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male albino mice

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetolactate Synthase (ALS) (1) Akt (1) Antibiotic (1) Apoptosis (3) Bacterial (2) Carboxylesterase (CES) (1) Caspase (2) Cholinesterase (ChE) (2) ClpP (1) Endogenous Metabolite (2) Environmental Pollutants (1) Fungal (1) Herbicide (1) Mitochondrial Metabolism (2) Monoamine Oxidase (1) Monocarboxylate Transporter (1) nAChR (2) Opioid Receptor (1) PARP (2) Phosphatase (1) Phosphodiesterase (PDE) (1) Reference Standards (1) Survivin (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (4) Infection (3) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (3)

By Targets:

Acetolactate Synthase (ALS) (1)

Akt (1)

Antibiotic (1)

Apoptosis (3)

Bacterial (2)

Carboxylesterase (CES) (1)

Caspase (2)

Cholinesterase (ChE) (2)

ClpP (1)

Endogenous Metabolite (2)

Environmental Pollutants (1)

Fungal (1)

Herbicide (1)

Mitochondrial Metabolism (2)

Monoamine Oxidase (1)

Monocarboxylate Transporter (1)

nAChR (2)

Opioid Receptor (1)

PARP (2)

Phosphatase (1)

Phosphodiesterase (PDE) (1)

Reference Standards (1)

Survivin (1)

By Research Areas:

Cancer (4)

Cardiovascular Disease (4)

Infection (3)

Inflammation/Immunology (4)

Metabolic Disease (3)

Neurological Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1178

Cotinine 3 Publications Verification (-)-Cotinine; (S)-Cotinine; NIH-10498	Endogenous Metabolite nAChR	Cardiovascular Disease Inflammation/Immunology
Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases .

HY-P2232

Conalbumin Ovotransferrin	Bacterial	Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer
Conalbumin (Ovotransferrin) is an iron-binding protein present in egg white with antibacterial activity. Conalbumin can also be used to induce bronchial asthma. Conalbumin exhibits induced mRNA accumulation in chicken oviduct cells by estrogen and progesterone .

HY-N11908

α-Santalol cis-α-Santalol	Akt Survivin Apoptosis Caspase PARP	Metabolic Disease Cancer
α-Santalol (cis-α-Santalol), a naturally occurring sesquiterpene, is an orally active anticancer agent and apoptosis inducer. α-Santalol activates caspase-3 to drive apoptotic processes. >α-Santalol induces apoptosis, decreases cell viability, and causes PARP cleavage in human prostate cancer cells. α-santalol inhibits Akt/Survivin pathway to induce cell death. α-Santalol can be used for the research of prostate cancer and diabetes mellitus .

HY-B1847

Terbuthylazine 1 Publications Verification	Environmental Pollutants Acetolactate Synthase (ALS) Herbicide	Others
Terbuthylazine is an inhibitor of acetolactate syntase (ALS), is a selective herbicide. Terbuthylazine blocks electron transport in photosystem II via interaction with the D1-protein .

HY-75625

2-Hydroxy-4-methoxybenzoic acid 4-Methoxysalicylic Acid	Monocarboxylate Transporter Apoptosis Mitochondrial Metabolism	Cardiovascular Disease Metabolic Disease Cancer
2-Hydroxy-4-methoxybenzoic acid is an orally active inhibitor of MCT-1 and MCT-4, as well as a plant biomarker. 2-Hydroxy-4-methoxybenzoic acid can be isolated from roots. 2-Hydroxy-4-methoxybenzoic acid induces Apoptosis and loss of mitochondrial membrane potential. 2-Hydroxy-4-methoxybenzoic acid exhibits anticancer activity against breast cancer. 2-Hydroxy-4-methoxybenzoic acid normalizes lactic acid levels. 2-Hydroxy-4-methoxybenzoic acid neutralizes viper venom and attenuates its lethal, hemorrhagic, coagulant and anticoagulant activities in male albino mice. 2-Hydroxy-4-methoxybenzoic acid possesses antihyperlipidemic, antidiabetic and hepatoprotective activities .

HY-125539

Roridin E	Antibiotic Phosphatase Fungal	Infection
Roridin E is a glucose-6-phosphatase (G6Pase) inhibitor and antibiotic, and is a metabolic byproduct of Roridin A (HY-N9599). Roridin E induces significant oxidative stress, characterized by depletion of glutathione in vivo, induction of hepatic lipid peroxidation, and inhibition of renal superoxide dismutase activity. Roridin E reduces blood glucose levels in rats, but exhibits acute toxicity (which is enhanced when co-administered with linoleic acid (HY-N0729)) and causes hepatotoxicity in male albino mice. Roridin E induces a decrease in total blood protein and increases in the levels of total lipids, γ-glutamyltransferase, alkaline phosphatase, and 5'-nucleotidase. Roridin E can be isolated from molds, and possesses cytostatic and antifungal activities similar to those of Verrucarin A (HY-107426) and Roridin A. Roridin E exhibits in vivo activity in rodents and is commonly used in hepatotoxicity-related studies .

HY-101230

ICI 174864	Opioid Receptor	Neurological Disease
ICI 174864 is a selective and brain-penetrant δ-opioid receptor antagonist with K_e values of 22.0 nM to 30.6 nM at δ-opioid receptor in mouse vas deferens. ICI 174864 selectively blocks biological effects mediated by the δ-opioid receptor agonist DPDPE (HY-P1334) after central administration. ICI 174864 reverses hypotension in rats with endotoxic shock and inhibits acetic acid-induced writhing in mice. ICI 174864 can be used for the research of opioid receptor subtypes, endotoxic hypotension and analgesic pathways .

HY-178749

MS6076	ClpP Mitochondrial Metabolism Apoptosis Caspase PARP	Cancer
MS6076 is a mitochondrial protease ClpP agonist. MS6076 specifically activates the ClpP protease in the mitochondrial matrix, significantly disrupting mitochondrial Electron Transport Chain (ETC) function by accelerating the degradation of unfolded proteins. MS6076 exhibits potent cytotoxicity against a variety of cancer cell lines. MS6076 induces cell apoptosis, increasing cleavage of caspase 3 and PARP. MS6076 can be used for the research of breast cancer .

HY-162606

MAO-A/B-IN-3	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
MAO-A/B-IN-3 (Compound 12) stands out as a key dual MAO-AChE inhibitor, displaying excellent multi-target efficacy against MAO-A, MAO-B, and AChE with IC₅₀ values of 67 nM, 29 nM, and 1370 nM respectively. MAO-A/B-IN-3 is adept at altering the A site (hydrophobic ring) and C site (semicarbazone chain) within ketone amine-based MTDLs to bolster the inhibitory potential against MAO-A/B while notably diminishing activity against AChE. MAO-A/B-IN-3 is poised for research applications in the field of neurodegenerative diseases .

HY-B1178R

Cotinine (Standard) (-)-Cotinine (Standard); (S)-Cotinine (Standard); NIH-10498 (Standard)	Reference Standards Endogenous Metabolite nAChR	Cardiovascular Disease Inflammation/Immunology
Cotinine (Standard) is the analytical standard of Cotinine. This product is intended for research and analytical applications. Cotinine ((-)-Cotinine), an alkaloid in tobacco and a major metabolite of nicotine, is used as a biological indicator to measure the composition of tobacco smoke

HY-120042

Heptenophos	Carboxylesterase (CES) Cholinesterase (ChE)	Others
Heptenophos is an inhibitor of AChE and plasma carboxylesterase (CES). By inhibiting AChE activity, Heptenophos causes the accumulation of acetylcholine at cholinergic synapses, thereby triggering typical symptoms of organophosphate poisoning. Heptenophos exhibits rapid lethal toxicity in male albino mice, but its toxic effects are effectively antagonized by obidoxime, and Memantine (HY-B0591) further enhances the detoxification efficacy of obidoxime. Therefore, Heptenophos is commonly used in studies related to the mechanism of organophosphate poisoning and detoxification strategies .

HY-181770

PDE4B-IN-7	Phosphodiesterase (PDE) Bacterial	Infection Inflammation/Immunology
PDE4B-IN-7 is a PDE-4B inhibitor with an IC₅₀ of 160 nM. PDE4B-IN-7 can form a firm and stable binding with the active site of PDE-4B. PDE4B-IN-7 inhibits acetylcholine-induced bronchospasm in guinea pigs. PDE4B-IN-7 exerts activity against susceptible Gram-positive and Gram-negative bacterial strains. PDE4B-IN-7 can be used for the researches of asthma and bacterial agent .

Conalbumin Ovotransferrin	Biochemical Assay Reagents
Conalbumin (Ovotransferrin) is an iron-binding protein present in egg white with antibacterial activity. Conalbumin can also be used to induce bronchial asthma. Conalbumin exhibits induced mRNA accumulation in chicken oviduct cells by estrogen and progesterone .

Cat. No.	Product Name	Target	Research Area

HY-P3538

Corticotropin-releasing factor (Sheep) CRH (Sheep)	Peptides	Neurological Disease
Corticotropin-releasing factor (CRH) (Sheep) is a brain-penetrant hypothalamic releasing factor and a peptide hormone with analgesic and arousal-inducing activity. Corticotropin-releasing factor (Sheep) mediates stress effects, including stress-induced analgesia. Corticotropin-releasing factor (Sheep) increases wakefulness, reduces slow wave sleep, alters EEG frequency content, stimulates ACTH and β-endorphin release, activates locomotor activity. Corticotropin-releasing factor (Sheep) can be used for the research of neurological disease .