5S2
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Color Light yellow to yellow
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SMILES
O=S(NC1=NC2=C(N=C1NC3=CC=CC(S(=O)(N4CCOCC4)=O)=C3)C=CC=C2)(C5=CC=C(C=C5C)F)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (89.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7933 mL | 8.9667 mL | 17.9334 mL | 44.8334 mL |
| 5 mM | 0.3587 mL | 1.7933 mL | 3.5867 mL | 8.9667 mL | |
| 10 mM | 0.1793 mL | 0.8967 mL | 1.7933 mL | 4.4833 mL | |
| 15 mM | 0.1196 mL | 0.5978 mL | 1.1956 mL | 2.9889 mL | |
| 20 mM | 0.0897 mL | 0.4483 mL | 0.8967 mL | 2.2417 mL | |
| 25 mM | 0.0717 mL | 0.3587 mL | 0.7173 mL | 1.7933 mL | |
| 30 mM | 0.0598 mL | 0.2989 mL | 0.5978 mL | 1.4944 mL | |
| 40 mM | 0.0448 mL | 0.2242 mL | 0.4483 mL | 1.1208 mL | |
| 50 mM | 0.0359 mL | 0.1793 mL | 0.3587 mL | 0.8967 mL | |
| 60 mM | 0.0299 mL | 0.1494 mL | 0.2989 mL | 0.7472 mL | |
| 80 mM | 0.0224 mL | 0.1121 mL | 0.2242 mL | 0.5604 mL |
PRRSV/CD163-IN-1 Related Classifications
HY-147089 Related Classifications
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