Isolicoflavonol
Based on 1 Customer Validation
Isolicoflavonol potently inhibits hCES2A (Human carboxylesterase 2)-mediated fluorescein diacetate hydrolysis in a reversible and mixed inhibition manner, with Ki values less than 1.0 μM.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 94805-83-1
- Formula: C20H18O6
- Molecular Weight:354.35
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BV-2 | IC50 |
2.88 μM
Compound: 107
|
Antiinflammatory activity in mouse BV-2 cells assessed as reduction in LPS-induced NO production pre-treated with compound for 1 hr followed by LPS-stimulation and measured for 23 hrs by Griess reagent based analysis
Antiinflammatory activity in mouse BV-2 cells assessed as reduction in LPS-induced NO production pre-treated with compound for 1 hr followed by LPS-stimulation and measured for 23 hrs by Griess reagent based analysis
|
[PMID: 37683361] |
| Hep 3B2 | IC50 |
11.51 μM
Compound: 16
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Cytotoxicity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Cytotoxicity against human Hep3B cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
|
[PMID: 36549116] |
| HepG2 | IC50 |
44.7 μM
Compound: 16
|
Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
|
[PMID: 36549116] |
Chemical Information
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CAS No. 94805-83-1
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Appearance Solid
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Molecular Weight 354.35
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Formula C20H18O6
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Color Light yellow to green yellow
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SMILES
O=C1C(O)=C(C2=CC(C/C=C(C)\C)=C(O)C=C2)OC3=C1C(O)=CC(O)=C3
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (282.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8221 mL | 14.1103 mL | 28.2207 mL | 70.5517 mL |
| 5 mM | 0.5644 mL | 2.8221 mL | 5.6441 mL | 14.1103 mL | |
| 10 mM | 0.2822 mL | 1.4110 mL | 2.8221 mL | 7.0552 mL | |
| 15 mM | 0.1881 mL | 0.9407 mL | 1.8814 mL | 4.7034 mL | |
| 20 mM | 0.1411 mL | 0.7055 mL | 1.4110 mL | 3.5276 mL | |
| 25 mM | 0.1129 mL | 0.5644 mL | 1.1288 mL | 2.8221 mL | |
| 30 mM | 0.0941 mL | 0.4703 mL | 0.9407 mL | 2.3517 mL | |
| 40 mM | 0.0706 mL | 0.3528 mL | 0.7055 mL | 1.7638 mL | |
| 50 mM | 0.0564 mL | 0.2822 mL | 0.5644 mL | 1.4110 mL | |
| 60 mM | 0.0470 mL | 0.2352 mL | 0.4703 mL | 1.1759 mL | |
| 80 mM | 0.0353 mL | 0.1764 mL | 0.3528 mL | 0.8819 mL | |
| 100 mM | 0.0282 mL | 0.1411 mL | 0.2822 mL | 0.7055 mL |
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