DBO-83 dihydrochloride
DBO-83 dihydrochloride is a brain-penetrant nicotinic acetylcholine receptor (nAChR) agonist. DBO-83 dihydrochloride activates peripheral nicotinic acetylcholine receptors to evoke non-stimulated ileum contractions. DBO-83 dihydrochloride shows antinociceptive and anti-amnesic activities.
For research use only. We do not sell to patients.
- CAS No.: 195211-53-1
- Formula: C10H15Cl3N4
- Molecular Weight:297.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
DBO-83 dihydrochloride (10 µM) shows high selectivity for [3H]-cytisine-labeled nicotinic receptors, inhibiting 85% of binding at 10 µM with no activity against a panel of other receptor types[1].
DBO-83 dihydrochloride constricts guinea pig isolated ileum fragments with an EC50 of 3.05 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
DBO-83 (5-20 mg/kg; s.c.) dihydrochloride induces dose-dependent antinociception in the mouse abdominal constriction test[1].
DBO-83 (10-20 mg/kg; i.p.) dihydrochloride induces dose-dependent antinociception in the rat paw-pressure test, with a maximum paw pressure threshold of 104.6 g at 20 mg/kg i.p. measured 15 minutes after administration[1].
DBO-83 (1-10 mg/kg; i.p.) dihydrochloride shows antiamnesic activity in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss albino mice in the hot-plate tests (male, 23-30 g)[1]
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Dosage:1 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg (i.p.); 5 µg per mouse; 7.5 µg per mouse (i.c.v.)
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Administration:i.p.; i.c.v.
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Result:Produced a dose-dependent increase in licking latency, peaking 15-30 minutes after injection.
Reached licking latencies of 32.3 sec at 15 minutes, 30.4 sec at 30 minutes, and 25.9 sec at 45 minutes at 10 mg/kg i.p..
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Animal Model:Amnesic mice[2]
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Dosage:1, 5, 10 mg/kg
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Administration:i.p.
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Result:Prevented amnesia induced by Scopolamine (HY-N0296), Mecamylamine (HY-B1395A) and dihydro-β-erythroidine (HY-N10497).
Chemical Information
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CAS No. 195211-53-1
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Molecular Weight 297.61
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Formula C10H15Cl3N4
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SMILES
ClC1=CC=C(N=N1)N2CC(CC3)NC3C2.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DBO-83 dihydrochloride Related Classifications
HY-130432 Related Classifications
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