Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis

  • J Nat Prod. 2014 Jan 24;77(1):15-21. doi: 10.1021/np400466j.
Lauge Farnaes  1 ,  Nicole G Coufal ,  Christopher A Kauffman ,  Arnold L Rheingold ,  Antonio G DiPasquale ,  Paul R Jensen ,  William Fenical
Affiliations
  • 1. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego , La Jolla, California 92093-0204, United States.
PMID: 24328269 DOI: 10.1021/np400466j
Abstract

The microbial production, isolation, and structure elucidation of four new napyradiomycin congeners (1-4) is reported. The structures of these compounds, which are new additions to the marine-derived meroterpenoids, were defined by comprehensive spectroscopic analysis and by X-ray crystallography. Using fluorescence-activated cell sorting (FACS) analysis, napyradiomycins 1-4 were observed to induce Apoptosis in the colon adenocarcinoma cell line HCT-116, indicating the possibility of a specific biochemical target for this class of cytotoxins.