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Results for "

lysyl+oxidase

" in MedChemExpress (MCE) Product Catalog:

23

Inhibitors & Agonists

1

Fluorescent Dyes

1

Inhibitory Antibodies

3

Natural
Products

8

Recombinant Proteins

3

Antibodies

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Cat. No. Compare Product Name Species Source Image
  • HY-P704257
    LOX Protein, Human (C-His)

    LOX; Protein-lysine 6-oxidase; Lysyl oxidase

    		 Human E. coli
    LOX proteins play a critical role in the post-translational oxidative deamination of peptidyl lysine residues in collagen and elastin precursors, thereby shaping extracellular matrix dynamics. It regulates Ras expression, suggesting potential tumor suppressive effects, affecting cellular homeostasis and cancer-related processes. LOX Protein, Human (C-His) is the recombinant human-derived LOX protein, expressed by E. coli, with C-6*His labeled tag.
  • HY-P704258
    LOX Protein, Human (sf9, His, MBP)

    lox; LYOX; LYOX_HUMAN; Lysyl oxidase; MGC105112; Protein lysine 6 oxidase; Protein-lysine 6-oxidase

    		 Human Sf9 insect cells
    LOX proteins play a critical role in the post-translational oxidative deamination of peptidyl lysine residues in collagen and elastin precursors, thereby shaping extracellular matrix dynamics. It regulates Ras expression, suggesting potential tumor suppressive effects, affecting cellular homeostasis and cancer-related processes. LOX Protein, Human (sf9, His, MBP) is the recombinant human-derived LOX protein, expressed by Sf9 insect cells, with C-6*His and N-MBP labeled tag.
  • HY-P71606
    Lysyl oxidase homolog 4 Protein, Mouse (His)

    Loxl4; Loxc; Lysyl oxidase homolog 4; EC 1.4.3.-; Lysyl oxidase-like protein 4; Lysyl oxidase-related protein C

    		 Mouse E. coli
    LOXL4 Protein potentially modulates collagenous extracellular matrix formation, suggesting a role in regulating assembly or stability of collagen fibers. Its involvement indicates a contribution to the structural integrity of tissues. The specific mechanisms and contexts of LOXL4 in collagen matrix modulation are areas of interest, emphasizing its potential significance in tissue development and maintenance. Lysyl oxidase homolog 4 Protein, Mouse (His) is the recombinant mouse-derived Lysyl oxidase homolog 4 protein, expressed by E. coli , with N-His labeled tag.
  • HY-P74771
    LOXL2 Protein, Human (CHO, His)

    Lysyl oxidase homolog 2; Lysyl oxidase-related protein WS9-14; LOXL2

    		 Human CHO
    LOXL2 protein mediates post-translational oxidative deamination of lysine residues, leading to the formation of allysine. It specifically deaminates H3K4me3, inhibits TFIID-dependent transcription, represses E-cadherin, activates the IRE1-XBP1 pathway, and promotes cross-linking of extracellular matrix proteins. LOXL2 is involved in EMT, tumor progression, angiogenesis regulation, and chondrocyte differentiation. LOXL2 Protein, Human (CHO, His) is the recombinant human-derived LOXL2 protein, expressed by CHO , with C-His labeled tag.
  • HY-P74769
    LOXL2 Protein, Mouse (HEK293, His)

    Lysyl oxidase homolog 2; Lysyl oxidase-related protein WS9-14; LOXL2

    		 Mouse HEK293
    LOXL2 proteins play multifaceted roles in cellular processes by mediating post-translational oxidative deamination of lysine residues, leading to lysine formation. As a transcriptional corepressor, it specifically deaminates histone H3 trimethylated at "Lys-4" (H3K4me3), which is associated with transcriptional activation. LOXL2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LOXL2 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P74770
    LOXL2 Protein, Human (HEK293, His)

    Lysyl oxidase homolog 2; Lysyl oxidase-related protein WS9-14; LOXL2

    		 Human HEK293
    LOXL2 protein mediates post-translational oxidative deamination of lysine residues, leading to the formation of allysine. It specifically deaminates H3K4me3, inhibits TFIID-dependent transcription, represses E-cadherin, activates the IRE1-XBP1 pathway, and promotes cross-linking of extracellular matrix proteins. LOXL2 is involved in EMT, tumor progression, angiogenesis regulation, and chondrocyte differentiation. LOXL2 Protein, Human (HEK293, His) is the recombinant human-derived LOXL2 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P74770Y
    LOXL2 Protein, Human (HEK293, His, solution)

    Lysyl oxidase homolog 2; Lysyl oxidase-related protein WS9-14; LOXL2

    		 Human HEK293
    The LOXL2 protein functions as a mediator in the post-translational oxidative deamination of lysine residues on target proteins, leading to the formation of deaminated lysine (allysine). Acting as a transcription corepressor, LOXL2 specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Notably, LOXL2 does not exhibit activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2). Additionally, LOXL2 mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, inducing the release of TAF10 from promoters and leading to the inhibition of TFIID-dependent transcription. This repression results in the downregulation of genes essential for embryonic stem cell pluripotency, including POU5F1/OCT4, NANOG, KLF4, and SOX2. LOXL2 is involved in epithelial to mesenchymal transition (EMT), participating in the repression of E-cadherin (CDH1) through the deamination of histone H3. It interacts with the endoplasmic reticulum protein HSPA5, activating the IRE1-XBP1 pathway of the unfolded protein response, and is implicated in E-cadherin repression following hypoxia, potentially contributing to tumor progression. Furthermore, when secreted into the extracellular matrix, LOXL2 promotes the cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. It also acts as a regulator of sprouting angiogenesis and chondrocyte differentiation.
  • HY-P702915
    LOXL4 Protein, Human (His)

    LOXC; Lysyl oxidase-like 4

    		Human E. coli
    LOXL4 Protein, Human (His) is the recombinant human-derived LOXL4, expressed by E. coli , with C-6*His labeled tag. ,

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