LOXL2/sGC modulator-2
LOXL2/sGC modulator-2 (Compound 9k) is a selective and orally active lysyl oxidase-like 2 (LOXL2) and soluble guanylate cyclase (sGC) dual-target regulator. LOXL2/sGC modulator-2 shows inhibitory activity for LOXL2 with an IC50 of 0.1 μM and can activate sGC. LOXL2/sGC modulator-2 can ameliorate vascular remodeling and reduce pulmonary artery pressure. LOXL2/sGC modulator-2 can downregulate PKG1, PCNA, α-SMA, collagen I and fibronectin levels. LOXL2/sGC modulator-2 can be used for the research of pulmonary arterial hypertension .
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C25H24F3N3O4
- 分子量:487.47
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
| Species | Dose | Route | Cmax | C0 | T1/2 | AUC0-t | AUC0-∞ | Vd | CL | MRT | Tmax | F |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rat[1] | 1 mg/kg | i.v. | 152.1 ng/mL | 62.81 ng/mL | 1.25 h | 311.25 ng·h/mL | 294.15 ng·h/mL | 2.58 mL/kg | 52.56 mL/h/kg | 1.82 h | / | / |
| Rat[1] | 10 mg/kg | p.o. | 112.05 ng/mL | / | 3.85 h | 269.01 ng·h/mL | 269.32 ng·h/mL | 110.99 mL/kg | 522.06 mL/h/kg | 4.45 h | 0.25 h | 10.07 % |
化学情報
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分子量 487.47
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分子式 C25H24F3N3O4
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SMILES
CCOC(CCC1=CC(NC(C2=CC=CC(OC3=CC(CN)=CC(C(F)(F)F)=N3)=C2)=O)=CC=C1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LOXL2/sGC modulator-2 関連分類
HY-180585 関連分類
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