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inflammatory+process

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (2) Antibiotic (2) Apolipoprotein (1) Bacterial (5) Caspase (1) Deubiquitinase (2) DNA/RNA Synthesis (2) Endogenous Metabolite (5) Glucocorticoid Receptor (1) HMG-CoA Reductase (HMGCR) (2) Isotope-Labeled Compounds (1) Lipoxygenase (1) mGluR (1) mRNA (1) NOD-like Receptor (NLR) (2) Phospholipase (1) PKC (1) Pyroptosis (2) Reference Standards (4) Somatostatin Receptor (1) UGT (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Infection (3) Inflammation/Immunology (16) Neurological Disease (1)
Oligonucleotides:	mRNA (1) Interleukin & Receptors (1)

Inhibitors & Agonists

Screening Libraries

Peptides

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Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3029

Phospholipase A2 1 Publications Verification PLA2	Phospholipase	Cardiovascular Disease Inflammation/Immunology
Phospholipase A2 (PLA2) is a calcium-dependent, heat-stable enzyme that catalyzes the hydrolysis of glycerophospholipids at the sn-2 position of cellular membranes, thereby releasing Arachidonic Acid (AA) (HY-109590). Phospholipase A2 is a key mediator in the biosynthesis of pro-inflammatory lipid mediators, critically involved in inflammatory processes. Phospholipase A2 can be used for cardiovascular and inflammatory diseases research .

HY-113422

Tetrahydrocorticosterone	Endogenous Metabolite Glucocorticoid Receptor	Inflammation/Immunology
Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a key role in regulating the metabolism of carbohydrates, proteins and fats .

HY-N6712

Thiolutin 4 Publications Verification Acetopyrrothin	Antibiotic Bacterial Deubiquitinase NOD-like Receptor (NLR) DNA/RNA Synthesis Pyroptosis HMG-CoA Reductase (HMGCR)	Infection Cardiovascular Disease Cancer
Thiolutin (Acetopyrrothin) is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. Thiolutin can be produced by Streptomyces. Thiolutin inhibits AMSH (IC₅₀ = 4 μM) and Rpn11 (IC₅₀ = 0.53 μM). Thiolutin is a dual inhibitor of BRCC36 and the NLRP3 inflammasome, exhibiting anti-inflammatory effects. Thiolutin effectively suppresses the interaction between BRCC36 and HMGCR, leading to the inhibition of HCC growth. Thiolutin attenuates pyroptosis and NLRP3 inflammasome activation. Thiolutin markedly alleviates renal injury and inflammatory process in IgAN. Thiolutin is an anti-angiogenic compound which can ease Doxorubicin-induced cardiotoxicity (DOXIC) ^{[1][2][3][4][5]}.

HY-N10530

Lactodifucotetraose Difucosyllactose ; 2′,3-Difucosyllactose	Endogenous Metabolite	Inflammation/Immunology
Lactodifucotetraose is a difucosylated human milk oligosaccharide. Lactodifucotetraose inhibits platelet function and the release of inflammatory factors. Lactodifucotetraose can be used for the research of Campylobacter jejuni-associated diarrhea and platelet-induced inflammatory processes .

HY-P2091

Ac-YVAD-pNA	Caspase	Inflammation/Immunology
Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes .

HY-142699

SSTR4 agonist 2	Somatostatin Receptor	Inflammation/Immunology
SSTR4 agonist 2 is a potent agonist of somatostatin receptor subtype 4 (SSTR4). SSTR4 pathway inhibits nociceptive and inflammatory processes. SSTR4 agonist 2 has the potential for the research of medical disorders related to SSTR4 (extracted from patent WO2014184275A1, compound 107) .

HY-165061

5(Z),11(Z),14(Z)-Eicosatrienoic acid Sciadonic acid	Apolipoprotein	Inflammation/Immunology
5(Z),11(Z),14(Z)-Eicosatrienoic acid (Sciadonic acid), a polyunsaturated fatty acid sourced from maritime pine seed oil, gymnospermae leaves and seeds, and freshwater gastropods, has been shown to reduce high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1 when included in their diet. In vitro studies indicate that it diminishes cholesterol efflux, and when applied topically in its methyl ester form, it alleviates inflammatory processes, likely by displacing arachidonic acid from phospholipid pools and lowering concentrations of downstream inflammatory mediators such as prostaglandin E2 and leukotrienes.

HY-130046

16-Epiestriol 16-epi-Estriol; 16β,17β-Estriol	UGT Bacterial	Infection Inflammation/Immunology
16-Epiestriol (16-epi-Estriol; 16β,17β-Estriol) is a natural stereoisomer of estriol and an anti-inflammatory agent that targets UGT. The Ki values of 16-Epiestriol against human UGT1A10 and UGT2B7 are 98.1 μM and 162 μM, respectively. As a glucuronidation substrate, 16-Epiestriol can be modified at the 3-OH, 16-OH and 17-OH sites by various UGT enzymes; in liver microsomes, the modification mainly occurs at the 16-OH and 17-OH sites, while reactions take place at all three sites in intestinal microsomes. 16-Epiestriol acts on the phase II inflammatory process by blocking edema mediated by prostaglandins and leukocyte infiltration. It lacks glycogenic activity or any effect on blood glucose levels, and serves as an important candidate molecule in the research of inflammatory diseases .

HY-B1615R

Clenbuterol (Standard) NAB-365 (Standard)	Reference Standards Adrenergic Receptor	Inflammation/Immunology
Clenbuterol (Standard) is the analytical standard of Clenbuterol. This product is intended for research and analytical applications. Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC50 of 31.9 nM . Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator .

HY-B1615

Clenbuterol NAB-365	Adrenergic Receptor	Inflammation/Immunology
Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC₅₀ of 31.9 nM . Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator .

HY-174628

Human IL1A mRNA	mRNA	Inflammation/Immunology
Human IL1A mRNA encodes the human interleukin 1 alpha (IL1A) protein, a member of the interleukin 1 cytokine family. IL1A is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis.

HY-113434A

5(R)-HETE	Endogenous Metabolite	Inflammation/Immunology
5(R)-HETE is a lipoxygenase product of arachidonic acid. 5(R)-HETE is an inducer of neutrophil migration through endothelial and epithelial barriers. 5(R)-HETE is important in mediating lung inflammatory processes .

HY-119086

L-651392	Lipoxygenase	Inflammation/Immunology
L-651392 is an orally active and specific 5-lipoxygenase inhibitor that inhibits the production of leukotrienes. L-651392 controls the inflammatory process in Escherichia coli pyelonephritis by preventing inflammatory cells from reaching the site of infection and protecting the renal tubules from inflammation-related damage during pyelonephritis .

HY-W015546R

β-N-methylamino-L-alanine hydrochloride (Standard) BMAA hydrochloride (Standard)	Bacterial Reference Standards mGluR PKC	Neurological Disease Inflammation/Immunology
Clenbuterol (Standard) is the analytical standard of Clenbuterol. This product is intended for research and analytical applications. Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC50 of 31.9 nM . Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator .

HY-N6712R

Thiolutin (Standard) Acetopyrrothin (Standard)	Reference Standards Antibiotic Bacterial Deubiquitinase NOD-like Receptor (NLR) DNA/RNA Synthesis Pyroptosis HMG-CoA Reductase (HMGCR)	Cardiovascular Disease Inflammation/Immunology Cancer
Thromycin (Standard) is the analytical standard of thromycin (Acetopyrrothin) (HY-N6712). Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. Thiolutin can be produced by Streptomyces. Thiolutin inhibits AMSH (IC₅₀ = 4 μM) and Rpn11 (IC₅₀ = 0.53 μM). Thiolutin is a dual inhibitor of BRCC36 and the NLRP3 inflammasome, exhibiting anti-inflammatory effects. Thiolutin effectively suppresses the interaction between BRCC36 and HMGCR, leading to the inhibition of HCC growth. Thiolutin attenuates pyroptosis and NLRP3 inflammasome activation. Thiolutin markedly alleviates renal injury and inflammatory process in IgAN. Thiolutin is an anti-angiogenic compound which can ease Doxorubicin (HY-15142A)-induced cardiotoxicity (DOXIC) ^{[1][2][3][4][5]}.

HY-113422S2

Tetrahydrocorticosterone-d3-1	Isotope-Labeled Compounds Endogenous Metabolite	Inflammation/Immunology
Tetrahydrocorticosterone-d₃-1 is the deuterium labeled Tetrahydrocorticosterone (HY-113422). Tetrahydrocorticosterone is a type of glucocorticoid with notable anti-inflammatory properties. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), acts by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a role in regulating the metabolism of carbohydrates, proteins, and fats .

HY-130046R

16-Epiestriol (Standard) 16-epi-Estriol (Standard); 16β,17β-Estriol (Standard)	Endogenous Metabolite Reference Standards Bacterial	Infection Inflammation/Immunology
16-Epiestriol (Standard) is the analytical standard of 16-Epiestriol (HY-130046). This product is intended for research and analytical applications. 16-Epiestriol (16-epi-Estriol; 16β,17β-Estriol) is a natural stereoisomer of estriol and an anti-inflammatory agent that targets UGT. The Ki values of 16-Epiestriol against human UGT1A10 and UGT2B7 are 98.1 μM and 162 μM, respectively. As a glucuronidation substrate, 16-Epiestriol can be modified at the 3-OH, 16-OH and 17-OH sites by various UGT enzymes; in liver microsomes, the modification mainly occurs at the 16-OH and 17-OH sites, while reactions take place at all three sites in intestinal microsomes. 16-Epiestriol acts on the phase II inflammatory process by blocking edema mediated by prostaglandins and leukocyte infiltration. It lacks glycogenic activity or any effect on blood glucose levels, and serves as an important candidate molecule in the research of inflammatory diseases .

Cat. No.	Product Name

HY-L212

Neuropeptide Library	125 compounds
Neuropeptides are small proteins produced and released by neurons through the regulation of secretory pathways, expressed in neurons and have transmitter or co-transmitter functions, and are used as nerve substrates. Neuropeptides are by far the largest and most diverse signaling molecules in the brain and have been implicated in the development of diseases and drugs. Neuropeptides are involved in inflammatory and immune diseases and have an impact on epithelial, vascular, and connective tissue cells proliferation and tissue repair. Studies have shown that neuropeptides are particularly important when the nervous system is challenged, such as stress, injury, or substance abuse. Substance P is a neuropeptide that acts as a neurotransmitter and neuromodulator in the central nervous system and is currently in clinical research and has been shown to be involved in inflammatory processes and pain. MCE can provide 125 neuropeptides that can be used for scientific research.

Neuropeptide Library

125 compounds

Neuropeptides are small proteins produced and released by neurons through the regulation of secretory pathways, expressed in neurons and have transmitter or co-transmitter functions, and are used as nerve substrates. Neuropeptides are by far the largest and most diverse signaling molecules in the brain and have been implicated in the development of diseases and drugs. Neuropeptides are involved in inflammatory and immune diseases and have an impact on epithelial, vascular, and connective tissue cells proliferation and tissue repair. Studies have shown that neuropeptides are particularly important when the nervous system is challenged, such as stress, injury, or substance abuse. Substance P is a neuropeptide that acts as a neurotransmitter and neuromodulator in the central nervous system and is currently in clinical research and has been shown to be involved in inflammatory processes and pain.

MCE can provide 125 neuropeptides that can be used for scientific research.

Cat. No.	Product Name	Target	Research Area

HY-P2091

Ac-YVAD-pNA	Caspase	Inflammation/Immunology
Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113422

Tetrahydrocorticosterone	Structural Classification Endogenous metabolite Steroids Source Classification	Endogenous Metabolite Glucocorticoid Receptor
Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a key role in regulating the metabolism of carbohydrates, proteins and fats .

HY-N6712

Thiolutin 4 Publications Verification Acetopyrrothin	Structural Classification Microorganisms Classification of Application Fields Antibiotics Metabolic Disease Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial Deubiquitinase NOD-like Receptor (NLR) DNA/RNA Synthesis Pyroptosis HMG-CoA Reductase (HMGCR)
Thiolutin (Acetopyrrothin) is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. Thiolutin can be produced by Streptomyces. Thiolutin inhibits AMSH (IC₅₀ = 4 μM) and Rpn11 (IC₅₀ = 0.53 μM). Thiolutin is a dual inhibitor of BRCC36 and the NLRP3 inflammasome, exhibiting anti-inflammatory effects. Thiolutin effectively suppresses the interaction between BRCC36 and HMGCR, leading to the inhibition of HCC growth. Thiolutin attenuates pyroptosis and NLRP3 inflammasome activation. Thiolutin markedly alleviates renal injury and inflammatory process in IgAN. Thiolutin is an anti-angiogenic compound which can ease Doxorubicin-induced cardiotoxicity (DOXIC) ^{[1][2][3][4][5]}.

HY-N10530

Lactodifucotetraose Difucosyllactose ; 2′,3-Difucosyllactose	Structural Classification Polysaccharides Animals Classification of Application Fields Other Diseases Disease Research Fields Saccharides	Endogenous Metabolite
Lactodifucotetraose is a difucosylated human milk oligosaccharide. Lactodifucotetraose inhibits platelet function and the release of inflammatory factors. Lactodifucotetraose can be used for the research of Campylobacter jejuni-associated diarrhea and platelet-induced inflammatory processes .

HY-W015546R

β-N-methylamino-L-alanine hydrochloride (Standard) BMAA hydrochloride (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Bacterial Reference Standards mGluR PKC
Clenbuterol (Standard) is the analytical standard of Clenbuterol. This product is intended for research and analytical applications. Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC50 of 31.9 nM . Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator .

HY-N6712R

Thiolutin (Standard) Acetopyrrothin (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Antibiotic Bacterial Deubiquitinase NOD-like Receptor (NLR) DNA/RNA Synthesis Pyroptosis HMG-CoA Reductase (HMGCR)
Thromycin (Standard) is the analytical standard of thromycin (Acetopyrrothin) (HY-N6712). Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. Thiolutin can be produced by Streptomyces. Thiolutin inhibits AMSH (IC₅₀ = 4 μM) and Rpn11 (IC₅₀ = 0.53 μM). Thiolutin is a dual inhibitor of BRCC36 and the NLRP3 inflammasome, exhibiting anti-inflammatory effects. Thiolutin effectively suppresses the interaction between BRCC36 and HMGCR, leading to the inhibition of HCC growth. Thiolutin attenuates pyroptosis and NLRP3 inflammasome activation. Thiolutin markedly alleviates renal injury and inflammatory process in IgAN. Thiolutin is an anti-angiogenic compound which can ease Doxorubicin (HY-15142A)-induced cardiotoxicity (DOXIC) ^{[1][2][3][4][5]}.

Cat. No.	Product Name	Chemical Structure

HY-113422S2

Tetrahydrocorticosterone-d3-1
Tetrahydrocorticosterone-d₃-1 is the deuterium labeled Tetrahydrocorticosterone (HY-113422). Tetrahydrocorticosterone is a type of glucocorticoid with notable anti-inflammatory properties. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), acts by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a role in regulating the metabolism of carbohydrates, proteins, and fats .

Tetrahydrocorticosterone-d3-1

Tetrahydrocorticosterone-d₃-1 is the deuterium labeled Tetrahydrocorticosterone (HY-113422). Tetrahydrocorticosterone is a type of glucocorticoid with notable anti-inflammatory properties. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), acts by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a role in regulating the metabolism of carbohydrates, proteins, and fats .

Cat. No.	Product Name		Classification

HY-174628

Human IL1A mRNA		mRNA Interleukin & Receptors
Human IL1A mRNA encodes the human interleukin 1 alpha (IL1A) protein, a member of the interleukin 1 cytokine family. IL1A is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis.

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inflammatory+process

Inhibitors & Agonists

Screening Libraries

Peptides

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products