90697-57-7
90697-57-7
Chemical Structure
Motapizone
Synonym(s): NAT 05-239
- CAS No.: 90697-57-7
- Formula:C12H12N4OS
- Molecular Weight:260.31
IUPAC Name: 6-(4-(1H-imidazol-1-yl)thiophen-2-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
InChIKey: NPFVRBCDMFKOPY-UHFFFAOYSA-N
SMILES: CC(C1)C(C2=CC(N3C=CN=C3)=CS2)=NNC1=O
Biological Activity: Motapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone moderately inhibits cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages. Motapizone also inhibits human platelet aggregation by increasing intracellular cAMP[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Motapizone | 95.0% | Motapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone moderately inhibits cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages. Motapizone also inhibits human platelet aggregation by increasing intracellular cAMP. | ||||||||||||||||||||
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References
- [1]. Milara J, et al. Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages. Clin Exp Allergy. 2011 Apr;41(4):535-46. [Content Brief]
- [2]. Borbe HO, et al. Inhibition of human platelet aggregation by motapizone via an increase in intracellular cAMP. Agents Actions Suppl. 1986;20:249-57. [Content Brief]
Keywords
