Carboxylesterase-IN-2

Cat. No.: HY-142688 Purity: 99.83%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC₅₀ less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease.

For research use only. We do not sell to patients.

Carboxylesterase-IN-2 Chemical Structure

CAS No. : 2764748-88-9

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 330	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 330	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2250	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

272.33

Formula

C₁₃H₁₂N₄OS

CAS No.

2764748-88-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1NN=C2C=CC(SC3=CC=C(C)C(C)=C3)=NN21

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (183.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6720 mL	18.3601 mL	36.7202 mL
5 mM	0.7344 mL	3.6720 mL	7.3440 mL
10 mM	0.3672 mL	1.8360 mL	3.6720 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.83%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (247 KB) HNMR (255 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Steadman D, et al. Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. J Med Chem. 2022;65(1):562-578. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.6720 mL	18.3601 mL	36.7202 mL	91.8004 mL
	5 mM	0.7344 mL	3.6720 mL	7.3440 mL	18.3601 mL
	10 mM	0.3672 mL	1.8360 mL	3.6720 mL	9.1800 mL
	15 mM	0.2448 mL	1.2240 mL	2.4480 mL	6.1200 mL
	20 mM	0.1836 mL	0.9180 mL	1.8360 mL	4.5900 mL
	25 mM	0.1469 mL	0.7344 mL	1.4688 mL	3.6720 mL
	30 mM	0.1224 mL	0.6120 mL	1.2240 mL	3.0600 mL
	40 mM	0.0918 mL	0.4590 mL	0.9180 mL	2.2950 mL
	50 mM	0.0734 mL	0.3672 mL	0.7344 mL	1.8360 mL
	60 mM	0.0612 mL	0.3060 mL	0.6120 mL	1.5300 mL
	80 mM	0.0459 mL	0.2295 mL	0.4590 mL	1.1475 mL
	100 mM	0.0367 mL	0.1836 mL	0.3672 mL	0.9180 mL