SRE-II
SRE-II, an amide derivative, is an activatable photosensitizer for photodynamic cancer research with decreased fluorescence and photosensitizing capabilities. SRE-II can be further converted into the active photosensitizer SDU Red via carboxylesterase-catalyzed amide bond cleavage. SRE-II induces DNA damage and cell apoptosis in the presence of light. SRE-II can act as a promising theranostic agent for triple-negative breast cancer.
For research use only. We do not sell to patients.
- Formula: C15H9ClINO2
- Molecular Weight:397.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All DNA/RNA Synthesis Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
1.31 μM
Compound: SRE-II
|
Anticancer activity against mouse 4T1 cells assessed as reduction in cell viability preincubated for 2 hrs followed by photoirradiation with 500 to 700nm and 12 J/cm^2 LED light for 24 hrs by CCK-8 assay
Anticancer activity against mouse 4T1 cells assessed as reduction in cell viability preincubated for 2 hrs followed by photoirradiation with 500 to 700nm and 12 J/cm^2 LED light for 24 hrs by CCK-8 assay
|
[PMID: 37119664] |
| MDA-MB-231 | IC50 |
1.59 μM
Compound: SRE-II
|
Anticancer activity against human MDA-MB-231 cells assessed as reduction in cell viability preincubated for 2 hrs followed by photoirradiation with 500 to 700nm and 12 J/cm^2 LED light for 24 hrs by CCK-8 assay
Anticancer activity against human MDA-MB-231 cells assessed as reduction in cell viability preincubated for 2 hrs followed by photoirradiation with 500 to 700nm and 12 J/cm^2 LED light for 24 hrs by CCK-8 assay
|
[PMID: 37119664] |
Chemical Information
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Molecular Weight 397.59
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Formula C15H9ClINO2
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SMILES
O=C(C=C1)C2=CC=CC3=C(NC(CCl)=O)C(I)=CC1=C32
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)