Tetrahydrocorticosterone

Cat. No.: HY-113422 Purity: 99.90%: Data Sheet
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Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a key role in regulating the metabolism of carbohydrates, proteins and fats.

For research use only. We do not sell to patients.

Tetrahydrocorticosterone Chemical Structure

CAS No. : 68-42-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Other Forms of Tetrahydrocorticosterone:

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to GC receptors and inhibiting inflammatory processes^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

350.49

Formula

C₂₁H₃₄O₄

CAS No.

68-42-8

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C[C@H](O)CC2)([H])[C@@](CC[C@@H]4C(CO)=O)([H])[C@]4(C)C[C@@H]3O

Structure Classification

Steroids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (285.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8531 mL	14.2657 mL	28.5315 mL
5 mM	0.5706 mL	2.8531 mL	5.7063 mL
10 mM	0.2853 mL	1.4266 mL	2.8531 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.90%

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Data Sheet (274 KB) SDS (251 KB)

COA (251 KB) HNMR (265 KB) RP-HPLC (213 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. McInnes KJ, et al. (May 2004). 5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor. The Journal of Biological Chemistry. 279 (22): 22908-12. [Content Brief]

[2]. Higashi T, et al. Studies on neurosteroids XXIII. Analysis of tetrahydrocorticosterone isomers in the brain of rats exposed to immobilization using LC-MS. Steroids. 2007;72(13):865-874. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8531 mL	14.2657 mL	28.5315 mL	71.3287 mL
	5 mM	0.5706 mL	2.8531 mL	5.7063 mL	14.2657 mL
	10 mM	0.2853 mL	1.4266 mL	2.8531 mL	7.1329 mL
	15 mM	0.1902 mL	0.9510 mL	1.9021 mL	4.7552 mL
	20 mM	0.1427 mL	0.7133 mL	1.4266 mL	3.5664 mL
	25 mM	0.1141 mL	0.5706 mL	1.1413 mL	2.8531 mL
	30 mM	0.0951 mL	0.4755 mL	0.9510 mL	2.3776 mL
	40 mM	0.0713 mL	0.3566 mL	0.7133 mL	1.7832 mL
	50 mM	0.0571 mL	0.2853 mL	0.5706 mL	1.4266 mL
	60 mM	0.0476 mL	0.2378 mL	0.4755 mL	1.1888 mL
	80 mM	0.0357 mL	0.1783 mL	0.3566 mL	0.8916 mL
	100 mM	0.0285 mL	0.1427 mL	0.2853 mL	0.7133 mL