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Results for "

carboxylesterases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin-converting Enzyme (ACE) (2) Antibiotic (1) Apoptosis (2) Autophagy (2) Bacterial (1) Cholinesterase (ChE) (1) DNA/RNA Synthesis (1) Fluorescent Dye (3) HDAC (1) Opioid Receptor (2) Reactive Oxygen Species (1) Wnt (2)
By Research Areas:	Cancer (10) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (2) Metabolic Disease (7) Neurological Disease (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-142688

Carboxylesterase-IN-2	Wnt	Cancer
Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC₅₀ less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease .

HY-142689

Carboxylesterase-IN-3	Wnt	Cancer
Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC₅₀ less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease .

HY-144809

*Pancreatic lipase/Carboxylesterase* 1-IN-1**	Others	Metabolic Disease
Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) is a potent dual inhibitor of pancreatic lipase (PL) and *human carboxylesterase* 1A (hCES1A) with IC₅₀** values of 2.13 µM and 0.055 µM against PL and hCES1A .

HY-N3413

Kushenol X	Others	Metabolic Disease
Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and *human carboxylesterase* 2 (hCE2) inhibitor with IC₅₀**s of 2.07 μM and 3.05 μM, respectively .

HY-N10686

Tanshinone IIA anhydride	Cholinesterase (ChE)	Cancer
Tanshinone IIA anhydride is a potent and irreversible human carboxylesterase (CE) inhibitor with K_i values of 1.9 nM and 1.4 nM for human CE1 and the human intestinal CE (hiCE), respectively .

HY-W354821

4-Methylumbelliferyl Decanoate 4-MUD	Fluorescent Dye	Metabolic Disease
4-Methyl-2-oxo-2H-1-benzopyran-7-yl decanoate is a fluorogenic substrate used to follow the hydrolytic activity of carboxylesterases .

HY-147331

Oseltamivir acid methyl ester	Antibiotic	Neurological Disease
Oseltamivir acid methyl ester is a precursor form of the neuraminidase inhibitor and antiviral oseltamivir acid. Oseltamivir acid methyl ester is converted to oseltamivir acid by carboxylesterase 1 (CES1) .

HY-N3921

Gancaonin I	Others	Cancer
Gancaonin I, an Isoflavone, exhibits moderate inhibition on *human carboxylesterase* 2 (hCES2A**) with IC₅₀ of 1.72 μM. Gancaonin I inhibits hCES2A-mediated fluorescein diacetate (FD) hydrolysis .

HY-147915

Benz-AP	Reactive Oxygen Species	Cancer
Benz-AP is a potent photosensitizer. Benz-AP produces singlet oxygen, with a negative correlation with hCES2 (Human carboxylesterase 2) activity. Benz-AP displays a higher photocytotoxicity potency in cancer cells under low hCES2 environments. Upon TPE (Two-photon excitation), Benz-AP produces ROS and kills cancer cells and tumor spheroids .

HY-141834

Carboxylesterase-IN-1	Others	Others
Carboxylesterase-IN-1, a novel pesticide, exhibits inhibitory action on carboxylesterase at 50 μg/mL similar to the known inhibitor triphenyl phosphate.

HY-106409

Tefinostat 1 Publications Verification CHR-2845	HDAC Apoptosis	Cancer
Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias .

HY-N3474

Isolicoflavonol	Others	Others
Isolicoflavonol potently inhibits *hCES2A (Human carboxylesterase* 2)**-mediated fluorescein diacetate hydrolysis in a reversible and mixed inhibition manner, with Ki values less than 1.0 μM .

HY-120602

WWL229	Others	Metabolic Disease
WWL229 is a selective inhibitor of carboxylesterase 3 (Ces3) with an IC₅₀ of 1.94 µM. WWL229 promotes lipid storage in cultured adipocytes and prevents basal lipolysis .

HY-B0418A

Loperamide hydrochloride 3 Publications Verification R-18553 hydrochloride	Opioid Receptor Autophagy	Neurological Disease Metabolic Disease Cancer
Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist . Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect .

HY-N1377

Nevadensin	Bacterial	Infection Metabolic Disease Inflammation/Immunology
Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC₅₀ of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive .

HY-B0418AR

Loperamide hydrochloride (Standard) R-18553 hydrochloride (Standard)	Opioid Receptor Autophagy	Neurological Disease Metabolic Disease Cancer
Loperamide (hydrochloride) (Standard) is the analytical standard of Loperamide (hydrochloride). This product is intended for research and analytical applications. Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist . Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect .

HY-155228

LK-44	Others	Inflammation/Immunology
hCES2A-IN-2 (Compound 44) is an orally active human carboxylesterase 2 (hCES2A) inhibitor (IC₅₀: 5.02 μM). hCES2A-IN-2 improves Irinotecan (HY-16562)-induced delayed diarrhea .

HY-114879

DDAO 1 Publications Verification	Fluorescent Dye	Cancer
DDAO is a promising near-infrared (NIR) red fluorescent probewith tunable excitation wavelength (600-650nm) and longemission wavelength(λem=656nm). DDAO can de desiged for detection of the activities of different enzymes such asβ-galactosidase,sulfatase, proteinphosphatase2A,carboxylesterase 2, humanalbumin andesterases .

HY-D1739

DDAO phosphate diammonium	Fluorescent Dye	Others
DDAO phosphate diammonium is a fluorescent phosphatase substrate. DDAO phosphate diammonium has tunable excitation wavelength (600-650nm) and long emission wavelength (λem=656nm). DDAO phosphate diammonium can be used to detect the activity of different enzymes such as β-galactosidase, sulfatase, protein phosphatase 2A, carboxylesterase 2, human albumin and esterase.

HY-23148

1-Methylisatin N-Methylisatin	Others	Others
1-Methylisatin is a potent and selective CE (carboxylesterases) inhibitor, with K_is of 38.2 and 5.38 μM for hiCE and hCE1, respectively. 1-Methylisatin interacts with Hb (human adult hemoglobin) by hydrophobic binding and electrostatic attraction. 1-Methylisatin can be used in the study of regulation of agent metabolism in vivo .

HY-155070

SRE-II	DNA/RNA Synthesis Apoptosis	Cancer
SRE-II, an amide derivative, is an activatable photosensitizer for photodynamic cancer research with decreased fluorescence and photosensitizing capabilities. SRE-II can be further converted into the active photosensitizer SDU Red via carboxylesterase-catalyzed amide bond cleavage. SRE-II induces DNA damage and cell apoptosis in the presence of light. SRE-II can act as a promising theranostic agent for triple-negative breast cancer .

HY-B0384

Temocapril hydrochloride	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Temocapril hydrochloride is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril hydrochloride can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases .

HY-100713

Temocapril	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Temocapril is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases .

DDAO 1 Publications Verification	Fluorescent Dyes/Probes
DDAO is a promising near-infrared (NIR) red fluorescent probewith tunable excitation wavelength (600-650nm) and longemission wavelength(λem=656nm). DDAO can de desiged for detection of the activities of different enzymes such asβ-galactosidase,sulfatase, proteinphosphatase2A,carboxylesterase 2, humanalbumin andesterases .

4-Methylumbelliferyl Decanoate 4-MUD	Chromogenic Substrates Fluorescent Dyes/Probes
4-Methyl-2-oxo-2H-1-benzopyran-7-yl decanoate is a fluorogenic substrate used to follow the hydrolytic activity of carboxylesterases .

DDAO phosphate diammonium	Fluorescent Dyes/Probes
DDAO phosphate diammonium is a fluorescent phosphatase substrate. DDAO phosphate diammonium has tunable excitation wavelength (600-650nm) and long emission wavelength (λem=656nm). DDAO phosphate diammonium can be used to detect the activity of different enzymes such as β-galactosidase, sulfatase, protein phosphatase 2A, carboxylesterase 2, human albumin and esterase.

Kushenol X	Flavanonols Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Metabolic Disease Plants Sophora flavescens Aiton Disease Research Fields	Others
Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and *human carboxylesterase* 2 (hCE2) inhibitor with IC₅₀**s of 2.07 μM and 3.05 μM, respectively .

Isolicoflavonol	Flavonols Structural Classification Flavonoids other families Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Others
Isolicoflavonol potently inhibits *hCES2A (Human carboxylesterase* 2)**-mediated fluorescein diacetate hydrolysis in a reversible and mixed inhibition manner, with Ki values less than 1.0 μM .

Nevadensin	Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Inflammation/Immunology	Bacterial
Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC₅₀ of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive .

Tanshinone IIA anhydride	Structural Classification Flavonoids Labiatae Source classification Samanea saman (Jacq.) Merr. Plants Other Flavonoids	Cholinesterase (ChE)
Tanshinone IIA anhydride is a potent and irreversible human carboxylesterase (CE) inhibitor with K_i values of 1.9 nM and 1.4 nM for human CE1 and the human intestinal CE (hiCE), respectively .

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carboxylesterases

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