2. MAPK/ERK Pathway Stem Cell/Wnt
  3. MEK ERK
  4. Napyradiomycin B4

Napyradiomycin B4 is a Napyradiomycin derivative, which inhibits the RANKL-induced MEK-ERK signaling pathway. Napyradiomycin B4 attenuates osteoclastogenesis and prevents alveolar bone destruction in experimental periodontitis.

For research use only. We do not sell to patients.

Napyradiomycin B4 Chemical Structure

Napyradiomycin B4 Chemical Structure

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Napyradiomycin B4 Related Antibodies

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Description

Napyradiomycin B4 is a Napyradiomycin derivative, which inhibits the RANKL-induced MEK-ERK signaling pathway. Napyradiomycin B4 attenuates osteoclastogenesis and prevents alveolar bone destruction in experimental periodontitis[1].

In Vitro

Napyradiomycin B4 (5 μM, 4 days) inhibits RANKL-induced osteoclast differentation[1].
Napyradiomycin B4 (5 μM, 4 days) promotes the expressions of Nrf2 related genes and inhibits the expressions of osteoclast related genes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Napyradiomycin B4 Related Antibodies

Immunofluorescence[1]

Cell Line: BMMs
Concentration: 1-5 μM
Incubation Time: 4 days
Result: Revealed no evidence of F-actin ring.

Real Time qPCR[1]

Cell Line: BMMs
Concentration: 1-5 μM
Incubation Time: 4 days
Result: Reduced mRNA expressions of Nfatc1, Acp5, Dcstamp, Ctsk, and Mmp9.
Promoted mRNA expressions of Nrf2, Nqo1 and HO1.
In Vivo

Napyradiomycin B4 (2-12 mg/kg, i.p. for 6 days) exhibits protective effect against osteoclast-mediated bone loss, prevents periodontal bone destruction by suppressing osteoclast formation in C57BL/J6 mice model, without significant toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ligature-induced periodontitis in C57BL/J6 mice model[1]
Dosage: 2-12 mg/kg
Administration: i.p. for 6 days
Result: Prevented the alveolar bone resorption and bone loss with high dose, inhibited osteoclast formation.
Molecular Weight

533.87

Formula

C25H31Cl3O6
SMILES

Cl[C@](C(C1=C(O)C=C(O)C=C1C2=O)=O)(C[C@H](C(C)(O3)C)Cl)[C@]23C[C@H]4C(C)([C@H](CC[C@@]4(O)C)Cl)C
Structure Classification
Initial Source

marine-derived Streptomyces species
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Napyradiomycin B4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Napyradiomycin B4Napyradiomycin B 4Napyradiomycin B-4MEKERKMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesperiodontitisC57BL/J6 miceBMMYP127Streptomycesbone diseaseInhibitorinhibitorinhibit

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