ODN MT01
ODN MT01 was designed based on human mitochondrial DNA sequences, which is an inhibitory ODN that promotes osteocyte differentiation. ODN MT01 could promote osteoblast maturation and activation in rats, reduce rat alveolar bone absorption caused by periodontitis, regulate the expression levels of osteogenesis-related factors.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1817821-77-4
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
体外実験
ODN MT01 can stimulate the proliferation of BMSCs, the differentiation of BMSCs to osteoblasts and mRNA expression of bone-associated factors including Runx2, Osterix, OPG, RANKL and collagen I in vitro[2].
ODN MT01 nanocomplexes affected the cell cycle and promoted cell proliferation of MG63 cells[3].MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1817821-77-4
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SMILES
[ODN MT01]
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配列
DNA, d(A-C-C-C-C-C-T-C-T-A-C-C-C-C-C-T-C-T-A-C-C-C-C-C-T-C-T)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Zhang Q, Qu X, Liang C, et al. Effect of oligonucleotide MT01 delivered by N-isopropylacrylamide modified polyethyleneimine for bone regeneration. Front Bioeng Biotechnol. 2023;11:1204571. [Content Brief]
[2]. Shen Y, Feng Z, Lin C, et al. An oligodeoxynucleotide that induces differentiation of bone marrow mesenchymal stem cells to osteoblasts in vitro and reduces alveolar bone loss in rats with periodontitis. Int J Mol Sci. 2012;13(3):2877-2892. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)