2. Neuronal Signaling GPCR/G Protein Stem Cell/Wnt Cytoskeleton
  3. Monoamine Oxidase Guanylate Cyclase PKG Collagen
  4. LOXL2/sGC modulator-2

LOXL2/sGC modulator-2 (Compound 9k) is a selective and orally active lysyl oxidase-like 2 (LOXL2) and soluble guanylate cyclase (sGC) dual-target regulator. LOXL2/sGC modulator-2 shows inhibitory activity for LOXL2 with an IC50 of 0.1 μM and can activate sGC. LOXL2/sGC modulator-2 can ameliorate vascular remodeling and reduce pulmonary artery pressure. LOXL2/sGC modulator-2 can downregulate PKG1, PCNA, α-SMA, collagen I and fibronectin levels. LOXL2/sGC modulator-2 can be used for the research of pulmonary arterial hypertension .

For research use only. We do not sell to patients.

LOXL2/sGC modulator-2

LOXL2/sGC modulator-2 Chemical Structure

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LOXL2/sGC modulator-2 Related Antibodies

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Description

LOXL2/sGC modulator-2 (Compound 9k) is a selective and orally active lysyl oxidase-like 2 (LOXL2) and soluble guanylate cyclase (sGC) dual-target regulator. LOXL2/sGC modulator-2 shows inhibitory activity for LOXL2 with an IC50 of 0.1 μM and can activate sGC. LOXL2/sGC modulator-2 can ameliorate vascular remodeling and reduce pulmonary artery pressure. LOXL2/sGC modulator-2 can downregulate PKG1, PCNA, α-SMA, collagen I and fibronectin levels. LOXL2/sGC modulator-2 can be used for the research of pulmonary arterial hypertension [1].

Parmacokinetics
Species Dose Route Cmax C0 T1/2 AUC0-t AUC0-∞ Vd CL MRT Tmax F
Rat[1] 1 mg/kg i.v. 152.1 ng/mL 62.81 ng/mL 1.25 h 311.25 ng·h/mL 294.15 ng·h/mL 2.58 mL/kg 52.56 mL/h/kg 1.82 h / /
Rat[1] 10 mg/kg p.o. 112.05 ng/mL / 3.85 h 269.01 ng·h/mL 269.32 ng·h/mL 110.99 mL/kg 522.06 mL/h/kg 4.45 h 0.25 h 10.07 %
Molecular Weight

487.47

Formula

C25H24F3N3O4
SMILES

CCOC(CCC1=CC(NC(C2=CC=CC(OC3=CC(CN)=CC(C(F)(F)F)=N3)=C2)=O)=CC=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LOXL2/sGC modulator-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LOXL2/sGC modulator-2Monoamine OxidaseGuanylate CyclasePKGCollagenMAOcGMP-dependent protein kinaseInhibitorinhibitorinhibit

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