Tetrahydrocorticosterone
Based on 1 Customer Validation
Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a key role in regulating the metabolism of carbohydrates, proteins and fats.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.90%
- CAS 番号: 68-42-8
- 分子式: C21H34O4
- 分子量:350.49
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体外実験
Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to GC receptors and inhibiting inflammatory processes[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 68-42-8
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性状 Solid
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分子量 350.49
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分子式 C21H34O4
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Color White to off-white
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SMILES
C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C[C@H](O)CC2)([H])[C@@](CC[C@@H]4C(CO)=O)([H])[C@]4(C)C[C@@H]3O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (285.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. McInnes KJ, et al. (May 2004). 5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor. The Journal of Biological Chemistry. 279 (22): 22908-12. [Content Brief]
[2]. Higashi T, et al. Studies on neurosteroids XXIII. Analysis of tetrahydrocorticosterone isomers in the brain of rats exposed to immobilization using LC-MS. Steroids. 2007;72(13):865-874. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8531 mL | 14.2657 mL | 28.5315 mL | 71.3287 mL |
| 5 mM | 0.5706 mL | 2.8531 mL | 5.7063 mL | 14.2657 mL | |
| 10 mM | 0.2853 mL | 1.4266 mL | 2.8531 mL | 7.1329 mL | |
| 15 mM | 0.1902 mL | 0.9510 mL | 1.9021 mL | 4.7552 mL | |
| 20 mM | 0.1427 mL | 0.7133 mL | 1.4266 mL | 3.5664 mL | |
| 25 mM | 0.1141 mL | 0.5706 mL | 1.1413 mL | 2.8531 mL | |
| 30 mM | 0.0951 mL | 0.4755 mL | 0.9510 mL | 2.3776 mL | |
| 40 mM | 0.0713 mL | 0.3566 mL | 0.7133 mL | 1.7832 mL | |
| 50 mM | 0.0571 mL | 0.2853 mL | 0.5706 mL | 1.4266 mL | |
| 60 mM | 0.0476 mL | 0.2378 mL | 0.4755 mL | 1.1888 mL | |
| 80 mM | 0.0357 mL | 0.1783 mL | 0.3566 mL | 0.8916 mL | |
| 100 mM | 0.0285 mL | 0.1427 mL | 0.2853 mL | 0.7133 mL |
Tetrahydrocorticosterone 関連分類
HY-113422 関連分類
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Keywords
- Tetrahydrocorticosterone
- 68-42-8
- Endogenous Metabolite
- Glucocorticoid Receptor
- male rats
- glucocorticoid receptor
- HeLa cells
- hypothalamic-pituitary-adrenal axis
- adrenalectomized lean male Zucker rats
- H4IIE hepatoma cells
- rat liver homogenates
- rat hepatocytes
- phosphoenolpyruvate carboxykinase
- tyrosine aminotransferase
- Inhibitor
- inhibitor
- inhibit