Carboxylesterase-IN-3

Cat. No.: HY-142689 Purity: 98.01%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC₅₀ less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease.

For research use only. We do not sell to patients.

Carboxylesterase-IN-3 Chemical Structure

CAS No. : 2764748-92-5

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 330	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 330	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2250	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

313.16

Formula

C₁₁H₆Cl₂N₄OS

CAS No.

2764748-92-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1NN=C2C=CC(SC3=CC=C(Cl)C(Cl)=C3)=NN21

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (319.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1933 mL	15.9663 mL	31.9326 mL
5 mM	0.6387 mL	3.1933 mL	6.3865 mL
10 mM	0.3193 mL	1.5966 mL	3.1933 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.01%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (248 KB) HNMR (262 KB) LCMS (92 KB)

Handling Instructions (2659 KB)

References

[1]. Steadman D, et al. Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J Med Chem. 2022;65(1):562-578. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1933 mL	15.9663 mL	31.9326 mL	79.8314 mL
	5 mM	0.6387 mL	3.1933 mL	6.3865 mL	15.9663 mL
	10 mM	0.3193 mL	1.5966 mL	3.1933 mL	7.9831 mL
	15 mM	0.2129 mL	1.0644 mL	2.1288 mL	5.3221 mL
	20 mM	0.1597 mL	0.7983 mL	1.5966 mL	3.9916 mL
	25 mM	0.1277 mL	0.6387 mL	1.2773 mL	3.1933 mL
	30 mM	0.1064 mL	0.5322 mL	1.0644 mL	2.6610 mL
	40 mM	0.0798 mL	0.3992 mL	0.7983 mL	1.9958 mL
	50 mM	0.0639 mL	0.3193 mL	0.6387 mL	1.5966 mL
	60 mM	0.0532 mL	0.2661 mL	0.5322 mL	1.3305 mL
	80 mM	0.0399 mL	0.1996 mL	0.3992 mL	0.9979 mL
	100 mM	0.0319 mL	0.1597 mL	0.3193 mL	0.7983 mL