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Cat. No.: HY-N12740

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Napyradiomycin B4

Napyradiomycin B4 is a Napyradiomycin derivative, which inhibits the RANKL-induced MEK-ERK signaling pathway. Napyradiomycin B4 attenuates osteoclastogenesis and prevents alveolar bone destruction in experimental periodontitis.

For research use only. We do not sell to patients.

CAS No.: 111216-63-8
Formula: C₂₅H₃₁Cl₃O₆
Molecular Weight:533.87

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Napyradiomycin B4 Chemical Structure

CAS No.: 111216-63-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All MEK Isoforms :

All ERK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	10 μM Compound: napyradiomycin B4	Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTS assay Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by MTS assay	[PMID: 24328269]

In Vitro

Napyradiomycin B4 (5 μM, 4 days) inhibits RANKL-induced osteoclast differentation^[1].
Napyradiomycin B4 (5 μM, 4 days) promotes the expressions of Nrf2 related genes and inhibits the expressions of osteoclast related genes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

BMMs
Concentration:

1-5 μM
Incubation Time:

4 days
Result:

Revealed no evidence of F-actin ring.

Real Time qPCR^[1]

Cell Line:

BMMs
Concentration:

1-5 μM
Incubation Time:

4 days
Result:

Reduced mRNA expressions of Nfatc1, Acp5, Dcstamp, Ctsk, and Mmp9.
Promoted mRNA expressions of Nrf2, Nqo1 and HO1.

In Vivo

Napyradiomycin B4 (2-12 mg/kg, i.p. for 6 days) exhibits protective effect against osteoclast-mediated bone loss, prevents periodontal bone destruction by suppressing osteoclast formation in C57BL/J6 mice model, without significant toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Ligature-induced periodontitis in C57BL/J6 mice model^[1]
Dosage:

2-12 mg/kg
Administration:

i.p. for 6 days
Result:

Prevented the alveolar bone resorption and bone loss with high dose, inhibited osteoclast formation.

Chemical Information

CAS No. 111216-63-8
Molecular Weight 533.87
Formula C₂₅H₃₁Cl₃O₆
SMILES

Cl[C@](C(C1=C(O)C=C(O)C=C1C2=O)=O)(C[C@H](C(C)(O3)C)Cl)[C@]23C[C@H]4C(C)([C@H](CC[C@@]4(O)C)Cl)C
Initial Source
- Microorganisms
marine-derived Streptomyces species
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kim JA, et al., Napyradiomycin B4 Suppresses RANKL-Induced Osteoclastogenesis and Prevents Alveolar Bone Destruction in Experimental Periodontitis. ACS Pharmacol Transl Sci. 2024 Apr 3;7(4):1023-1031. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Napyradiomycin B4

All MEK Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Napyradiomycin B4 Related Classifications

HY-N12740 Related Classifications