oLOX 

oLOX is a fluorescent activity reporter. oLOX can be activated by lysyl oxidase family (LOXF) enzymes, which in turn releases a luciferin fluorescent product that reports LOXF enzyme activity. After oLOX is activated in in vitro fibrotic lung tissues, the fluorescence intensity increases, enabling real-time detection of fibrotic activity. oLOX can be used in studies related to pulmonary fibrosis^[1].

oLOX (10 μM; 2 h) exhibits up to a 300% increase in fluorescence in aged human lung tissue homogenate, with significant signal amplification detected after 30 min and signal plateauing between 50 min and 2 h^[1].
oLOX (200 μM) generates a significant increase in fluorescent signal in fibrotic regions of ventilating ex vivo asinine lung detectable via FCFM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

446.50

C₂₆H₂₆N₂O₅

2241794-11-4

NCCCOC1=CC2=C(C3(C4=C(O2)C=C(C=C4)OCCCN)OC(C5=C3C=CC=C5)=O)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Aslam T, et al. Optical molecular imaging of lysyl oxidase activity - detection of active fibrogenesis in human lung tissue. Chem Sci. 2015;6(8):4946-4953.