Tetrahydrocorticosterone
Based on 1 Customer Validation
Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a key role in regulating the metabolism of carbohydrates, proteins and fats.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 68-42-8
- Formula: C21H34O4
- Molecular Weight:350.49
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Endogenous Metabolite Isoforms
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Biological Activity
Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to GC receptors and inhibiting inflammatory processes[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 68-42-8
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Appearance Solid
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Molecular Weight 350.49
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Formula C21H34O4
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Color White to off-white
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SMILES
C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C[C@H](O)CC2)([H])[C@@](CC[C@@H]4C(CO)=O)([H])[C@]4(C)C[C@@H]3O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (285.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. McInnes KJ, et al. (May 2004). 5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor. The Journal of Biological Chemistry. 279 (22): 22908-12. [Content Brief]
[2]. Higashi T, et al. Studies on neurosteroids XXIII. Analysis of tetrahydrocorticosterone isomers in the brain of rats exposed to immobilization using LC-MS. Steroids. 2007;72(13):865-874. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8531 mL | 14.2657 mL | 28.5315 mL | 71.3287 mL |
| 5 mM | 0.5706 mL | 2.8531 mL | 5.7063 mL | 14.2657 mL | |
| 10 mM | 0.2853 mL | 1.4266 mL | 2.8531 mL | 7.1329 mL | |
| 15 mM | 0.1902 mL | 0.9510 mL | 1.9021 mL | 4.7552 mL | |
| 20 mM | 0.1427 mL | 0.7133 mL | 1.4266 mL | 3.5664 mL | |
| 25 mM | 0.1141 mL | 0.5706 mL | 1.1413 mL | 2.8531 mL | |
| 30 mM | 0.0951 mL | 0.4755 mL | 0.9510 mL | 2.3776 mL | |
| 40 mM | 0.0713 mL | 0.3566 mL | 0.7133 mL | 1.7832 mL | |
| 50 mM | 0.0571 mL | 0.2853 mL | 0.5706 mL | 1.4266 mL | |
| 60 mM | 0.0476 mL | 0.2378 mL | 0.4755 mL | 1.1888 mL | |
| 80 mM | 0.0357 mL | 0.1783 mL | 0.3566 mL | 0.8916 mL | |
| 100 mM | 0.0285 mL | 0.1427 mL | 0.2853 mL | 0.7133 mL |
Tetrahydrocorticosterone Related Classifications
Cat. No.: HY-113422
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- Tetrahydrocorticosterone
- 68-42-8
- Endogenous Metabolite
- Glucocorticoid Receptor
- male rats
- glucocorticoid receptor
- HeLa cells
- hypothalamic-pituitary-adrenal axis
- adrenalectomized lean male Zucker rats
- H4IIE hepatoma cells
- rat liver homogenates
- rat hepatocytes
- phosphoenolpyruvate carboxykinase
- tyrosine aminotransferase
- Inhibitor
- inhibitor
- inhibit