2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Motapizone

Motapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone moderately inhibits cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages. Motapizone also inhibits human platelet aggregation by increasing intracellular cAMP.

For research use only. We do not sell to patients.

Motapizone Chemical Structure

Motapizone Chemical Structure

CAS No. : 90697-57-7

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Based on 1 publication(s) in Google Scholar

Motapizone Related Antibodies

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Description

Motapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone moderately inhibits cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages. Motapizone also inhibits human platelet aggregation by increasing intracellular cAMP[1][2].

IC50 & Target[1]

PDE3

 

In Vitro

Motapizone (10 μM; 15 min before oxidants) results 20% inhibition rate for cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages with oxidative stress conditions, but the inhibitory effect is not affected by oxidative stress[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Motapizone Related Antibodies
Molecular Weight

260.31

Formula

C12H12N4OS
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(C1)C(C2=CC(N3C=CN=C3)=CS2)=NNC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Motapizone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Motapizone90697-57-7NAT 05-239Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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