2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. DBO-83 free base

DBO-83 free base is a brain-penetrant nicotinic acetylcholine receptor (nAChR) agonist. DBO-83 free base activates peripheral nicotinic acetylcholine receptors to evoke non-stimulated ileum contractions. DBO-83 free base shows antinociceptive and anti-amnesic activities.

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DBO-83 free base

DBO-83 free base Chemical Structure

CAS No. : 286946-32-5

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DBO-83 free base Related Antibodies

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Description

DBO-83 free base is a brain-penetrant nicotinic acetylcholine receptor (nAChR) agonist. DBO-83 free base activates peripheral nicotinic acetylcholine receptors to evoke non-stimulated ileum contractions. DBO-83 free base shows antinociceptive and anti-amnesic activities[1][2].

In Vitro

DBO-83 free base (10 µM) shows high selectivity for [3H]-cytisine-labeled nicotinic receptors, inhibiting 85% of binding at 10 µM with no activity against a panel of other receptor types[1].
DBO-83 free base constricts guinea pig isolated ileum fragments with an EC50 of 3.05 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DBO-83 free base Related Antibodies
In Vivo

DBO-83 (1-20 mg/kg; i.p.; 5-7.5 µg per mouse; i.c.v.) free base induces dose-dependent, centrally mediated antinociception in the mouse hot-plate tests[1].
DBO-83 (5-20 mg/kg; s.c.) free base induces dose-dependent antinociception in the mouse abdominal constriction test[1].
DBO-83 (10-20 mg/kg; i.p.) free base induces dose-dependent antinociception in the rat paw-pressure test, with a maximum paw pressure threshold of 104.6 g at 20 mg/kg i.p. measured 15 minutes after administration[1].
DBO-83 (1-10 mg/kg; i.p.) free base shows antiamnesic activity in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mice in the hot-plate tests (male, 23-30 g)[1]
Dosage: 1 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg (i.p.); 5 µg per mouse; 7.5 µg per mouse (i.c.v.)
Administration: i.p.; i.c.v.
Result: Produced a dose-dependent increase in licking latency, peaking 15-30 minutes after injection.
Reached licking latencies of 32.3 sec at 15 minutes, 30.4 sec at 30 minutes, and 25.9 sec at 45 minutes at 10 mg/kg i.p..
Animal Model: Amnesic mice[2]
Dosage: 1, 5, 10 mg/kg
Administration: i.p.
Result: Prevented amnesia induced by Scopolamine (HY-N0296), Mecamylamine (HY-B1395A) and dihydro-β-erythroidine (HY-N10497).
Molecular Weight

224.69

Formula

C10H13ClN4
CAS No.
SMILES

ClC1=CC=C(N=N1)N2CC(CC3)NC3C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DBO-83 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBO-83286946-32-5DBO83DBO 83nAChRNicotinic acetylcholine receptorsnicotinic receptorsantinociceptionmecamylaminerat paw-pressure testileum contractionspainguinea pigsmousenicotinic acetylcholine receptormouse hot-plate test
Inhibitorinhibitorinhibit

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DBO-83 free base
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