Corticotropin-releasing factor (Sheep)

Corticotropin-releasing factor (Sheep) (4-32 μg; i.v.; single dose) produces analgesia in male Wistar rats tested via the tail flick test^[1].
Corticotropin-releasing factor (Sheep) (23-118 μg/kg; i.v.; single dose) produces analgesia in male SD rats tested via the hot plate test, with an ED₅₀ of 10 nmol/kg^[1].
Corticotropin-releasing factor (Sheep) (4-14 μg; i.v.; single dose or 0.4-2.5 μg; intradermal into hindpaw; single dose) produces analgesia in anaesthetized male albino rats tested via the paw flick assay with 48°C water immersion^[1].
Corticotropin-releasing factor (Sheep) (10-40 μg/kg; i.v.; single dose or 100-200 ng; intracisternal; single dose) produces analgesia in female Std:ddy mice tested via the phenylquinone writhing assay^[1].
Corticotropin-releasing factor (Sheep) (29-86 μg/kg; i.v.; single dose) produces antinociception in anaesthetized male SD rats, with an ED₅₀ of 2.3-7 nmol/kg, as measured by reduced trigeminal neuron responses to noxious heat^[1].
Corticotropin-releasing factor (Sheep) (0.1-1.5 ng; intraplantar into inflamed hindpaw; single dose) reduces CFA-induced hyperalgesia in the inflamed hindpaw of male Wistar rats, with an ED₅₀ of 1.59 ng, via a mechanism involving immune cell-derived β-endorphin^[1].
Corticotropin-releasing factor (Sheep) (0.7 μg; i.c.v.; single dose) produces analgesia in male Wistar rats tested via the formalin test^[1].
Corticotropin-releasing factor (Sheep) (0.0015-0.015 nmol; i.c.v.; single injection) produces dose-dependent increases in arousal, marked by 91.3% and 93.8% reductions in slow wave sleep time, respectively, and corresponding shifts in cortical EEG frequency power in male Sprague-Dawley rats^[2].