DBO-83 free base
DBO-83 free base is a brain-penetrant nicotinic acetylcholine receptor (nAChR) agonist. DBO-83 free base activates peripheral nicotinic acetylcholine receptors to evoke non-stimulated ileum contractions. DBO-83 free base shows antinociceptive and anti-amnesic activities.
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- CAS No.: 286946-32-5
- Formule: C10H13ClN4
- Masse moléculaire:224.69
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| IMR-32 | EC50 |
12.2 μM
Compound: 1a
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Cholinergic interactions was measured with FLIPR device on IMR-32 cells of human neuroblastoma clonal line, given as effective dose
Cholinergic interactions was measured with FLIPR device on IMR-32 cells of human neuroblastoma clonal line, given as effective dose
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[PMID: 9513595] |
| K177 cell line | EC50 |
24 μM
Compound: 1a
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Cholinergic interactions was measured with FLIPR device on K177l cells and given as EC50.
Cholinergic interactions was measured with FLIPR device on K177l cells and given as EC50.
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[PMID: 9513595] |
| TE-671 | EC50 |
>1 mM
Compound: 1a
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Cholinergic interactions was measured with FLIPR device on TE671 cells and given as Effective dose
Cholinergic interactions was measured with FLIPR device on TE671 cells and given as Effective dose
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[PMID: 9513595] |
In Vitro
DBO-83 free base (10 µM) shows high selectivity for [3H]-cytisine-labeled nicotinic receptors, inhibiting 85% of binding at 10 µM with no activity against a panel of other receptor types[1].
DBO-83 free base constricts guinea pig isolated ileum fragments with an EC50 of 3.05 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
DBO-83 (5-20 mg/kg; s.c.) free base induces dose-dependent antinociception in the mouse abdominal constriction test[1].
DBO-83 (10-20 mg/kg; i.p.) free base induces dose-dependent antinociception in the rat paw-pressure test, with a maximum paw pressure threshold of 104.6 g at 20 mg/kg i.p. measured 15 minutes after administration[1].
DBO-83 (1-10 mg/kg; i.p.) free base shows antiamnesic activity in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss albino mice in the hot-plate tests (male, 23-30 g)[1]
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Dosage:1 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg (i.p.); 5 µg per mouse; 7.5 µg per mouse (i.c.v.)
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Administration:i.p.; i.c.v.
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Result:Produced a dose-dependent increase in licking latency, peaking 15-30 minutes after injection.
Reached licking latencies of 32.3 sec at 15 minutes, 30.4 sec at 30 minutes, and 25.9 sec at 45 minutes at 10 mg/kg i.p..
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Animal Model:Amnesic mice[2]
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Dosage:1, 5, 10 mg/kg
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Administration:i.p.
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Result:Prevented amnesia induced by Scopolamine (HY-N0296), Mecamylamine (HY-B1395A) and dihydro-β-erythroidine (HY-N10497).
Chemical Information
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CAS No. 286946-32-5
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Masse moléculaire 224.69
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Formule C10H13ClN4
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SMILES
ClC1=CC=C(N=N1)N2CC(CC3)NC3C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DBO-83 free base Related Classifications
HY-167129 Related Classifications
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