Tetrahydrocorticosterone-d3
Tetrahydrocorticosterone-d3 is the d3-labeled Tetrahydrocorticosterone (HY-113422). Tetrahydrocorticosterone is a glucocorticoid. One of its active forms, 5α-Tetrahydrocorticosterone (HY-113364), exerts its effects by binding to the GC receptor and inhibiting inflammatory processes. Tetrahydrocorticosterone is naturally synthesized by the adrenal glands and plays a key role in regulating the metabolism of carbohydrates, proteins and fats.
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- 分子式: C21H31D3O4
- 分子量:353.51
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
アプリケーション
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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非標識Cas 68-42-8
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分子量 353.51
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分子式 C21H31D3O4
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SMILES
C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C[C@H](O)CC2)([H])[C@@](CC[C@]4([2H])C(C([2H])([2H])O)=O)([H])[C@]4(C)C[C@@H]3O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
純度とドキュメンテーション
参考文献
[1]. McInnes KJ, et al. (May 2004). 5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor. The Journal of Biological Chemistry. 279 (22): 22908-12. [Content Brief]
[2]. Higashi T, et al. Studies on neurosteroids XXIII. Analysis of tetrahydrocorticosterone isomers in the brain of rats exposed to immobilization using LC-MS. Steroids. 2007;72(13):865-874. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Tetrahydrocorticosterone-d3 関連分類
HY-113422S1 関連分類
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Keywords
- Tetrahydrocorticosterone-d3
- Isotope-Labeled Compounds
- Endogenous Metabolite
- Glucocorticoid Receptor
- male rats
- glucocorticoid receptor
- HeLa cells
- hypothalamic-pituitary-adrenal axis
- adrenalectomized lean male Zucker rats
- H4IIE hepatoma cells
- rat liver homogenates
- rat hepatocytes
- phosphoenolpyruvate carboxykinase
- tyrosine aminotransferase
- Inhibitor
- inhibitor
- inhibit