MAO-A/B-IN-3
MAO-A/B-IN-3 (Compound 12) stands out as a key dual MAO-AChE inhibitor, displaying excellent multi-target efficacy against MAO-A, MAO-B, and AChE with IC50 values of 67 nM, 29 nM, and 1370 nM respectively. MAO-A/B-IN-3 is adept at altering the A site (hydrophobic ring) and C site (semicarbazone chain) within ketone amine-based MTDLs to bolster the inhibitory potential against MAO-A/B while notably diminishing activity against AChE. MAO-A/B-IN-3 is poised for research applications in the field of neurodegenerative diseases.
For research use only. We do not sell to patients.
- CAS No.: 315210-31-2
- Formula: C17H16N4O2
- Molecular Weight:308.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MAO-A 67 nM (IC50) |
MAO-B 29 nM (IC50) |
AChE 1370 nM (IC50) |
MAO-A/B-IN-3 (Compound 12) exhibites moderate permeability (16.49 nm/s) in vitro Caco2 permeability across the intestinal membrane[1]. MAO-A/B-IN-3 (Compound 12) displays moderate permeability (103.16 nm/s) to MDCK cells[1]. MAO-A/B-IN-3 (Compound 12) shows 90.97% plasma protein binding, with a binding rate more than 90% indicating strong binding, indicating its longer half-life and slow excretion profile[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 315210-31-2
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Molecular Weight 308.33
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Formula C17H16N4O2
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SMILES
O=C(N/N=C(C1=CC=C(O)C=C1)\C)CN(C=N2)C3=C2C=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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