82344-82-9
82344-82-9
Chemical Structure
Coelonin
- CAS No.: 82344-82-9
- Formula:C15H14O3
- Molecular Weight:242.27
IUPAC Name: 4-methoxy-9,10-dihydrophenanthrene-2,7-diol
InChIKey: OPPGAHUCKDKQJR-UHFFFAOYSA-N
SMILES: OC(C=C1CC2)=CC(OC)=C1C3=C2C=C(O)C=C3
Biological Activity: Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein[1][2].
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Coelonin | 98.0% | Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein. | ||||||||||||||||||||
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References
- [1]. Jiang F, et al. Coelonin, an Anti-Inflammation Active Component of Bletilla striata and Its Potential Mechanism. Int J Mol Sci. 2019 Sep 8;20(18):4422. [Content Brief]
- [2]. Cheng W, et al. Inhibition of inflammation-induced injury and cell migration by coelonin and militarine in PM2.5-exposed human lung alveolar epithelial A549 cells. Eur J Pharmacol. 2021 Apr 5;896:173931. [Content Brief]
