LOXL2/sGC modulator-2
LOXL2/sGC modulator-2 (Compound 9k) is a selective and orally active lysyl oxidase-like 2 (LOXL2) and soluble guanylate cyclase (sGC) dual-target regulator. LOXL2/sGC modulator-2 shows inhibitory activity for LOXL2 with an IC50 of 0.1 μM and can activate sGC. LOXL2/sGC modulator-2 can ameliorate vascular remodeling and reduce pulmonary artery pressure. LOXL2/sGC modulator-2 can downregulate PKG1, PCNA, α-SMA, collagen I and fibronectin levels. LOXL2/sGC modulator-2 can be used for the research of pulmonary arterial hypertension .
For research use only. We do not sell to patients.
- Formula: C25H24F3N3O4
- Molecular Weight:487.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Parmacokinetics
| Species | Dose | Route | Cmax | C0 | T1/2 | AUC0-t | AUC0-∞ | Vd | CL | MRT | Tmax | F |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rat[1] | 1 mg/kg | i.v. | 152.1 ng/mL | 62.81 ng/mL | 1.25 h | 311.25 ng·h/mL | 294.15 ng·h/mL | 2.58 mL/kg | 52.56 mL/h/kg | 1.82 h | / | / |
| Rat[1] | 10 mg/kg | p.o. | 112.05 ng/mL | / | 3.85 h | 269.01 ng·h/mL | 269.32 ng·h/mL | 110.99 mL/kg | 522.06 mL/h/kg | 4.45 h | 0.25 h | 10.07 % |
Chemical Information
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Molecular Weight 487.47
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Formula C25H24F3N3O4
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SMILES
CCOC(CCC1=CC(NC(C2=CC=CC(OC3=CC(CN)=CC(C(F)(F)F)=N3)=C2)=O)=CC=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LOXL2/sGC modulator-2 Related Classifications
HY-180585 Related Classifications
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