Coelonin 

Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein^[1][2].

Coelonin (2.5 μg/mL) significantly reduces both NF-κB p65 and p105/50 phosphorylation levels^[1].
Coelonin (0-5 μg/mL, 1.5 h) dose dependently reduces the increase of the phosphorylation of PTEN, AKT and IκBa induced by LPS^[1].
Coelonin (10 and 20 μg/ml) mitigates particulate matter 2.5 (PM2.5)-induced inflammation by reducing the generation of inflammatory factors, including interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α)^[2].
The inhibition of IL-1β, IL-6 and TNF-α expression by Coelonin is independent of PTEN, whereas the inhibition of p27^Kip1 degradation results in cell-cycle arrest in the G1 phase, which is dependent on PTEN^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

242.27

C₁₅H₁₄O₃

82344-82-9

OC(C=C1CC2)=CC(OC)=C1C3=C2C=C(O)C=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jiang F, et al. Coelonin, an Anti-Inflammation Active Component of Bletilla striata and Its Potential Mechanism. Int J Mol Sci. 2019 Sep 8;20(18):4422.  [Content Brief]

  [2]. Cheng W, et al. Inhibition of inflammation-induced injury and cell migration by coelonin and militarine in PM2.5-exposed human lung alveolar epithelial A549 cells. Eur J Pharmacol. 2021 Apr 5;896:173931.  [Content Brief]