SRE-II
SRE-II, an amide derivative, is an activatable photosensitizer for photodynamic cancer research with decreased fluorescence and photosensitizing capabilities. SRE-II can be further converted into the active photosensitizer SDU Red via carboxylesterase-catalyzed amide bond cleavage. SRE-II induces DNA damage and cell apoptosis in the presence of light. SRE-II can act as a promising theranostic agent for triple-negative breast cancer.
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- Formule: C15H9ClINO2
- Masse moléculaire:397.59
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
1.31 μM
Compound: SRE-II
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Anticancer activity against mouse 4T1 cells assessed as reduction in cell viability preincubated for 2 hrs followed by photoirradiation with 500 to 700nm and 12 J/cm^2 LED light for 24 hrs by CCK-8 assay
Anticancer activity against mouse 4T1 cells assessed as reduction in cell viability preincubated for 2 hrs followed by photoirradiation with 500 to 700nm and 12 J/cm^2 LED light for 24 hrs by CCK-8 assay
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[PMID: 37119664] |
| MDA-MB-231 | IC50 |
1.59 μM
Compound: SRE-II
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Anticancer activity against human MDA-MB-231 cells assessed as reduction in cell viability preincubated for 2 hrs followed by photoirradiation with 500 to 700nm and 12 J/cm^2 LED light for 24 hrs by CCK-8 assay
Anticancer activity against human MDA-MB-231 cells assessed as reduction in cell viability preincubated for 2 hrs followed by photoirradiation with 500 to 700nm and 12 J/cm^2 LED light for 24 hrs by CCK-8 assay
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[PMID: 37119664] |
Chemical Information
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Masse moléculaire 397.59
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Formule C15H9ClINO2
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SMILES
O=C(C=C1)C2=CC=CC3=C(NC(CCl)=O)C(I)=CC1=C32
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SRE-II Related Classifications
HY-155070 Related Classifications
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