Search Result

Results for "

ileum contraction

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Adrenergic Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Calcium Channel (1) Cannabinoid Receptor (1) Chloride Channel (1) Cholecystokinin Receptor (1) Dopamine Receptor (1) Drug Derivative (2) Drug Isomer (1) Endogenous Metabolite (1) Histamine Receptor (1) Leukotriene Receptor (6) Lipoxygenase (1) Motilin Receptor (1) nAChR (4) Neurokinin Receptor (2) Opioid Receptor (4) SARS-CoV (1) Sigma Receptor (1)
By Research Areas:	Cardiovascular Disease (4) Endocrinology (1) Infection (1) Inflammation/Immunology (12) Metabolic Disease (2) Neurological Disease (12)

By Targets:

5-HT Receptor (2)

Adrenergic Receptor (1)

Angiotensin-converting Enzyme (ACE) (1)

Calcium Channel (1)

Cannabinoid Receptor (1)

Chloride Channel (1)

Cholecystokinin Receptor (1)

Dopamine Receptor (1)

Drug Derivative (2)

Drug Isomer (1)

Endogenous Metabolite (1)

Histamine Receptor (1)

Leukotriene Receptor (6)

Lipoxygenase (1)

Motilin Receptor (1)

nAChR (4)

Neurokinin Receptor (2)

Opioid Receptor (4)

SARS-CoV (1)

Sigma Receptor (1)

By Research Areas:

Cardiovascular Disease (4)

Endocrinology (1)

Infection (1)

Inflammation/Immunology (12)

Metabolic Disease (2)

Neurological Disease (12)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153508

ANO1-IN-4	Chloride Channel	Others
ANO1-IN-4 (Compound 10bm) is a reversible inhibitor for calcium-activated chloride channel transmembrane protein 16A (TMEM16A, also known as ANO1) with an IC₅₀ of 0.030 µM. ANO1-IN-4 exhibits good metabolic stability in rat liver microsomes. ANO1-IN-4 inhibits spontaneous contraction in mouse isolated ileum .

HY-169450

(-)-9-Hydroxycorynantheidine 9-O-Desmethyl mitragynine	Opioid Receptor	Neurological Disease
(-)-9-Hydroxycorynantheidine (9-O-Desmethyl mitragynine), the 9-demethyl analogue of Mitragynine, is a selective and partial agonist of μ-opioid receptor. (-)-9-Hydroxycorynantheidine inhibits electrically stimulated twitch contraction in guinea-pig ileum .

HY-120927A

Alvimopan metabolite hydrochloride	Opioid Receptor	Neurological Disease
Alvimopan metabolite hydrochloride is a peripherally restricted Opioid Receptor antagonist that inhibits the amplitude of electrically evoked contractions and spontaneous mechanical activity in guinea pig ileum .

HY-101946

AS-35	Leukotriene Receptor	Inflammation/Immunology
AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC₅₀ values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities.

HY-P10599

Scyliorhinin I	Neurokinin Receptor	Neurological Disease
Scyliorhinin I is a tachykinin-1 (NK-1) and tachykinin-2 (NK-2) receptor agonist with a K_i value of 0.9 nM for rat submandibular gland NK-1 receptor and 2 nM for hamster bladder NK-2 receptor. Scyliorhinin I has the ability to contract the longitudinal muscles of the guinea pig ileum .

HY-111918

A71378	Cholecystokinin Receptor	Metabolic Disease
A71378 is a selectivity CCK-A receptor agonist the IC₅₀ values of 0.4 nM, 300 nM, and 1,200 nM for the pancreatic CCK-A, cortical CCK-B, and gastrin receptor, respectively. A71378 elicits pancreatic amylase secretion (EC₅₀ = 0.16 nM) and ileal muscle contraction (EC₅₀ = 3.7 nM) .

HY-121020

Arcapillin	SARS-CoV	Infection Others Inflammation/Immunology
Arcapillin is a flavonoid that can be isolated from Artemisia capillaris Thunb. Arcapillin induces dose-dependent relaxation of ileum and pulmonary artery smooth muscle, causes slight urinary bladder smooth muscle contraction at highest tested concentrations. Arcapillin binds to the active site of SARS-CoV-2 M_pro via interactions with Gln139, His163, and His164, exhibits antiviral activity against SARS-CoV-2 and MERS-CoV. Arcapillin can be used for the research of gastrointestinal disorders, COVID-19, and Middle East respiratory syndrome (MERS) .

HY-130138A

(5S,6R)-DiHETE	Leukotriene Receptor	Inflammation/Immunology
(5S,6R)-DiHETE is an enantiomer of (5,6)-DiHETEs. (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC₅₀ of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists .

HY-113758

LY 163443	Leukotriene Receptor	Inflammation/Immunology
LY 163443 is a selective antagonist of leukotrienes D4 (LTD4) and E4 (LTE4). LY 163443 can antagonize LTD4-induced contractions of guinea pig ileum, trachea, and lung parenchyma. LY 163443 also inhibits tracheal contractions to LTE4 .

HY-130138B

(5S,6R)-DiHETEs (5S,6R)-(11E)-DiHETE	Leukotriene Receptor	Inflammation/Immunology
(5S,6R)-DiHETEs is the isomer of (5S,6R)-DiHETE (HY-130138A). (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC₅₀ of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists .

HY-U00127

Pyridazinediones-derivative-1	Drug Derivative	Neurological Disease
Pyridazinediones-derivative-1 has potential in treating neurodegenerative disorders. It shows an ED₅₀ of 2.1 μM for inhibiting glutamate-induced contractions of isolated guineapig ileum.

HY-P10006

Leumorphin, human	Opioid Receptor	Neurological Disease
Leumorphin, human is a potent kappa opioid receptor (κ opioid receptor) agonist. Leumorphin, human inhibits the contraction of the myenteric plexus-longitudinal muscle preparation of the guinea pig ileum .

HY-136947

RJR-2429	nAChR	Neurological Disease
RJR-2429 is a nAChR agonist (EC₅₀: 59 nM). RJR-2429 binds with high affinity to α4β2 receptor subtype (K_i = 1 nM). RJR-2429 induces ileum contraction .

HY-W747554

SM 32	nAChR	Neurological Disease
SM 32 is an analgesic. SM 32 produces an increase in ACh release. SM 32 amplifies electrically- and nicotine- evoked guinea-pig ileum contractions. SM32 induces antinociceptive effects through a central cholinergic mechanism .

HY-112707

AM9405	Cannabinoid Receptor 5-HT Receptor	Neurological Disease
AM9405 is a novel peripherally active cannabinoid type 1 (CB1) and serotonin type 3 receptor agonist. AM9405 inhibits twitch contraction of the ileum and the colon with IC₅₀s of 45.71 and 0.076 nM, respectively.

HY-130432

DBO-83 dihydrochloride	nAChR	Neurological Disease
DBO-83 dihydrochloride is a brain-penetrant nicotinic acetylcholine receptor (nAChR) agonist. DBO-83 dihydrochloride activates peripheral nicotinic acetylcholine receptors to evoke non-stimulated ileum contractions. DBO-83 dihydrochloride shows antinociceptive and anti-amnesic activities .

HY-106323

[Leu13]-Motilin KW-5139	Motilin Receptor	Metabolic Disease
[Leu13]-Motilin (KW-5139) is a motilin analogue. [Leu13]-Motilin stimulates gastrointestinal motility in the rabbit. [Leu13]-Motilin causes concentration-dependent contractions of the gastric antrum, duodenum, jejunum, ileum and the descending colon in vitro .

HY-W747563

11-trans Leukotriene D4 11-trans LTD4	Drug Isomer	Others
11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.

HY-100724

YM-17690	Leukotriene Receptor	Inflammation/Immunology
YM-17690 is a LTD₄ and LTE₄ agonist, with a pK_i value of 9.28 for [3H]LTD₄. It induces dose-dependent contractions in guinea pig ileum, lung parenchyma, and trachea, with EC₅₀ values of 16, 3.9, and 22 nM, respectively. YM-17690 can be used in research related to asthma and inflammation .

HY-136831

SR2640 QMPB	Leukotriene Receptor	Inflammation/Immunology
SR2640 is a highly efficient and selective LTD4/LTE4 antagonist that can specifically inhibit the smooth muscle contractions induced by LTD4 in the guinea pig ileum and trachea in a concentration-dependent manner, without affecting the contractions caused by histamine. SR2640 can concentration-dependently prevent the binding of 0.4 nM [3H] LTD4 to membrane receptors in guinea pig lung tissue, with an IC₅₀ of 23 nM. SR2640 can shift the dose-response curve for bronchoconstriction induced by intravenous LTD4 in guinea pigs to the right, and the extent of this shift is positively correlated with the dose of SR2640 administered. SR2640 can be used in asthma research .

HY-164010

SUN-1334H free base	Histamine Receptor Dopamine Receptor Adrenergic Receptor Sigma Receptor	Cardiovascular Disease Inflammation/Immunology
SUN-1334H free base is an orally active inhibitor for histamine H1 receptor, with an IC₅₀ of 20.3 nM and K_i of 9.7 nM. SUN-1334H free base inhibits histamine-induced contractions of isolated guinea-pig ileum with an IC₅₀ of 0.198 μM. SUN-1334H free base inhibits histamine-induced bronchoconstriction in guinea pigs, histamine-induced skin wheals in beagle dogs, and ovalbumin-induced rhinitis in guinea pigs .

HY-167129

DBO-83 free base	nAChR	Neurological Disease
DBO-83 free base is a brain-penetrant nicotinic acetylcholine receptor (nAChR) agonist. DBO-83 free base activates peripheral nicotinic acetylcholine receptors to evoke non-stimulated ileum contractions. DBO-83 free base shows antinociceptive and anti-amnesic activities .

HY-N11727

Boeravinone F	Drug Derivative	Inflammation/Immunology
Boeravinone F is a Rotenoid derivative. Boeravinone F can be isolated from Boerhaavia diffusa and Boerhavia repens. Boeravinone F inhibits Acetylcholine-induced contraction of isolated guinea pig ileum .

HY-182407

CV 5975	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
CV 5975 is an orally active angiotensin converting enzyme (ACE) competitive inhibitor with a rabbit lung ACE IC₅₀ of 3.1 nM and K_i values of 2.6 nM. CV 5975 inhibits ACE in plasma, aorta, kidney, and brain, intensifying inhibition with repeated administration. CV 5975 inhibits Angiotensin I (HY-P1032)-induced pressor responses and ileum contraction, and augments bradykinin-induced ileum contraction and depressor responses. CV 5975 reduces blood pressure via ACE-independent mechanisms, with sustained action across multiple hypertensive and normotensive animal models, intensified by repeated dosing or Hydrochlorothiazide (HY-B0252) co-administration. CV 5975 can be used for the research of hypertension .

HY-N9554

WIN-64821	Neurokinin Receptor Endogenous Metabolite Calcium Channel	Neurological Disease Inflammation/Immunology
WIN-64821 is a secondary metabolite produced by Aspergillus species, and acts as a Neurokinin Receptor antagonist. The K_i values of WIN-64821 for NK1, NK2 and NK3 receptors are 0.24 (human astrocytoma cells), 0.26 (rat duodenum) and 15.2 (guinea pig forebrain) μM, respectively. WIN-64821 inhibits apamin-induced contraction of rat vas deferens, blocks substance P-induced contraction of guinea pig ileum and Ca ²⁺ efflux in human astrocytoma cells. WIN-64821 is applicable to analgesic and anti-inflammatory research .

HY-182701

5-HT3 antagonist-7	5-HT Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
5-HT3 antagonist-7 (Compound 7e) is a competitive and selective 5-HT₃ receptor antagonist. 5-HT3 antagonist-7 inhibits 5-HT-induced contractions in guinea pig ileum and guinea pig thoracic aorta. 5-HT3 antagonist-7 prevents 2-methyl-5-HT-induced vomiting episodes in ferrets .

HY-182557

KC-11404	Lipoxygenase	Cardiovascular Disease Inflammation/Immunology
KC-11404 is an orally active antihistamine and 5-lipoxygenase inhibitor, with an IC₅₀ of 0.9 μM against guinea pig 5-lipoxygenase. KC-11404 inhibits histamine-induced contraction of isolated guinea pig ileum with an IC₅₀ of 0.26 μM. KC-11404 inhibits PAF-induced rabbit platelet aggregation with an IC₅₀ of 2.0 μM. It inhibits the histamine phase of antigen-induced bronchoconstriction and PAF-induced bronchoconstriction in guinea pigs. KC-11404 can be used for the research of asthma .

HY-182563

Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide	Opioid Receptor	Endocrinology
Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide is a μ/δ opioid receptor ligand with high μ opioid receptor selectivity and agonist activity. Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide has an IC₅₀ of 237 nM for μ receptors and 1050 nM for δ receptors. Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide shows K_i values of 17 nM for μ receptors and 480 nM for δ receptors. Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide inhibits electrically evoked contractions of guinea pig ileum and mouse vas deferens. Tyr-Ala-N-(1,3-dimethylbutyl)glycinamide serves as a starting compound for structure-activity relationship investigations of μ receptor recognition .

Cat. No.	Product Name	Target	Research Area